PubMed Health⌕ Search

Biomedical subjects

S Dekel

Publications and source records attributed to S Dekel.

66 records · Page 4Linked to original sources
PubMed1980

The effect of prostaglandins on sulphate and thymidine incorporation in pig cartilage.

Prostaglandins A1, A2, B2, E2, and F2 alpha inhibit glycosaminoglycan sulphation in pig costal cartilage discs above 0.1 micrometer M (5-25 ug/ml); no effects were found at concentrations down to 25 pg/ml. At concentrations above 1 microgram/ml (0.02 mM) prostaglandin E2 and F2 alpha inhibited cartilage DNA synthesis. However at 100 ng/ml (10 microM) this inhibition was again observed. The basal production of prostaglandins E2 and F2 alpha by the cartilage discs after incubation was below 15 pg/ml. The exact concentrations at which these inhibitory effects were observed varied from experiment (i.e. animal) to experiment.

Animals↗
PubMed1980

The effect of anti-inflammatory drugs on glycosaminoglycan sulphation in pig cartilage.

Indomethacin, aspirin and hydrocortisone have been shown to inhibit glycosaminoglycan sulphation in pig costal cartilage discs. The doses at which inhibition was observed varied from pig to pig from 0.1 - 50 microgram/ml for indomethacin, 40 - 150 microgram/ml for aspirin and 0.5 - 1 mg/ml for hydrocortisone, doses which are achieved clinically in the treatment of joint diseases. In a minority of experiments a significant stimulation of glycosaminoglycan sulphation was observed at lower doses of indomethacin and hydrocortisone but not aspirin. THe results suggest that in rheumatoid arthritis but more especially osteoarthritis, treatment with these drugs should aim at finding the lowest doses which have a therapeutic effect. As importantly the clinician should always consider using lower doses just as much as higher doses when the first dose regimen is unsatisfactory.

Animals↗
PubMed1980

Urinary prostaglandin E2 in acute bacterial cystitis.

The levels of prostaglandin E2 were studied in the urine of 14 female patients with acute bacterial cystitis. Ten healthy female students served as a control group. Results indicated a significant increase of urinary prostaglandin levels with a consistent relationship to the onset and duration of the clinical symptoms.

Acute Disease↗
PubMed1979

The production of prostaglandins in response to experimentally induced osteomyelitis in rabbits.

Osteomyelitis was induced in the tibiae of rabbits by injection of staphylococcus aureus and sodium tetradecylsulphate (STD); additional rabbits were injected with STD alone. Confirmation of osteomyelitis was based on positive culture of the same phage type bacteria from the tibiae and on the characteristic radiographical and histological appearance of osteomyelitis. Only tibiae which proved to be infected by the above criteria showed significantly increased in vitro release and content of Prostaglandin E and Prostaglandin F2 alpha compared with tibiae injected with STD (P less than 0.05). After two weeks infection, infected tibiae released nine times more Prostaglandin E and five times more Prostaglandin F2 alpha than tibiae injected with STD alone. After four weeks infection, infected tibiae released less Prostaglandin E (P less than 0.05) than after two weeks infection but the release of Prostaglandin F2 alpha was similar. The production of large amounts of prostaglandins by bones in response to infection may be the cause of the rapid bone resorption and sequester formation observed in osteomyelitis.

Animals↗
PubMed1979

[Treatment of fractures of the femoral neck by primary femoral prosthesis (author's transl)].

The authors have reviewed 230 case of fractures of the femoral neck treated by primary femoral prosthesis. The mortality was 12,6 p. 100 during the first three post operative months, and 16,5 p. 100 after three additional months. The infection rate was 13,9 p. 100, 4,7 p. 100 of the cases being severely infected. The postero lateral approach was more favourable than the antero-lateral approach. Late results were studied on 142 cases. The average follow-up was 4 years. The clinical results were closely dependent on the radiological appearance. When the prosthesis progressively penetrated into the femoral medullary canal incapacitating pain was always present. It is concluded that the use of cement may improve the results in a number of cases.

Aged↗
PubMed1978

Joint changes after overuse and peak overloading of rabbit knees in vivo.

The effect of overuse and overuse combined with axial peak overloading on the knee joints of living rabbits has been investigated. A specially constructed apparatus was used for this purpose. Physical and biochemical changes are reported and include: 1. Early and progressive damage to the articular cartilage surface shown by the scanning electron microscope. 2. The presence of an increased amount of prostaglandin E in the synovial fluid. 3. A reduction of cyclic 3'--5' monophosphate in the subchondral bone. 4. Late changes which were consistent with osteoarthritis. These changes were found only in the joints subjected to simultaneous overuse and peak overloading. The results suggest that: 1. Cartilage damage and chemical changes in the subchondral bone are simultaneous and are both responsible for eventual degenerative changes. 2. Frictional overuse alone does not seem to be responsible for the production of oesteoarthritis.

Animals↗