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Biomedical subjects

S Denny

Publications and source records attributed to S Denny.

8 recordsLinked to original sources

The contingency medical force: chronic challenge, new solution.

To keep pace with the changing requirements of the U.S. Army's combat doctrine, the U.S. Army Medical Department continually modifies its combat health support doctrine and unit organizations. This includes creating more capable, deployable, and mobile units. Unfortunately, as units become more capable, they become less mobile and deployable. As a result, striking a proper balance between capability, mobility, and deployability poses a significant challenge. In 1998, the 212th Mobile Army Surgical Hospital designed a rapidly deployable, air transportable medical module capable of supporting a brigade-sized contingency force (approximately 3,000 personnel) with level or echelon I to III medical care in an austere and ambiguous environment. This module, known as the contingency medical force (CMF), also provides command and control capabilities for this initial medical force and the transition to a more robust health care structure. Conducted over an 8-month period, the design process began with a staff exercise using the deliberate planning process model and culminated in a validation exercise monitored by external observers/controllers at the Combat Maneuver Training Center in Germany. This article describes the planning process, development, and initial deployment of the CMF. The CMF was then deployed on short notice to Albania in support of Task Force Hawk, the Army component of Joint Task Force Noble Anvil.

Germany↗

Structure, kinetics, and function of human and rhesus plasma prekallikreins are similar.

To determine if rhesus monkeys (Macaca mulatta) could serve as a model for studying the role of the contact system in the pathophysiology of human infections, we compared structural, kinetic, and functional characteristics of plasma prekallikrein and its activation products in rhesus and humans. Three prekallikrein variants (85-, 89- and 93-kDa) were revealed in rhesus plasma as compared with the two variants (85- and 88-kDa) in human plasma by immunoblotting with the monoclonal antibody MAb 13G11. The prekallikrein concentration in rhesus plasma was 1.5-fold that in human plasma as determined by computerized immunoblot analyses (CIBA) and amidolytic activity. The electrophoretic mobility of prekallikrein from plasma of both species increased after deglycosylation. Inhibition of prekallikrein activation by MAb 13G11 was 55% (rhesus plasma) and 76% (human plasma), with similar inhibition curves. Immunoblots of activated rhesus plasma showed prekallikrein, complexes of kallikrein with C1 inhibitor, alpha 2-macroglobulin and approximately 60-kDa inhibitor(s) (viz. antithrombin III), and 45-kDa fragments, like those in activated human plasma. Concentrations and molecular masses of factor XII and high molecular weight kininogen were similar in rhesus and human plasma. The activated partial thromboplastin time (APTT) and prothrombin time were 20.1 +/- 1.6 and 9.7 +/- 0.3 s for rhesus and 32.0 +/- 5.6 and 12 +/- 0.5 s for human plasma. Human and rhesus APTTs were similar when prekallikrein concentrations in human and rhesus plasma became alike by adding human purified prekallikrein.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗

The effect of disinfectants on a geosmin-producing strain of Streptomyces griseus.

This study describes the bactericidal and sporicidal effects of four disinfectants on a geosmin-producing strain of Streptomyces griseus. The disinfectants investigated were chlorine, chloramine, chlorine dioxide and ozone. Chlorine and chlorine dioxide at concentrations around 1 mg/l were effective inactivators of both spore and mycelial propagules. Decimation times of less than 1 min were determined in each case. Both growth forms exhibited a high ozone demand, but decimation times resulting from an initial dose of around 2.5 mg/l were approximately 1.5 min. Monochloramine was comparatively less effective: at a concentration of approximately 1 mg/l the decimation times for spores and mycelia were 13.8 and 22.7 min, respectively.

Chloramines↗

Ossification within the primate larynx.

Ossification of the laryngeal cartilages is a random occurrence possibly related to age and sex. A wide variety of primate larynges have been examined radiologically, by macroscopic section or after whole organ serial section with the aim of determining presence of ossification. The results of this investigation will be presented in an attempt to establish possible correlation between structure, function and degree of ossification within each specific larynx. This is a unique enquiry which may assist in the understanding of ossification within the human larynx.

Adult↗