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Biomedical subjects

S D Riccitelli

Publications and source records attributed to S D Riccitelli.

3 recordsLinked to original sources

The PB3300 intraarterial blood gas monitoring system.

Continuous intraarterial blood gas (IABG) monitoring is in clinical use both in the operating room and intensive care unit. This technology uses miniature, optically-based sensors that can be placed into a patient's artery. The arterial blood gas values are transduced into an optical signal that is measured by a bedside monitor on which the values are displayed. In this paper, we describe the operating principles of the PB3300 Intra-Arterial Blood Gas Monitoring System (Puritan-Bennett Corporation, FOxS Division, Carlsbad, CA). Topics include the principles of fluorescent determinations of pH, PCO2, and PO2; the optical path of the PB3300; system calibration; dye layer geometry; and clinical operation. The accuracy, precision, and drift of the system measuring tonometered aqueous standards are reported. The following values were noted for eight sensors sending data to eight monitors: system bias and precisions of 0.00 +/- 0.02 pH at a pH of 7.40, -2.5 +/- 1.5 mm Hg PCO2 at a PCO2 of 40 mm Hg, and 3.3 +/- 1.3 mm Hg PO2 at a PO2 of 80 mm Hg.

Blood Gas Analysis↗

Albumin coatings resistant to shear-induced desorption.

Using an immunoferritin-transmission electron microscopic technique, we studied the effects of C18 alkylation and fluid shear on the distribution of albumin absorbed to a segmented polyether polyurethane. Samples were exposed to 25 mg/dl albumin solution at 0, 100 or 1500 s-1 wall shear rate for 1 min. Others underwent static incubation with albumin solution for 20 mins, followed by exposure to phosphate buffered saline at 0, 100 or 1500 s-1 for 1 min. Significant increases in uniformity and density of the albumin adsorbate were observed for all C18 alkylated surfaces, at all wall shear rates. C18 alkylation also significantly decreased the rate of shear-induced desorption of albumin. Results suggest that C18 treatment may promote the rapid development and retention of an endogenous albumin layer for blood contacting materials.

Adsorption↗