Serious cardiac abnormalities and asymptomatic hyperkinetic heart function are frequently seen in patients with polymyositis/dermatomyositis (PM). The cardiac manifestations may be secondary to myocardial inflammation, replacement fibrosis, or alterations in the peripheral circulation. The significance of determinations of cardiospecific isoenzymes in the evaluation of myocardial manifestations in PM has not yet been established. We report on 2 patients with firm evidence of severe myocardial involvement. Nevertheless, the serum levels of creatine phosphokinase MB (CPK MB) and lactated dehydrogenase isoenzyme 1 (LDH1) were found normal. This finding casts doubt on the reliability of cardiospecific isoenzymes for the identification of inflammatory myocardial involvement in patients with PM.

Aged↗

PubMed1984

[Complications, mortality and time of discharge in acute myocardial infarct].

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Adult↗

PubMed1983

Cardiac conduction disturbances during carbamazepine therapy.

3 cases of carbamazepine (CBZ)-induced Stokes-Adams attacks caused by intermittent total atrioventricular block, sino-atrial block with junctional escapade-rhytm and intermittent asystolia are reported. After cessation of CBZ treatment, the cardiac conduction disturbances disappeared. In 2 of the patients, the diagnosis was confirmed by resumption of treatment with CBZ after insertion of a demand pacemaker. If syncopes or changes in seizure-type occur in patients treated with CBZ, evaluation of cardiac conduction is recommended. Furthermore, it is recommended that cardiac function is evaluated before CBZ-treatment, especially in elderly patients.

Aged↗

PubMed1982

Total atrioventricular block with syncopes complicating carbamazepine therapy.

At case of carbamazepine-induced intermittent total atrioventricular block with asystole and Stokes-Adams attacks is reported. The diagnosis was proved by repeated administration of carbamazepine after insertion of a demand pacemaker. If syncopes occur or change nature in a patient treated with carbamazepine, evaluation of cardiac conduction is recommended.

Adams-Stokes Syndrome↗

PubMed1981

Reversible dementia in idiopathic hypoparathyroidism.

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Aged↗

PubMedDate not supplied

Expression of the intercellular adhesion molecule-3 (ICAM-3) in human renal tissue with relation to kidney transplants and various inflammatory diseases.

Adhesion molecules are important for immune regulatory mechanisms concerning antigen presentation, lymphocyte activation, localisation and migration as well as effector-target cell interactions in inflammatory processes. The immunohistochemical expression of ICAM-3, a recently cloned new member of the immunoglobulin family which also binds leucocyte function antigen 1 (LFA-1), was examined in 80 needle core biopsies from 35 renal allografts, 7 patients with mesangioproliferative glomerulonephritis, 5 patients with extracapillary glomerulonephritis, 4 patients with interstitial nephritis and 5 patients with diabetic nephropathy and 20 normal kidneys. In all types of lesions ICAM-3 was constitutively expressed on the majority of infiltrating leucocytes without detectable upregulation or presentation on possible target structures during inflammation indicating its possible role to be mainly in initiation of the inflammatory response.

Antigens, CD↗