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Biomedical subjects

S Driver

Publications and source records attributed to S Driver.

4 recordsLinked to original sources
PubMed2005

Social support and the physical activity behaviours of people with a brain injury.

PRIMARY OBJECTIVE: To examine the influence of social support on the physical activity behaviours of individual's with a traumatic brain injury. MAIN OUTCOMES AND RESULTS: The paper defines social support as a multi-dimensional construct and reviews relevant literature describing how the type and source of social support changes post-brain injury. These findings are then applied to a physical activity domain with the use of a conceptual framework. Discussion finally focuses on research applications and appropriate measures of social support within a physical activity environment. CONCLUSIONS: This paper will provide physical activity programmers with an understanding of how social support influences physical activity participation, a conceptual framework to guide programming and appropriate measures of social support for research purposes.

Adolescent↗
PubMed1999

Regulation of vascular endothelial growth factor-dependent retinal neovascularization by insulin-like growth factor-1 receptor.

Although insulin-like growth factor 1 (IGF-1) has been associated with retinopathy, proof of a direct relationship has been lacking. Here we show that an IGF-1 receptor antagonist suppresses retinal neovascularization in vivo, and infer that interactions between IGF-1 and the IGF-1 receptor are necessary for induction of maximal neovascularization by vascular endothelial growth factor (VEGF). IGF-1 receptor regulation of VEGF action is mediated at least in part through control of VEGF activation of p44/42 mitogen-activated protein kinase, establishing a hierarchical relationship between IGF-1 and VEGF receptors. These findings establish an essential role for IGF-1 in angiogenesis and demonstrate a new target for control of retinopathy. They also explain why diabetic retinopathy initially increases with the onset of insulin treatment. IGF-1 levels, low in untreated diabetes, rise with insulin therapy, permitting VEGF-induced retinopathy.

Animals↗