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Biomedical subjects

S Dorph

Publications and source records attributed to S Dorph.

At least 55 records · Page 3Linked to original sources
PubMed1980

Renovascular hypertension treated by autotransplantation.

Renal autotransplantation was performed in 16 patients with severe renovascular hypertension. The hypertension was cured in 13 patients, 2 patients were improved and one patient had no benefit. The postoperative function and morphology of the transplanted kidneys remained unchanged. In our view, renal autotransplantation is a valuable method in the surgical treatment of renovascular hypertension.

Adult↗
PubMed1979

Kidney distension during IV urography in normal rats and in rats with artificial unilateral renal artery stenosis.

Acute changes in kidney size during IV urography were studied in normal rats and in rats with artificial unilateral renal artery stenosis. In normal rats, IV bolus injection of sodium iothalamate (400 mg I/ml), 1.5 ml/kg body weight, produced an increase in area of the renal silhouette by an average maximum of 12.7% after 60 seconds. In nine out of ten rats which developed hypertension after left sided renal artery clamping, renal distension was either small or absent on the stenosed side, while the contralateral right kidney showed normal distension during IV urography. Two out of three rats, which remained normotensive after renal arterial clamping, showed normal distension of both kidneys. These results confirm earlier observations in man that the acute changes in size of the kidney during IV urography can be used as an aid in the urographic screening of hypertensive patients for significant renal arterial stenosis. In all rats with arterial clamp and hypertension, the stenosed kidney was smaller than its contralateral mate. An index between the size of the non-stenosed and the stenosed kidneys greater than 1.15 was only seen in these particular rats.

Animals↗
PubMed1978

Pyelorenal backflow during retrograde pyelography after renal transplantation.

Retrograde pyelography in 140 transplanted kidneys within 3 days of the operation showed a high frequency (29%) of pyelorenal backflow. Pyelotubular backflow, ordinarily a rare form of backflow, was seen in one-third of the patients whose transplants were removed within 60 days because of rejection, but in only 4% of the patients with surviving grafts. Pyelosinus backflow was found in 61% of the patients with signs of urinary obstruction, but in only 9% of the other patients. No relationship was found between pyelosinus backflow and graft rejection, or between pyelotubular backflow and urinary obstruction. Pyelotubular backflow may be an early radiographic sign of impending and serious rejection.

Cadaver↗
PubMed1977

The prognosis in Ebstein's disease of the heart. Long-term follow-up of 22 patients.

A follow-up study of 22 patients with Ebstein's anomaly has been performed. Nine patients died 1-21 years (mean 9) after the initial admission while the 13 patients alive at the end of the observation period had been followed for 5-26 years (mean 15). Clinical, ECG, radiological, and haemodynamic features were analyzed with reference to their prognostic significance. The presence or absence of cyanosis due to right-to-left shunt through an atrial septal defect (ASD) distinguished best between a good and poor prognosis. Right-sided heart failure and dyspnoea at rest, often associated with palpitations, precordial pains and syncopes, were grave prognostic findings. After the initial signs of heart failure there was a rapid deterioration, death ensuing within a few years. Operation with insertion of a prosthetic valve (and closure of the ASD) should be seriously considered at the appearance of heart failure.

Adolescent↗
PubMed1976

Predictive value of renography and i.v. urography for the outcome of reconstructive surgery in patients with hydronephrosis.

Intravenous urography and isotope renography studies were made in 54 patients with hydronephrosis. Thirty six of these patients underwent reconstructive surgery and were also studied postoperatively. Both studies gave more or less consistent results - that is to say evaluations of renal function and drainage from each individual study were similar - but no individual parameter was of any specific significance in the selection of patients for therapy. Points were allocated to each parameter, and after summing these points for each individual patient, 3 groupings became apparent: a low count group - patients with pelvectasia but normal renal function:a middle count group - patients with certain hydronephrosis; and a high count group with severe hydronephrosis, and markedly impaired renal function. Post-operatively, renal function was unaltered or mildly reduced in group 1, and improved in groups 2 and 3, though the differences were not statistically significant. It was hoped that the studied would allow differentiation between patients of the low count group, but the conundrum remains - which of them can be categorized as normal variants, and which were in fact displaying early pathological signs of essentially progressive disease.

Adolescent↗
PubMed1975

The narrow vestibular aquaeduct. An unspecific radiological sign?

Tomography of the vestibular aquaeduct was carried out in patients with Ménière's disease, patients with chronic otitis and in patients without ear disorders. Visualization of the vestibular aquaeduct was evaluated blindly. The descending part of the aquaeduct was clearly visible in 95% of patients without ear disease. In the other groups, including contralateral non-affected ears in Ménière patients, the aquaeduct was clearly visible in only about 50%. The incidence of narrow or invisible aquaeducts in ducts in Ménière patients and in patients with chronic otitis was essentially the same. This radiologic finding seems to be an unspecific sign, present possibly in a variety of ear disorders.

Adolescent↗
PubMed1975

Renal distension in response to water-soluble contrast medium and various diuretics.

Measurement of the increase in area of the renal silhouette, as it appears on radiographs following the administration of water-soluble contrast medium and certain diuretics, seems to be useful in the diagnosis of renovascular hypertension. In order to assess the optimal technique for such measurements, washout urography was performed in 32 hypertensive patients in two consecutive examinations so that the distensive effect of etacrynic acid, furosemide and hypertonic mannitol, respectively, were compared with that of urea in the same patients. In spite of their stronger diuretic effect, none of the above-mentioned diuretics caused a greater renal distension than urea, the maximum increase in area of the renal silhouette being about 7 to 20%, average about 11%. Since urea is probably the best siuted diuretic for the washout test, it seems to be the drug of choice for these diagnostic procedures.

Adult↗
PubMed1975

The effect of cholecystokinin on electrical spike potentials and intraluminal pressure variations in the human small intestine.

Electrical spike potentials and intrauminal pressure variations were recorded from the human duodenum and distal ileum before and after i.v. administration of 80 log Ivy units of cholecystokinin. In the duodenum, quantitative calculations of motility gave identical values before and after drug administration, and results were identical in patients before and after cholecystectomy as well as in hernia patients without upper gastrointestinal disease. A decrease in amplitude of the spike potentials was observed in the duodenum during the first few minutes after drug administration in all groups. Recordings from the distal ileum in ileostomy patients showed a significant increase in motility after CCK administration whereas the spike potential amplitude was unchanged.

Action Potentials↗