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Biomedical subjects

S Dluholucký

Publications and source records attributed to S Dluholucký.

At least 19 recordsLinked to original sources
PubMed1993

[Personal experience with the use of Rulid (roxithromycin) in children less than 1 year of age].

The authors give an account of the use of Roxithromycin (preparation Rulide) in children of the youngest age group, i.e. in infants. From January 1989 to April 1992 they treated 24 children under 5 weeks to 12 months of age with Roxithromycin. Roxithromycin was administered in amounts from 5 to 10 mg/kg after 12-hour intervals in the course of 4 to 12 days. In 22 children a favourable clinical effect was observed, in two children antibiotic treatment had to be changes because there was no clinical response. Undesirable effects, i.e. vomiting, during Roxithromycin were observed only in two children. In no instance was it necessary to discontinue treatment.

Bacterial Infections↗
PubMed1990

[Claforan in the treatment of serious infections in children].

To 63 critically sick patients on account of serious infection Claforan was administered. Forty-six patients were hospitalized at the intensive care and resuscitation unit and 17 patients suffered from oncological conditions. Claforan treatment was successful in 69.56% of the patients treated at the intensive care and resuscitation unit and in 30.44% in the group of oncological patients.

Acute Disease↗
PubMed1990

[Results of treatment of acute lymphoblastic leukemia over a 12-year period].

In the course of a 12-year period the authors treated at the Paediatric Department of the Regional Institute of National Health in Banská Bystrica 72 children with acute lymphoblastic leukaemia according to four protocols. Complete remission was achieved by 67 children, i.e. 93%. None of the children died from complications of treatment during complete remission. A relapse during treatment or soon after its termination occurred in 23 children, i.e. 31.9%. A second complete remission was achieved in 15 children, i.e. 65.2%. During the second complete remission seven children survive for 0.5-91.5 months. Twenty children died, i.e. 27.8%. All children had at the time of death signs of malignant disease. Fifty-two children survive at present for 1-132 months. The cumulative ratio of surviving children in the 12th year since the diagnosis is 0.57, the cumulative ratio of children in initial complete remission in the 12th year is 0.51.

Child↗
PubMed1990

[Hyperosmolar hyperglycemic coma in a 10-year-old patient].

A ten-year-old patient referred to a child ambulatory for preoperative examination suddenly falls unconscious. The physical finding and laboratory results suggest hyperosmolar hyperglycaemic coma. The authors describe the clinical course and therapeutic procedure. They draw attention to adequate fluid and ion repletion, to the importance of their balancing and to possible complications of treatment.

Child↗
PubMed1989

Studies on congenital hypothyroidism and results of three and half years of compulsory screening program in Slovak Socialist Republic.

In the introduction the results of previous retrospective study (1975-79) including 312,259 newborns and of preliminary screening program including 31,780 newborns are briefly summarized. After January 1st, 1985 a compulsory screening of congenital hypothyroidism (CH) was started in the whole territory of Slovakia using the estimation of thyroxine in dry blood spot obtained from a heel prick on 5th day after birth. In suspected cases a complete clinical and laboratory examination was made including TSH estimation by RIA and after January 1st, 1988 by IRMA. The organization of screening program is described in detail. During three and half year period 286,469 newborns were examined which represented almost 100 percent of all newborns. A total of 44 cases of CH was found out of them 13 cases of athyreosis, 3 cases of ectopic thyroid and 28 cases of dyshormonogenesis (among them 5 cases with goiter and 23 cases without goiter). The average incidence of CH was 1:6874. Until January 1st, 1988 (when only T4 estimation was used as a first step) the recall rate was 2.32% and the treatment was started before 25th day after birth, while after the use of TSH by IRMA from dry blood spot in suspected cases (i.e. after January 1st, 1988) the recall rate decreased to 0.82% and the treatment was started before 14th day of life. In addition, the data on 39 cases of TBG deficiency and on regional differences in their incidence are reported. Some remarkable differences in the incidence of total CH and of its individual variants between West, Central and East Slovakia with different historical, cultural, economical and genetical background as well as in some ethnic groups (Gypsies) are also presented.

Congenital Hypothyroidism↗