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Biomedical subjects

S D Marston

Publications and source records attributed to S D Marston.

9 recordsLinked to original sources
PubMed1974

Asymptomatic infection with EB virus.

Evidence of asymptomatic EB virus infection was sought in healthy medical students and nurses following the observation that 1.4% possessed heterophile antibodies. The proportion of subjects with EB virus antibodies rose with age and there was evidence of recent infection in 19%. Smooth muscle antibodies were detected in 13 individuals and recent infection with EB virus was probable in six of these. Subclinical EB virus infections, in some cases associated with some disturbance of immunological function, may therefore be not uncommon in young adults.

Adolescent↗
PubMed1972

A 'virus-free' cell line derived from a patient with infectious mononucleosis.

A continuous cell culture line, derived from a nurse with infectious mononucleosis, is described. Electron microscopic and immunofluorescent examination suggested that it was substantially free from detectable complete virus particles, although the presence of a soluble complement-fixing antigen showed the persistence of other antigenic components of the EB virus.

Adult↗
PubMed1971

Some observations on complement-fixing antibodies to the EB virus.

Complement-fixing antibodies against an antigen prepared from the EB3 line of cultured Burkitt tumour cells were studied in various groups of patients and control individuals. Higher antibody titres were observed in patients with Burkitt's tumour than in African patients with other diagnoses. Significantly more medical students and nurses with a history of infectious mononucleosis possessed antibodies than those with no such history. Low levels of antibody were observed in patients during the acute phase of infectious mononucleosis and these levels were significantly lower than those in patients admitted to the same hospital with other diagnoses. During the early months following the acute phase of illness, EB complement-fixing antibodies remained stationary or apparently declined in titre but, in patients tested one or more years later, significantly higher antibody levels were observed.

Antibodies↗