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S Darwish

Publications and source records attributed to S Darwish.

30 records · Page 2Linked to original sources
PubMed1989

Helper inducer T cells in the lungs of sarcoidosis patients. Analysis of their pathogenic and clinical significance.

Phenotypic analysis of helper CD4+TQ1- cell population, the major helper T-cell subset for B-cell responses, was carried out in BAL fluid of sarcoidosis patients. Most of the BAL CD4+ cells lacked TQ1 membrane antigen. A correlation between the number of helper CD4+TQ1- cells and IgM and IgA levels was observed in 27 sarcoidosis patients' BAL. A role of CD4+TQ1- cells in modulating lung B-cell immunoglobulin secretion in sarcoidosis was confirmed by the fact that BAL IgG level and helper T-cell number correlated well in patients with low-intensity alveolitis. Results showed an inverse correlation between symptom duration and BAL IgM levels and CD4+TQ1- cell number. The number of helper cells was above normal in patients who had symptoms for less than 12 months and within normal range in those who had symptoms for more than that. The pathogenic and clinical relevance of these data is discussed.

Adult↗
PubMed1988

Treatment of advanced non-small cell lung cancer (NSCLC): the "Umbria" cooperative study.

One hundred fifty-six patients with metastatic or locally advanced non-small cell lung cancer (NSCLC) were randomized to 3-week cycles of treatment with either: (A) cisplatin (120 mg/m2 on day 1); (B) cisplatin (120 mg/m2 on day 1) plus etoposide (VP-16) (100 mg/m2 on days 1-3; and (C) the cisplatin plus etoposide (VP-16) regimen plus mitomycin C (10 mg/m2 on days 1, 21, and 42; then every 6 weeks for a maximum dose of 100 mg). The overall objective response rates for the combination regimens (30% with two drugs and 26% with three drugs) were superior to that obtained with one drug (4%). Likewise, the median duration of survival with the combination therapy arms (8 to 9 months) was superior to that obtained with the single agent (5 months). Both performance status and limited disease were correlated with response in all groups, and with survival in the combined chemotherapy arms. The dose-limiting toxicity was myelosuppression, especially for the group receiving the three-drug regimen. In summary, combination chemotherapy using cisplatin and etoposide (VP-16) appears to be the most active and safest regimen in NSCLC.

Aged↗
PubMed1988

Analysis of CD4-positive T cell subpopulation in sarcoidosis.

Double-labelling immunofluorescence analysis within the CD4+ cell subset was carried out in 27 bronchoalveolar lavage fluids and 11 peripheral blood samples of sarcoidosis patients with anti-TQ1, anti-2H4 and anti-4B4 monoclonal antibodies. Helper/inducer CD4+TQ1-/4B4+ cells were strongly increased in the lung and slightly, but significantly, decreased in the blood of sarcoidosis patients with respect to normal controls. No differences were found in the number of both lung and blood CD4+2H4+ cells between sarcoidosis patients and controls. The findings are further evidence for a compartmentalization of T cell subsets in sarcoidosis.

Adult↗
PubMed1984

Rate of viscosity changes in five salivary protein fractions following pH alterations.

The change of viscosity with time following alteration of pH was studied in five protein fractions isolated from human parotid saliva. The results indicate that sudden pH changes may cause rapid charge alterations leading to shock-like expansion or compression of the molecules. This quick reaction seems to be followed by more slowly proceeding conformational alterations probably involving folding, intermingling, and other types of chain interactions. The content of proline residues may influence the rate and extent of such conformational changes.

Humans↗
PubMed1984

Salivary viscosity and lubrication: influence of pH and calcium.

The viscosity of human whole saliva and six salivary protein fractions was studied at different pH levels in the presence and absence of calcium. Changes in pH significantly influenced the viscosity of whole saliva, and centrifugation and filtration removed one of the viscous components. Calcium depletion made the viscosity particularly susceptible to acidification. The protein fractions were obtained from pooled parotid saliva by ion exchange and gel permeation chromatography procedures. Except for a glycoprotein, these fractions generally exhibited the lowest viscosity in the pH region around their isoelectric points. Calcium generally increased the viscosity of these proteins.

Calcium↗