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Biomedical subjects

S Duţu

Publications and source records attributed to S Duţu.

At least 19 recordsLinked to original sources
PubMed1991

[The value of the spirographic examination in the follow-up with time of the lung functional states in children with bronchial asthma].

28 Children with bronchial asthma, aged 6-18 years, were followed up for varying time intervals, between 3 months and over 5 years. In the cases studied, 7-8 functional tests were used under different clinical conditions: asymptomatic, manifested clinical form of the bronchial asthma, crisis of expiratory dyspnea in various severeness degrees. For an easy use of the method in the pediatric network, the lung functional investigation consisted only of spirographic examination (CV (vital capacity), VEMS (max. expir. ventilation per second) VEMS/CV ratio). The study has to show which of the lung functional parameters, measured on the maximum and forced spirogram, are the most useful for the best evaluation of the functional state of the asthmatic child. The VEMS value proved to be the most correct one for appreciating the presence and severeness degree of the obstructive syndrome The slight variation of the VEMS/CV ratio showed that the information given by this parameter cannot reveal enough the alteration of the lung function in child. For a better evaluation of the lung functional state in the asthmatic child, the routine spirographic examination, has to be completed with more "sensible" tests, such as FEF25-755 and MEF59 and with other functional parameters measured by plethysmographic examination (VGT, Raw).

Adolescent↗
PubMed1980

[Epidemiological study of chronic bronchitis in a population sample aged 60-85 years: contributions to the study of the natural history of chronic bronchitis (author's transl)].

An epidemiological study was undertaken by means of the MRC questionnaire on respiratory symptoms and of spirographic tests (VC and FEV 1.0) in a population of elderly people (374 men and 377 women 60-85 years old) examined periodically during the last 10 years. In a large number (39,2%) of smokers who had persistent cough the spirographic values were normal. (The reference values for VC and FEV 1.0 were obtained by means of regression equations developed from samples of subjects belonging to the same age-group who had no history or symptoms of respiratory disease).

Aged↗
PubMedDate not supplied

[Pulmonary involvement in scleroderma].

The paper deals with 3 cases of sclerodermia with pulmonary determinations detected by clinical, radiological, functional and histopathological means, of diffuse interstitial fibrosis type. The association with bronchopulmonary cancer is pointed out in one case only.

Adenocarcinoma↗
PubMedDate not supplied

Clinical management of bronchial asthma with inhaled high-dose beclomethasone dipropionate (Beclomet 250--Orion).

The efficacy of inhaled high-dose beclomethasone dipropionate (BDP) in intrinsic and cortico-dependent asthma was studied in 12 asthmatics (3 males and 9 females), average age 39 years (range 17-62 years), with a mean duration of the disease of 9 years (range 2-20 years). The patients were instructed to use one actuation (250 micrograms), three times daily or two actuations three times daily in severe cases in which dyspnoea persisted during the intake of oral corticosteroids. The results during the 6 month follow-up period were: Clinical: dyspnoea, wheeze and cough disappeared or diminished, oral administration of corticosteroids stopped or the daily dose was reduced, the intake of beta-agonists decreased; Functional: after 2-4 weeks, in almost all cases, the base line values of FEV 1.0 and Raw were normal and hyperinflation significantly diminished after the first month of BDP therapy. Clinical and functional improvement were maintained during the follow-up period; no side-effects were revealed.

Administration, Inhalation↗
PubMedDate not supplied

[Obstructive syndrome in laryngotracheal stenosis].

Pulmonary function studies were carried out in 13 patients in whom the diagnosis of a central (laryngeal or tracheal) stenosis was confirmed by endoscopy. Following lung function tests were performed: static lung volumes (VC, RV, TLC), FEV1.0 and FIV1.0, flow-volume loops of forced expiratory and forced inspiratory vital capacity efforts from which PEFR and PIFR, maximal expiratory (VEmx50) and maximal inspiratory flow at 50 per cent of vital capacity (VLmx50) were measured, Raw, helium mixing time and pharmacological test with acethylcholine. FIV1.0 values and flow-volume loops permitted the classification of the patients into 3 groups: 1. fixed obstruction (6 cases): decrease in about equal proportions of maximal expiratory and inspiratory flows (FEV1.0 and FIV1.0); normal FEV1.0/FIV1.0 ratio; 2. extrathoracic variable obstruction (1 case): predominant decrease in maximal inspiratory flows (FIV1.0). FEV1.0/FIV1.0 ratio is twice as normal; 3. intrathoracic variable obstruction (5 cases): exclusive or predominant reduction in maximal expiratory flows, as in COPD but with the difference that the expiratory limb of the V:V loop showed an excessive reduction in PEFR, a plateau in the midzone of the VC and a terminal portion with normal configuration. Raw was almost always increased, RV sometimes, helium mixing time was prolonged only in presence of COPD or lobar stenosis; pharmacological tests were negative in 3 out of 4 cases. Pulmonary function abnormalities did not allow a prognosis of the nature of the underlying lesion. The severity of the obstruction as evaluated by endoscopic examination was not related to the functional disturbances. In one case no functional alterations were found despite a severe tracheal stenosis.

