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Biomedical subjects

S Downs

Publications and source records attributed to S Downs.

9 recordsLinked to original sources
PubMed1994

Ethical issues in bone marrow transplantation.

Ethical issues in health care arise from the perspectives of individual rights and clinical research. The advances in technologies for the treatment of cancer that come from clinical research have created new ethical issues. Bone marrow transplantation is such a case where research has the potential to benefit, but our resources to provide this lifesaving option are scarce. Ethical issues that nurses face in BMT include informed consent, concerns about the rights of donors, and the allocation of resources.

Adult↗
PubMed1992

Bone marrow transplantation.

BMT is an effective treatment for certain malignant and nonmalignant conditions. The source of the marrow is autologous or allogeneic. An allogeneic donor can be an HLA-matched related or unrelated donor. The patient undergoes intense chemoradiotherapy to remove remaining malignant cells and obliterate the immune system, thus allowing growth of the new bone marrow cells. Complications of conditioning therapy include pancytopenia and distinct organ toxicities. Astute nursing care is critical in managing the care of BMT patients. Assessment and numerous, interrelated interventions are required. Late complications of BMT relate to the conditioning therapy and to the transplant itself. As BMT becomes more readily available as a treatment, economic issues related to the cost of care and the allocation of resources challenge health care providers.

Bone Marrow Transplantation↗
PubMed1976

Stromal sodium binding after glycosaminoglycan digestion.

The glycosaminoglycans of isolated rabbit corneal stroma, clamped between two lucite plates at near normal hydration, were digested with testicular hyaluronidase in saline solution. After equilibration with 0.9 per cent saline solution alone the sodium and chloride content of the stroma was determined. Chloride was in equilibrium with both normal and hyaluronidase-treated stroma, allowing use of the Donnan calculation for excess or bound sodium to be made. Normal stromas contained 200 mEq. bound sodium per kilogram of dry weight calculated from the Donnan calculation; hyaluronidase-treated stromas contained 110 mEq. bound sodium per kilogram of dry weight. The data show that about half of the bound sodium in the corneal stroma is on nonsaccharide binding sites. Quantitative verification of the loss of glycosaminoglycans was performed.

Animals↗