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Biomedical subjects

S Dobrzanski

Publications and source records attributed to S Dobrzanski.

10 recordsLinked to original sources

The impact of guidelines on peri-operative antibiotic administration.

A survey has shown that peri-operative antibiotic therapy was inappropriate in 83% of patients undergoing abdominal or arterial surgery. Missed doses at induction or postoperatively, a questionable choice of antibiotics and unnecessarily long postoperative courses were major problems. The introduction of formal guidelines was partially successful with appropriate prescribing improving from 17 to 60% of cases. There was, in addition, a marked reduction in prescribing costs.

Anti-Bacterial Agents

Granuflex dressings in treatment of full thickness pressure sores.

Granuflex Paste and Granuflex E extend the range of indications for using Granuflex products in pressure sore therapy. These dressings enable ulcers of any degree of severity to be treated, although they perform better on sores on limbs than on sacral sores.

Bandages, Hydrocolloid

Shaping a formulary.

Explore the source record for details and available documents.

Formularies as Topic

Use of a warfarin dose prediction method.

Warfarin dose prediction methods developed in one hospital might not be valid elsewhere. Factors such as heparin co-administration, the use of various thromboplastin reagents and differences in technique in the haematology laboratory should all be considered before a warfarin dose prediction method is accepted for use in a hospital.

Dose-Response Relationship, Drug

The effect of propranolol phentolamine and pimozide on drug-induced anorexia in the mouse.

Pimozide was a potent antagonist of (+)amphetamine, diethylpropion, mazindol and phentermine anorexia in the mouse. Phentolamine and propranolol produced no such antagonism, but either potentiated or had no effect on the drug-induced anorexia. Although the mechanism of action of the four anorectic agents appears to involve dopamine receptor agonist activity, an antagonist or partial agonist effect at noradrenergic receptors may also be involved.

Animals

The effects of (+)-amphetamine and fenfluramine on feeding in starved and satiated mice.

(+)-Amphetamine and fenfluramine depressed both the food intake during the first 2 h of feeding of mice adapted to feed between 12:00 and 15:00 daily and the food intake of free feeding mice between 24:00 and 02:00 (lighting on, 09:00-21:00) in a dose-dependent manner. Higher doses of each drug were needed to produce a significant depression in the latter case. However, (+)-amphetamine (0.5-2 mg/kg) markedly increased the negligible food intake of free feeding mice between 12:00 and 14:00, an effect which rapidly disappeared at higher doses. Fenfluramine at doses up to 40 mg/kg had no effect on the feeding of these mice. Nevertheless, as caffeine (10-40 mg/kg) also increased feeding, behavioural arousal might be an important factor in this anomalous feeding response, although a specific action by (+)-amphetamine and caffeine on the feeding centres of the satiated mouse cannot be ruled out.

Amphetamine

Pressure sores. Epidemiology and current management concepts.

Pressure sores remain common, with a prevalence of 5 to 9% and more than 70% occurring in patients over 70 years of age. They are often falsely ascribed to poor nursing care, but can more usefully be regarded as a potentially preventable complication of an acute immobility illness. Prevention involves identification of patients at risk, appropriate nursing care measures and the use of special equipment. Much of the special equipment is excessively complex and not validated by clinical trial work. The airwave system, polystyrene bead bed system and Vaperm mattress have been best studied and are effective. Management of the established sore involves treatment of the underlying medical condition(s), attention to hydration and nutrition, prevention of further tissue trauma and the use of special dressings and procedures which facilitate the inflammatory repair response. There is considerable doubt about the use of 'traditional' wound applications such as gauze or chlorinated lime and boric acid solution ('Eusol'). An extensive range of newer products is now available but these have not yet been subjected to controlled clinical trials. A useful starting point is to classify pressure sores into 4 clinical types depending on amount of tissue damage and depth of ulcer. The least severe sore (type 1) can be protected using polyurethane film dressings. Deeper ulcers (types 2 and 3) can be easily and quickly treated by hydrocolloid or alginate dressings which optimise the local wound environment, thus facilitating tissue repair. However, there may be no satisfactory dressing for sacral (near-anal) sores which are more difficult to treat than those at other body sites because of dressing detachment. Cavity ulcers (type 4) can be managed with silastic foam or hydrocolloid or alginate dressings. Debridement of necrotic material is best done manually by scalpel/scissors, although streptokinase/streptodornase (Varidase Topical) may also help if used correctly. Antiseptics have little part to play and ulcers are best cleaned with warm normal saline. Systemic antibiotics are indicated only when surrounding cellulitis is present, although metronidazole is useful for malodorous sores.

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