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Biomedical subjects

S Coutrot

Publications and source records attributed to S Coutrot.

8 recordsLinked to original sources
PubMed1985

[Highlights of the dyspeptic syndrome in 1985].

Many hypotheses have been proposed to explain the development of non-lesional dyspepsia: various authors suggest an excessively delayed gastric emptying, or excessive gastric secretions or an intestinal cause. The actual pathophysiology of these disorders is probably multifactorial. In the absence of more precise data, we nevertheless have a symptomatic treatment which is often effective. The most severe dyspeptic disorders respond very well, particularly to molecules which act on the tonicity and the motility of the gastro-intestinal tract.

Dyspepsia↗
PubMed1979

Peutz-Jeghers syndrome with metastasizing carcinoma arising from a jejunal hamartoma.

The association of Peutz-Jeghers (P-J) syndrome and gastrointestinal carcinoma is well documented, but an unequivocal histologic demonstration that malignancy may originate in a hamartomatous polyp has been very rarely given. A patient with the P-J syndome is described, in whom a definite intestinal adenocarcinoma with metastases to omentum and celiac lymph nodes was shown to originate in a jejunal hamartoma. Evidence that malignancy was derived from hamartomatous structures was given by the following observations: (a) Adenocarcinoma was intimately intricated with smooth muscle bands, and well-defined transitional zone of malignant cells could be observed in several glands of the degenerated P-J polyp; and (b) close to malignant areas, glands of this polyp exhibited a less-differentiated epithelium, but were still intermixed with nonstriated muscle bundles, which strongly suggest dedifferentiation of hamartomatous structures.

Adenocarcinoma↗
PubMed1977

[Encephalitis localised in the brain stem and of indetermined etiology. 6 cases].

The authors report six cases of encephalitis localised in the brain stem. This disease occurred frequently during 1975, with the following symptoms and signs: fever, paralysis of several cranial nerves, temporary mental disturbance and C.S.F. changes. Several patients required tracheotomy and aritificial respiration. All patients recovered without any recurrences. Viral studies were negative. The possibility of a Listeria infection cannot be entirely eliminated.

Acute Disease↗
PubMedDate not supplied

The role of prostaglandins in the study of intestinal water and electrolyte transport in man.

The objective of this paper is to assess current knowledge on the pharmacologic and presumed physiologic effects of prostaglandins (PGs) on water and ion transport in the human intestine, from data in the literature and results of authors' studies. PGs, when administered intraluminally or intravenously, induce a profuse net secretion of water and ions into the jejunum or ileum; there is evidence that this effect is unrelated to changes in motility but due to a direct interaction of PGs with mucosal transport processes. Relations of PGs to cholera toxin, gastrointestinal hormones and adenylate cyclase-cyclic AMP system are reviewed. We propose to consider PGs as one of the most convenient model for studying intestinal secretion in vivo in man, in view of the rapid onset, magnitude, reversibility and reproducibility of their striking effect on mucosal transport.

Adenylyl Cyclases↗