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Biomedical subjects

S D Pandey

Publications and source records attributed to S D Pandey.

At least 37 records · Page 2Linked to original sources
PubMed1990

Role of photoperiod and temperature in production of the oestrus-inducing pheromone in male wild mice.

Ninety adult males divided in six equal groups were exposed to different photoperiods for 21 days. Exposures included natural light (ca 11 hr), long photoperiod (16L:8D) and short photoperiod (8L:16D). The first three groups received these exposures at room temperature (13-20 degrees C) while the remaining three at raised temperature (36-38 degrees C). Soiled bedding of the above males was introduced in the cages of unisexually housed noncyclic females and their potentiality to induce oestrus was assessed. It was noticed that the bedding of all the males proved to be a stimulus inducing oestrus in the majority of the females during the 7 day exposure. There was no significant difference in the number of females returning to oestrus following exposure to soiled bedding of different males. These results elucidate that environmental factors, especially light and temperature do not influence the production/release of the oestrus-inducing pheromone in wild mice.

Animals↗
PubMed1989

Documentation of the first web space angle.

We describe a new method of measuring adduction contractures of the thumb by using stent mould casts of the first web, which are sectioned sagittally to give an accurate clinical angle at their cut section. This can be recorded from ink impressions. This method has been used successfully in 65 cases and appears more accurate than other methods.

Casts, Surgical↗
PubMed1989

Study of maternal behaviour in wild mice: avoidance to retrieve young and increase in cannibalic activity.

Pregnant females trapped from the wild were watched daily for parturition. Postpartum-retrieving reaction tests were carried out with all mothers using their own, alien or mixed pups. All the females when release in the cage for testing roamed around the cage but did not tend to retrieve any of the pups. Females frequently sniffed their own pups as well as alien ones without displaying any discrimination. However, when these females were left with their pups for rearing after the tests, they tended to cannibalize the latter. These findings indicate the absence of maternal retrieving in wild species of Mus, at least, under laboratory conditions.

Animals↗
PubMed1988

Male-induced puberty acceleration in young female wild mice: hormonal regulation and source of pheromonal cue.

Experiments were designed to examine the influence of adult males on the rate of sexual maturation in young female wild mice. In one experiment, young females were raised in presence of adult males, adult females and in absence of any individual, while in another, they were exposed to urines of: (1) castrated males, (2) spayed females, (3) castrated and TP-treated males, (4) castrated and placebo-injected males. Female maturation as measured by age at vaginal opening and first vaginal oestrus was accelerated by presence of adult males, whereas presence of adult females considerably delayed the vaginal opening and the appearance of first oestrus in young females. In the other set of the experiments, urine from castrated or castrated and placebo-injected males was ineffective in inducing early puberty while urine from spayed females highly delayed the sexual maturation. By contrast, urine from castrated and TP-treated males accelerated the puberty more or less like normal males. The results indicate that male's chemosignal accelerating puberty in young females is present in urine and its production is under the control of androgens. However, the female-originating urinary pheromone which delays the puberty in young females is not regulated by ovarian hormones.

Animals↗
PubMed1987

Alkaline phosphatase as a model for studying metal-protein interactions in pulmonary toxicity.

An attempt has been made to study the biochemical properties of lung alkaline phosphatase so that it may serve as a model for measuring the toxicity of air pollutants, especially metals. Lung was shown to be a better source of this enzyme in comparison to other organs in rats. The optimum pH, metal requirements, substrate specificity, and affinity constants were characterized with different substrates, and the effect of different metals was studied. The involvement of zinc in the lung enzyme was not indicated as shown by Sephadex G-200 elution profile of postmitochondrial supernatant of 65Zn-treated animals.

Alkaline Phosphatase↗
PubMed1986

Effect of intratracheal injection of zinc oxide dust in guinea pigs.

Intratracheal injection of zinc oxide dust, a component of many cosmetic preparations caused elevation of alkaline phosphatase and lactate dehydrogenase in serum and lung of guinea pigs. Clearance of zinc oxide dust from lungs through zinc-carrying proteins was evident.

Alkaline Phosphatase↗
PubMed1986

Oestrus suppression in wild mice: source of pheromonal cue.

Regularly cycling female mice attained anoestrus when they were exposed to voided urine or to urine directly collected from the bladder of intact females. In contrast, the urine of spayed females or the clitoral gland homogenate from intact females was found ineffective in suppressing oestrus. The findings thus clearly elucidate the presence of an oestrous-suppressing pheromone in the urine of intact females whether voided or collected directly from the bladder and confirm the oestrogen dependence of the pheromone. Clitoral glands do not seem to have a role in production of this pheromone.

Animals↗
PubMed1979

Failure of deodorized males to induce oestrus in the wild mouse.

The ability of female mice to return to oestrus following exposure to males perfumed either with oil of wintergreen or with the commercial perfume, "Kanta" was evaluated. Unisexual grouping of female mice induced anoestrus in all individuals. Oestrus was, however, promptly induced in the majority of unisexually grouped females by exposure to normal males. By contrast, exposure to perfumed males failed to induce oestrus in unisexually grouped females. The results suggest that male urine which is the source of the primer pheromone involved in the induction of oestrus was ineffective because of the masking effect of artificial scents. Hence the unisexually grouped females were unable to perceive the pheromone from males and continued to remain in anoestrus following exposure to perfumed males. The results provide additional evidence in support of the view that the urinary pheromone produced by males induces oestrus in females by acting through olfactory pathways.

Animals↗
PubMed1979

Suppression of oestrus-inducing pheromone production in the Indian field mouse, Mus booduga Gray, by treatment with an antiandrogen.

The effect of cyproterone acetate (CA) on the production of the male-originating oestrus-inducing pheromone in the Indian field mouse, Mus booduga Gray was investigated. The anoestrus induced in regularly cycling females by unisexual grouping was reversed by exposure to intact males. The majority of male-exposed females returned to oestrus within seven days, with a peak on the fourth-day. By contrast, exposure to CA-treated males failed to induce oestrus in grouped females. Since CA is a potent antiandrogen, the inability of CA-treated males to induce oestrus in females is interpreted as due to the depression of the production of the androgen-dependent pheromone. The results provide evidence in favour of the concept that the oestrus-inducing pheromone in the Indian field mouse is associated with androgens either directly or indirectly through some androgen-dependent gland.

Animals↗