Biomedical subjects
Publications and source records attributed to S Dreborg.
Following renal transplantation, hepatic glucocerebroside deposits in a child with Gaucher disease were reduced. This suggests that enzyme replacement had been achieved.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
In 20 patients with Gaucher disease type III (Norrbottnian variant), long-term intellectual prognoses were analyzed on the basis of psychometric tests which were performed on an average of five tests per patient. Intellectual delay was not found to be characteristic of the early stages of the disease. Slow regression occurred through childhood and adolescence. Patients splenectomized at an early stage averaged lower IQ scores in the long-term than those in whom the spleen had been spared as long as possible. These data added to other evidence of increased neurologic and other organ impairment after splenectomy, support the view that the spleen should not be removed in other than emergent situations.
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Skin tests have for many years been widely used in the diagnosis of allergic diseases. Standardized allergic tests are commonly available for the diagnosis of inhalant allergy. However food allergens have been studied and no standardized preparations are available. Methods for skin testing vary between regions. In North America, the intradermal skin-test method dominates. On the other hand, pediatricians and Europeans favor the use of skin-prick test, as it is less painful and gives the same information as the intradermal method. Methods for interpretation also vary between regions and groups of doctors. Furthermore, criteria for disease (i.e., presence of food allergy) also varies. Because of the lack of standardized allergen techniques and method, there are difficulties in understanding and using the new data presented in scientific journals. In this article I discuss these difficulties and propose how to handle these problems, concentrating on the skin-prick test method.
To investigate the biological activity of P. judaica and P. officinalis allergen preparations, 36 Spanish patients were included in a biological standardization (BS) trial. For both species the concentration corresponding to 1000 biological units/ml (BU/ml) was found to be about 2 micrograms dry weight/ml (d.w./ml). The allergenic activity per microgram d.w. was about the same as reported for other important weed pollen extracts. The physico-chemical and immunological properties of the purified Parietaria judaica and Parietaria officinalis pollen allergen preparations used for biological standardization were investigated. The protein content was determined to 38% and 23% for P. judaica and P. officinalis respectively, while the carbohydrate content was 25% in both weed preparations. More than 40 antigens and at least 10 different allergens were detected by crossed immuno electrophoresis/crossed radio immunoelectrophoresis (CIE/CRIE) analyses. SDS-gPAGE followed by electroblotting showed important allergens between 10,000 and 75,000 d for both species. The crossreactivity as measured by skin prick test, RAST and CRIE was high.