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Biomedical subjects

S D Mok

Publications and source records attributed to S D Mok.

12 recordsLinked to original sources
PubMed1990

Simultaneous determination of conjugated bile acids in human bile.

We describe an optimized liquid chromatographic method for simultaneous analysis of 10 conjugated bile acids in gall bladder and ductal bile. A quick and effective one-step purification with Sep-pak C-18 was adopted. We used a reverse phase C18 stainless steel column and an isocratic mobile phase in a flow programme and monitored the column effluent at 205 nm. The within-day CV ranged from 0.3 to 1.8%, and the between-day CV from 1.2 to 7.2%. Absolute analytical recovery ranged from 89 to 107%. Linearity ranged from 0.3 to 3 mg/mL for most bile acids. The chromatographic analysis was completed in 18 min.

Aged↗
PubMed1990

Sonographic diagnosis of portal vein invasion in patients with hepatocellular carcinoma: comparison with arterial portography.

The results of sonographic assessment of the main portal vein were compared with arterial portography in 65 patients with documented hepatocellular carcinoma. When compared with fully-diagnostic angiograms, obtained in 54 patients, sensitivity of ultrasound was 64% with a specificity of 98%. We conclude that ultrasound is a valuable first-line method of detecting portal vein invasion in the preoperative assessment of patients with hepatocellular carcinoma.

Adolescent↗
PubMed1990

Migrated tumour fragments in common bile ducts from hepatocellular carcinoma.

Death from hepatocellular carcinoma (HCC) is often heralded by the appearance of jaundice which is usually the result of extensive parenchymal damage from either progressive cirrhosis or diffuse tumour infiltration. In rare cases, patients with HCC may present with obstructive jaundice caused by migrated tumour fragments in the common bile ducts. We report three such patients. One patient underwent repeated palliative surgical and endoscopic procedures to clear the bile ducts of tumour fragments. He returned to a normal life but finally succumbed to the disease 17 months after diagnosis. Two patients underwent major hepatic resection after initial tube decompression of the obstructed bile ducts. One patient was found to have recurrence of the tumour 17 months after surgery and the other patient was well and disease-free 24 months after surgery. It is important to recognize and treat this group of patients with migrated tumour fragments in the common bile ducts, as good palliation and occasional cure are possible.

Adult↗
PubMed1989

Is reperitonealization of the gallbladder bed a ritual or necessity?

Reperitonealization of the gallbladder bed after cholecystectomy is the standard procedure described in many textbooks of surgery. Most surgeons who advocate nondrainage after cholecystectomy also routinely obliterate the gallbladder bed. The theoretic considerations are a decrease in post-operative drainage and avoidance of adhesions to the liver. To evaluate the validity of the first consideration, 88 patients undergoing elective cholecystectomy were randomly allocated into two groups. In the first group, the gallbladder bed was reperitonealized whereas in the second group, the raw surface was left uncovered. No significant difference in the amount of postcholecystectomy drainage could be demonstrated in the two groups of patients studied.

Adult↗
PubMed1989

Simplified hepatectomy: the tourniquet method.

A method to control bleeding from the transected liver parenchyma during hepatectomy is described. The merits of this tourniquet method are its simplicity and versatility. It is inexpensive, can be applied rapidly and performed readily. Hepatic transection, particularly in a cirrhotic liver, can be effected with a substantial reduction in blood loss.

Evaluation Studies as Topic↗
PubMedDate not supplied

Endoscopic removal of large common bile duct stones in recurrent pyogenic cholangitis.

It is not uncommon to find large stones obstructing the bile duct in patients with recurrent pyogenic cholangitis. In a series of 291 patients with cholangitis, 32 patients had stones more than 2 cm in diameter. Endoscopic extraction using a combination of large baskets, 1% EDTA flushing, and manual or mechanical lithotripsy allowed the common bile duct to be cleared in 50% of patients. Lack of space in the common bile duct to open the retrieval basket because of stone impaction was the major reason for failure.

Adult↗