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Biomedical subjects

S Di Filippo

Publications and source records attributed to S Di Filippo.

96 records · Page 6Linked to original sources
PubMedDate not supplied

[Doxorubicin in antiblastic hyperthermic perfusion in the treatment of advanced soft-tissue sarcoma of the limbs].

Different antineoplastic drugs have been associated to hyperthermia in the treatment of advanced soft tissue limb sarcoma with a good results in terms of conservative surgery (77%-97%), locoregional control (77%-87%) and overall survival (72%). Two different studies were performed: the first was carried out to analyze the doxorubicin-TNFalpha-hyperthermia association (three different trials) in terms of toxicity and efficacy of the treatment (tumor response, locoregional control, disease free and overall survival). The results showed that the trimodality association (doxorubicin TNFalpha and hyperthermia) is the best regimen able to obtain a 77% of objective response and 77% of limb sparing in patients candidate to amputation but may result in high local toxicity if high temperatures (>41.5 degrees C) were maintained during perfusion. The second study describes the employment of liposomal doxorubicin in hyperthermic antiblastic perfusion (HAP) in terms of tumor response, conservative surgery and toxicity; the maximum tolerable dose (MTD) of doxorubicin was 16 mg/l of perfused limb volume at the temperature of 41.5 degrees C; the conservative surgery was possible in 91% of the cases and mild (grade I and II) toxicity was observed in the perfused limb with high temperature (>41.5 degrees C).

Antibiotics, Antineoplastic↗
PubMedDate not supplied

120 peritoneal carcinomatoses from colorectal cancer treated with peritonectomy and intra-abdominal chemohyperthermia: a S.I.T.I.L.O. multicentric study.

A multicentric study has been carried out on 120 patients affected by peritoneal carcinomatosis from colorectal cancer. Patients have been treated by cytoreductive surgery and intra-operative hyperthermic chemoperfusion (HIPEC) with cisplatin (CDDP) and mitomycin-c (MMC). A small group of patients were treated with oxaliplatin (LOHP) following the Elias et al. scheme [intravenous 5-fluorouracil (400 mg/m2) and leucovorin (20 mg/m2) followed by intraperitoneal perfusion with LOHP (460 mg/m2) in 2 l/m2, during 30 min at 43 degrees C]. CC-0 cytoreduction was achieved in 85.2% of the patients. Major morbidity and mortality was 22.5% and 3.3%, respectively. No G4 toxicity was registered. The three-year survival was 25.8%. The difference in survival evaluating complete cytoreduction (CC-0) vs. incomplete (CC1-2; residual tumor nodules greater than 2.5 mm) was statistically significant (p < 0.0001). Evaluating only the patients that could be cytoreduced to CC-0, the 3-year survival was raised to 33.5%. In our experience the peritoneal cancer index (PCI) has been demonstrated to be a weak prognostic factor reaching a statistical significance only after the exclusion of patients with resected hepatic metastases. The patients treated with oxaliplatin were alive and free-of-disease after a 16-month median follow-up.

Adenocarcinoma↗
PubMedDate not supplied

Non-specific rhinoreactivity: non-specific nasal provocation tests with methacholine and cold water solution.

The Department of Allergo-Immunology of the II ENT Division of Rome University has studied the behaviour, relative to non-specific nasal provocation with methacholine and with cold water solution, in normal subjects, in subjects with seasonal allergic rhinitis in and out of crisis, and in subjects with perennial rhinitis of allergic and non-allergic origin. All subjects underwent an ENT visit, rhinoreomanometry (RRM), mucociliary Clearance (MCT) and quantitative evaluation of nasal secretion, both before and after the single non-specific provocations. We saw that even though provocation with methacholine didn't cause a significant reduction of nasal conductance, it was the cause of noticeable modifications of the amount of nasal secretion, according to the groups taken into consideration. Furthermore, provocation with the cold water solution, which didn't provoke noticeable changes in the mucociliary clearance and in the quantity of nasal secretion, did, however cause noticeable modification of the nasal conductance in all groups examined.

Adolescent↗