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Biomedical subjects

S D Rolih

Publications and source records attributed to S D Rolih.

6 recordsLinked to original sources
PubMed1989

High-titer, low-avidity (HTLA) antibodies and antigens: a review.

Antibodies that react to HTLA characteristics cause difficulties in serologic testing because of the weak reactions they produce in the indirect antiglobulin test. Those specificities that are more frequently encountered (anti-Yka, -McCa, -Kna, -Ch) are directed toward antigens of high incidence in both the white and black populations. They have not been shown to cause significant destruction of transfused antigen-positive red cells. The antibodies create problems in serologic tests because the reactions they produce interfere with the identification of reactions due to other, clinically significant antibodies.

Antigens↗
PubMed1976

Failure to demonstrate dosage of U antigen.

Tests in which 11 examples of anti-U were used in titration studies against the red blood cells of 9 obligate Uu heterozygotes, from 4 unrelated families, and random Negro and Caucasian donors (many of whom were of the presumptive UU genotype) have failed to demonstrate any dosage of the U antigen.

Black People↗
PubMedDate not supplied

Autoantibodies mimicking alloantibodies.

A patient with myelofibrosis, who has produced many red blood cell autoantibodies, is described. Although the patient is phenotypically R1R1 (CDe/CDe), eluates made from his red blood cells have consistently contained what appeared to be anti-E, and more recently another antibody that appeared to be anti-c. In in vitro experiments we have shown that the "anti-E" and "anti-c" can be totally adsorbed by E-negative and c-negative red blood cells, respectively. We conclude that the two antibodies have quite different specificities from those indicated by simple antibody identification studies, and that both are more closely related to the anti-Hr series of antibodies than to anti-E or anti-c.

Adsorption↗
PubMedDate not supplied

Difficulty in LW typing as revealed by a family study.

A family is described in which two members of the second generation are of the phenotype LW3. In the course of the investigation the mother of the LW3 propositus was at first believed to be phenotypically LW3 as well. Eventually, it was shown that she is, in fact, phenotypically LW2 but that her R-1 (no D), LWlw, genotype had resulted in less LW being present on her red blood cells than is expected in LW2 persons. This reduced level of LW could not be detected with one example of anti-LW made by an LW3 individual.

Accidents, Occupational↗
PubMedDate not supplied

Studies on the blood of an MsHe/MSu proposita and her family. Serological evidence that Henshaw-producing genes do not code for the 'N' antigen.

The serum of a black woman has been found to contain a potent alloanti-N that reacted in direct agglutination tests with the 'N' antigen carried on Ss-active sialoglycoprotein. Thus far, such antibodies have been observed only in the sera of MSu/MSu individuals. However, our proposita had red cells that lacked 'N'. Her blood type was M+, N-, S-, s+, U+, He+. Results of family studies indicate that she is of the genotype MsHe/MSu. Our findings are consistent with recently reported data on the structure of the Henshaw antigen, which is located on a Ss-active sialoglycoprotein that does not carry 'N'.

Blood Group Incompatibility↗