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Biomedical subjects

S Curran

Publications and source records attributed to S Curran.

At least 19 recordsLinked to original sources
PubMed1999

Matrix metalloproteinases in tumour invasion and metastasis.

The matrix metalloproteinases (MMPs) are a large family of proteolytic enzymes, which are involved in the degradation of many different components of the extracellular matrix. The MMPs have been classified into different groups including collagenases, gelatinases, stromelysins, and others, particularly membrane-type MMPs, based mainly on the in vitro substrate specificity of individual MMPs. There is increasing evidence to indicate that individual MMPs have important roles in tumour invasion and metastasis. However, the current concept of the role of MMPs in tumour invasion is that they not only have a direct role in tumour invasion by facilitating extracellular matrix degradation, but as a consequence they also have an important role in maintaining the tumour micro-environment and thus promoting tumour growth. Inhibiting the action of MMPs represents a new therapeutic approach for the treatment of individual types of cancer and several broad-spectrum, low-molecular-weight MMP inhibitors are currently being assessed for clinical use. This review examines the role of MMPs in tumour invasion and metastasis, with an emphasis on studies of clinical relevance.

Humans↗
PubMed1999

Psychopathology 8 1/2 years post parasuicide.

There are few long-term follow-up studies of parasuicides incorporating face-to-face interviews. To date no study has evaluated the prevalence of psychiatric morbidity at long-term follow-up of parasuicides using diagnostic rating scales, nor has any study examined parental bonding issues in this population. We attempted a prospective follow-up of 85 parasuicide cases an average of 8 1/2 years later. Psychiatric morbidity, social functioning, and recollections of the parenting style of their parents were assessed using the Clinical Interview Schedule, the Social Maladjustment Scale, and the Parental Bonding Instrument, respectively. Thirty-nine persons in total were interviewed, 19 of whom were well and 20 of whom had psychiatric morbidity. Five and died during the follow-up period, 3 by suicide. Migration, refusals, and untraceability were common. Parasuicide was associated with parental overprotection during childhood. Long-term outcome is poor, especially among those who engaged in repeated parasuicides.

Adolescent↗
PubMed1998

Selecting an antidepressant for use in a patient with epilepsy. Safety considerations.

Depression is a common and disabling condition and is especially disabling for patients who also have epilepsy. Antidepressants, particularly the tricyclic antidepressants are well known to be associated with seizure activity, but this is a very neglected area of research. Most of the data on the proconvulsive effects of antidepressants come from either work in animal models or from research into the effects of antidepressants in overdose. Both of these situations may tell us little about the behaviour of antidepressants in patients with epilepsy. The selective serotonin [5-hydroxytryptamine; 5-HT] reuptake inhibitors have a low seizure propensity, are well tolerated in overdose and have a favourable adverse effect profile, making them suitable as first line treatments for depression in patients with epilepsy. Other antidepressants, e.g. trazodone, moclobemide, mirtazepine, are also likely to have minimal proconvulsive effects, but adverse effects, interactions with other drugs, especially anticonvulsants, or the lack of clinical data may make their use less attractive. Although this review has focused on these clinically important issues it is clear that considerably more research needs to be undertaken on the seizure propensity and clinical efficacy of antidepressants in patients with epilepsy.

Antidepressive Agents↗
PubMed1997

Distribution of putative primordial germ cells in equine embryos.

