PubMed Health⌕ Search

Biomedical subjects

S D Freedman

Publications and source records attributed to S D Freedman.

48 records · Page 3Linked to original sources
PubMed1977

Possible role of calcium-dependent protein phosphorylation in mediating neurotransmitter release and anticonvulsant action.

The results demonstrate that calcium and phenytoin have antagonistic actions on the net level of endogenous phosphorylation of specific rat brain proteins. These specific phosphoproteins were shown to be present in synaptosome preparations, and evidence is presented for the localization of these phosphoproteins within the presynaptic nerve terminal. The data are compatible with the hypothesis that the antagonistic actions of calcium and phenytoin on the phosphorylation of synaptosome proteins may be the underlying molecular mechanism mediating the opposing actions of these agents on the release of neurotransmitter from the presynaptic nerve terminal.

Animals↗
PubMedDate not supplied

Endoscopic therapy of chronic and recurrent pancreatitis.

Endoscopic pancreatic therapy is emerging as an exciting nonoperative alternative in the management of chronic pancreatitis, in particular in cases where pancreatic duct obstruction due to stones, protein plugs, or strictures is present. Although the preliminary results available are promising, prospective randomized trials comparing endoscopic and surgical techniques are much needed. Furthermore, the published data come from large endoscopic centers with very high levels of technical skill and experience, and, therefore, its wide-spread clinical use is limited. Time and well-designed prospective randomized clinical trials comparing surgical versus endoscopic techniques will help define the role of these procedures in the treatment of chronic pancreatitis.

Cholangiopancreatography, Endoscopic Retrograde↗