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S D Baker

Publications and source records attributed to S D Baker.

40 records · Page 3Linked to original sources
PubMed1992

Intern orientation: obstacle or opportunity?

Orientation programs for medical interns generally bombard new physicians with a barrage of information from the hospital director of medical education, the chief executive officer, and other hospital personnel, as well as from a number of outside speakers. Advanced cardiac life-support training and social events round out the orientation program, which typically lasts 3 to 4 days. The authors propose a three-phase orientation program that begins even before the intern reports for duty and continues for an estimated 6-month period thereafter. This seemingly long-term time investment will foster good relations between employer and employee, thereby helping to encourage the intern to stay on as a resident and staff physician. Such commitment can only enhance the growth of the osteopathic medical education programs.

Inservice Training↗
PubMedDate not supplied

Organizational effectiveness: toward an integrated model for schools of nursing.

Assessing the quality of academic institutions involves much more than the opinions of peers or experts. Examination of the organizational effectiveness of schools of nursing has been neglected. Current emphasis on assessing educational outcomes has diverted attention from the construct, organizational effectiveness, and more comprehensive theory-driven approaches to evaluation. This review of the organizational effectiveness literature focuses on the major assessment models: goal attainment, human relations, open systems, internal processes, culture, and life cycle. Attention is given to the influence of organizational maturation on an integrated model of organizational effectiveness. Selected macrolevel studies of schools of nursing are examined, and an agenda for nursing research is proposed.

Education, Nursing↗
PubMedDate not supplied

Drug interactions with the taxanes.

Interactions may occur when the taxanes paclitaxel and docetaxel are given concurrently with other drugs. Altered clearance may be expected because these agents are extensively metabolized by hepatic cytochrome P-450 enzymes, particularly isoenzymes 3A and 2C. Pharmacodynamic interactions that alter the molecular target or pharmacology of a drug may depend on the sequence or schedule of administration. Paclitaxel clearance is reduced when cisplatin precedes paclitaxel, although cisplatin does not affect the metabolism of paclitaxel by human liver microsomes. Measurement of DNA adduct levels in peripheral white blood cells indicates that a pharmacodynamic interaction may occur between cisplatin and both taxanes. The pharmacokinetics of carboplatin and paclitaxel were not altered when the drugs were given in combination; however, a pharmacodynamic interaction may explain the decreased frequency of thrombocytopenia compared with single-agent carboplatin. When paclitaxel precedes cyclophosphamide, myelosuppression is more severe. In contrast, when docetaxel precedes ifosfamide, toxicity is reduced. The mechanisms for these effects is unknown. With combination paclitaxel and doxorubicin regimens, the schedule of paclitaxel and the sequence of the agents may result in both pharmacokinetic and pharmacodynamic interactions.

Animals↗