Eighteen equine embryos, 3 each on Days 20, 22, 24, 26, 28 and 30 post ovulation, were collected transcervically by uterine lavage, fixed in 4% paraformaldehyde and embedded in paraffin wax. Ten micron serial sections were stained to determine alkaline phosphatase (AP) activity in the cells. Positive cells were counted and their approximate location determined. The cells were approximately 8 microm in diameter and the entire cell, except the nucleus, stained strongly with many small round areas of intense staining in the cytoplasm. The cells varied from round to elongated in shape and pseudopodia were often present. Thus, they were similar in shape and staining pattern to primordial germ cells described in other species. A total of 2 AP-positive cells were found in the 3 Day 20 embryos and the mean number of AP-positive cells changed (P<0.05) over the succeeding days as follows; Day 20 = 1; Day 22 = 251; Day 24 = 1484; Day 26 = 2385; Day 28 = 3267; Day 30 = 2424. AP-positive cells present in the liver were not included in the calculations. In the Day 22 embryos, 10% of the putative primordial germ cells were found within the vascular system, including the heart chambers, and only 4% were found along the genital ridge. The percentage of cells found in the vascular system decreased from 10% on Day 22 to 1% on Day 30, although not significantly. The percentage of cells found along the genital ridge changed (P<0.05) over gestational age as follows; Day 22 = 4%; Day 24 = 10%; Day 26 = 28%; Day 28 = 28%; Day 30 = 16%. Once the putative primordial germ cells reached the developing gonads they were no longer AP-positive and nor was the gonadal stroma. The rest of the cells were distributed along the dorsal mesentery (range, 14-24%), near the dorsal aorta (16-29%), in the mesonephros (1-3%) and in other areas of the embryo (27-44%). Large numbers were in the cranial portion of the embryo. Although it is likely that the population of AP-positive cells counted included the primordial germ cells, other cells, such as haematopoietic precursor cells, could not be ruled out. The AP reactivity, the appearance of the cells and their migratory pattern through the dorsal mesentery to the gonadal ridge were consistent with descriptions of primordial germ cells in other species. Their distribution throughout the embryo, especially its cranial aspect and their location within, or in close proximity to, blood vessels suggested that the equine embryo is unusual among mammals in that some of its primordial germ cells migrate through the blood.

Alkaline Phosphatase↗
PubMed1997

Lewy bodies.

Explore the source record for details and available documents.

Alzheimer Disease↗
PubMed1995

The impact of a media campaign on public action to help maltreated children in addictive families.

Developed because of the need to promote public understanding of the link between addictions and child maltreatment, a multimedia campaign helped to increase by 62% the average monthly number of people who called a telephone service for information about how to aid abused and neglected children. The campaign was supported by market research and professional experience that indicated the campaign should focus on easy action a citizen could take, avoid inducing fear or blame, and target third party helpers and younger families-at-risk. Campaign exposure was promoted through the support of corporate partners. A random household survey found that 61% of the general population had seen or heard the campaign slogan. The average monthly calls to the child maltreatment information service regarding alcohol and other drug abuse tripled and the requests regarding at-risk children almost doubled. An auxiliary project provided interprofessional education to increase the probability that people seeking help would get it when referrals were made. The project yielded several lessons for future public awareness campaigns: focus on helping action rather than the problem; use of client-based market research; a strategic plan to assure necessary exposure; reliance on public-private-nonprofit sector partnerships; preparation of the service system; promotion of personal ways of helping.

Alcoholism↗
PubMed1995

Effect of paroxetine on seizure length during electroconvulsive therapy.

This study reports the effect of paroxetine, a selective serotonin reuptake inhibitor, on seizure length during electroconvulsive therapy. Seven inpatients taking paroxetine were compared with 7 controls taking tricyclic antidepressants. The mean seizure length of the paroxetine group was approximately twice that of the control group.

Adult↗
PubMed1995

Attachment site specificity and the tapeworm assemblage in the spiral intestine of the blue shark (Prionace glauca).

The parasite assemblage in the scroll-type spiral intestine of 24 specimens of the blue shark Prionace glauca collected off of Montauk, Long Island, New York was investigated. When opened with a longitudinal incision to the right of the ventral blood vessels, the internal mucosal spiral of the spiral intestine of the blue shark could be unrolled into a flat sheet of double-sided mucosal tissue. Attachment sites and parasite assemblages were studied on both sides of the sheet in 12 sharks and on either the inside or the outside of the sheet in 12 additional sharks. Assemblages within host individuals were composed of up to 4 species of tetraphyllidean cestodes including the onchobothriid Platybothrium auriculatum, and the phyllobothriids, Prosobothrium armigerum. Paraorygmatobothrium prionacis, and Anthobothrium laciniatum. Each individual shark hosted 1-4 tapeworm species (mean = 3.7 +/- 0.65). The 12 sharks in which both sides of the mucosal scroll were examined hosted 156-2,382 (mean = 929.1 +/- 818) individual tapeworms. The assemblage consisted of 4 core species. Sharks were not found to host all of the possible combinations of species in their assemblages; the most common combination (17 out of 24 individuals) was the occurrence of all 4 parasite species. A chi-square test revealed no evidence that the 4 species did not occur independently. Regression revealed a significant relationship between shark total length and spiral intestine area. Analysis of covariance (ANCOVA) revealed a significant difference between the surface areas of the 2 sides of the mucosal sheet when shark total length was taken into account.(ABSTRACT TRUNCATED AT 250 WORDS)

