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S D Pogosbekova

Publications and source records attributed to S D Pogosbekova.

5 recordsLinked to original sources
PubMed1975

[Phospholipids and thromboplastins in various sections of the brain normally and in excitation states].

The level of the neutral and acid phospholipids and thromboplastic activity of various portions of the rabbit brain were studied under normal conditions and following adrenaline stimulation. The level of total phospholipids, neutral phospholipids, and the ratio of neutral to acid phospholipids, thromboplastic activity and its increase following incubation of homogenates of the brain tissue of normal and adrenaline-treated animals were found to be distributed in the following descending order: the medulla oblongata, cerebellum, cerebral hemispheres. Adrenaline decreased the thromboplastic activity and induced changes in the neutral and acid phospholipid levels. The role of phospholipids in the biosynthesis of various components of the blood clotting and anticoagulant systems are discussed.

Animals↗
PubMed1975

Mechanism of cardiotonic action of monoethanolamine and its activity in experimental myocardial hypertrophy.

The authors investigated the cardiotonic effect of monoethanolamine (MEA) and its influence on experimental cardiac hypertrophy in albino rats. In isolated hearts, myocardial cells, and glycerinized fibres as well as in the whole organism of the animals, a distinct cardiotonic effect on MEA was observed, which was most marked in pathological states of the organism. In rats with experimental coarctation of the aorta, MEA dosed 10 mg/kg stimulated, and dosed 60 mg/kg, inhibited the development of myocardial hypertrophy, while the myocardial contractility remained sufficiently preserved. The mechanism of cardiotonic action and the inhibitory effect on the development of myocardial hypertrophy at the dosage of 60 mg/kg are apparently connected with the participation of MEA in tissue metabolic processes contributing to a normalization of tissue respiration, oxidative phosphorylation, and activation of phosphatide-generating reactions, especially to the formation of phospholipids containing ethanolamine, which represent one of the most important membrane formations and components of numerous enzymic systems.

Animals↗
PubMed1974

[Relationship between thromboplastin activity in different brain structures and the quantitative interrelationships of functionally different groups of phospholipids in them].

The microsomal fraction of rabbit brain has the highest content of phospholipids and is completely devoid of polyglycerophospholipids. The decrease of the ratio of neutral to acid phospholipids is accompanied by a corresponding reduction of thromboplastic activity. Thromboplastic activity is high in the nuclear fraction of the medulla oblongata, cerebellum and cerebral hemispheres. Adrenaline reduces the amount of both total and individual phospholipids (mainly neutral) in subcellular particles of brain. This is accompanied by reduction of thromboplastic activity. The incubation of homogenates of brain parts for 2 hrs in the presence of glucose brings to the increase of phospholipids in the incubation medium and enhancement of thromboplastic activity.

Animals↗
PubMedDate not supplied

[Changes in phospholipid metabolism in subcellular structures of cardiac muscle of rabbits with experimental myocardial infarction].

Alteration in phospholipid turnover was studied in subcellular structures (nuclei, mitochondria, microsomes) of rabbit heart muscle within various postinfarctional periods (7, 14 and 21 days). The specificity of alterations in phospholipids as well as dissimilar direction of the alterations were observed in different subcellular structures of heart cells under conditions of myocardial infarction. Administration of etpenale contributed to increased synthesis of phospholipids (especially in mitochondrial fraction) with subsequent trend to normalization.

Animals↗