Analysis of Variance↗
PubMed1991

Pharmacodynamic effects of buspirone and clobazam.

1. The pharmacodynamic effects of buspirone and clobazam were compared in two volunteer studies. Acute doses of buspirone 5 mg, 10 mg and clobazam 10 mg were contrasted with placebo and a verum (lorazepam 1 mg), in a repeated measures design with 10 subjects assessed on a battery of psychometric tests at 1.5, 3.5, and 5.5 h post dose. For the combined results clobazam and the lower dose of buspirone (5 mg) were significantly contrasted with lorazepam on measures of subjective sedation, memory and choice reaction time (CRT). The higher dose of buspirone was not statistically different from lorazepam for all measures except memory; whilst contrasting significantly with placebo and clobazam on movement and total reaction time components respectively. Though failing to achieve significance, a similar trend was seen for critical flicker fusion (CFF) with buspirone 10 mg and lorazepam producing the lowest scores indicative of increased sedation. 2. Repeated doses of buspirone 5 mg twice daily, clobazam 10 mg twice daily, or placebo twice daily for 8 consecutive days were compared on the same battery of psychometric tests in a repeated measures design. Nine subjects were assessed on days 1, 3, and 8 of the study. Overall, memory performance significantly decreased with buspirone 5 mg in contrast to both clobazam and placebo whilst the opposite trend was seen with CFF. Clobazam significantly improved TRT in contrast to both placebo and buspirone. 3. These results indicate improved reaction time and memory performance with repeated dosing of clobazam in contrast to buspirone. Impairment following acute administration of buspirone appears limited to the higher (10 mg) dose.

Adult↗
PubMed1991

Effects of topical administration of levocabastine on psychomotor and cognitive function.

The possible central nervous system effects of topical administration of levocabastine, a new H1-antagonist, were investigated in a double-blind, placebo-controlled, crossover study using a battery of objective and subjective tests. These were carried out in 12 volunteers up to five hours postapplication. Neither the recommended (0.5 mg/mL) nor the four times higher (2.0 mg/mL) concentration level was found to be distinguishable from placebo, while the verum (triprolidine 10 mg) was significantly worse, on both objective and subjective measures.

Administration, Topical↗
PubMed1987

Plasma haloperidol and clinical response: a role for reduced haloperidol in antipsychotic activity?

Seventeen hospitalized psychotic patients were treated with a fixed oral dose of haloperidol, 5 mg twice daily for 28 days. Most were chronic schizophrenics with an acute exacerbation of their illness. All patients also received benztropine 3 mg twice daily during the last 11 days of the study, regardless of the presence or absence of extrapyramidal side effects. No significant linear or curvilinear relationship was found between steady state plasma levels of haloperidol and clinical response measured by total Brief Psychiatric Rating Scale score. At 28 days, the correlations between plasma levels and percent improvement were rs = 0.187 (not significant) for haloperidol and rs = 0.582 (p = 0.04) for the hydroxymetabolite, reduced haloperidol. The correlation for the sum was rs = 0.511 (p = 0.078). Metabolite levels were substantially higher than plasma haloperidol, on the average 2.7 times greater. Eleven days of benztropine treatment had no significant effect on haloperidol or metabolite plasma levels or on clinical status. At the end of the study, nine of 17 patients (53%) had recovered as judged by discharge readiness. Within the limitations implied by the small number of patients, these data suggest that reduced haloperidol is an important component of plasma antipsychotic activity and cannot be neglected in correlative studies, and that a substantial proportion of patients--about half--can be successfully treated with only 10 mg of haloperidol. The routine use of large doses is thus not necessary for many patients.

Adult↗