Adult↗
PubMedDate not supplied

[Prevalence of chronic productive cough and obstructive ventilatory dysfunction in a rural community with minimal air pollution].

Results obtained during an epidemiological investigation on chronic cough and obstructive ventilatory dysfunction in subjects without bronchopulmonary affections of known etiopathogeny, carried out in a rural environment with minimal air pollution on 282 men aged between 40 and 69 years, indicate the following: --there was a lower prevalence of chronic cough in the rural environment as compared with the urban one (12.8:21.0). The percentage of heavy smokers being approximately similar in both environments, the difference could be explained by the variable intensity of air pollution, the impact of which was exerted on the large airways (hypertrophy of the serous-mucous glands resulting in hypercrinia with dyscrinia); --similar prevalence in the two environments of the obstructive ventilatory dysfunction (11,0:8,7) suggests that this abnormality, an expression of the narrowing of the small airways, could be due to other pathogenic factors. Functional pulmonary tests with sensitivity higher than the ratio between FEV 1.0 and VC (as, for instance VEmx 50% VC) could provide higher percentages of obstructive disturbances both among chronic coughing and non-coughing subjects, revealing the latent form of the obstruction, as opposed to the manifest one as evidenced by a decrease of the FEV 1.0/VC ratio.

Adult↗
PubMedDate not supplied

[Epidemiological study of chronic cough and obstructive ventilatory dysfunction in a rural area].

An epidemiological study (MRC--Questionnaire and spirography) has been carried out on a population aged between 40 and 69 years living in a rural area (Costeşti, district of Buzău). 440 subjects (202 men and 238 women; 83% of the population in this age group) were examined. Chronic productive cough in subjects with no other respiratory diseases was found in 8,9% of the examinated males and in 5.0% of the females. The figures are lower than those found in an urban population and in a previous survey in an other rural area. Obstructive syndrome (reduced FEV 1.0/VC ratio) was found in 5.0 and in 2.9%, respectively. More than half of the patients with obstructive syndrome had no cough; the lung function alterations found in these subjects may be due--at least in some cases--to the obstruction of distal airways which have no clinical manifestations in the early stages.

Adult↗
PubMedDate not supplied

[The time variations in pulmonary functional parameters in children with bronchial asthma].

28 children with bronchial asthma, between 6 and 18 years old, were followed by a varied period of time - 3 months - 5 years. 7-8 functional tests were carried out. The cases were studied in different clinical phases: asymptomatic, manifest, crisis of bronchial asthma. The functional pulmonary investigation included: spirographic examination [vital capacity (VC), maximum expiratory volume per second (MEVS) the VC/MEVS ratio], plethysmographic examination (VGT, Raw), measurement of the maximum instantaneous expiratory flows on the flux-volume curve (MEF50). The average value, standard residual deviation and the variation coefficient were calculated for each parameter studied in different clinical moments. The results are presented on 3 groups: per total, symptomatic and asymptomatic. The analysis of the data found showed that the variation of the parameters measured during repeated functional examinations in children with bronchial asthma ranges within broad limits (2.9%-11.5%); the broadest variation was recorded for Raw followed by MEF50 and the slightest variation was that of the VC/MEVS ratio. This indicated the lower value of the information furnished by this ratio in children, in appreciating the presence or severeness degree of the obstructive syndrome.

Adolescent↗
PubMedDate not supplied

[Disodium cromoglycate treatment of bronchial asthma and spastic bronchitis (preliminiary results)].

After a short review of the mode of action of sodium chromoglycate, the results are presented, of the treatment carried out over a three months period in a group of 31 patients of which 23 had bronchial asthma and 8 had spastic bronchitis. In 19 cases the doses of steroids that the patients were receiving were either diminished or supressed, in 14 cases the doses of broncho-dilating drugs were diminished or supressed and in 15 cases the results of the respiratory function tests were improved or much improved. A synthetic evaluation of the clinical and laboratory results showed that in 3/4 of the cases (74.2%) these were either favourable or very favourable. The treatment was well tolerated and no side-effects were noted.

Adult↗
PubMedDate not supplied

Pulmonary mechanics in patients with diffuse interstitial lung disease and normal lung volume.

Static expiratory pressure-volume curves obtained in 20 patients with diffuse interstitial lung disease and lung volume within normal ranges (i.e. in patients in an early stage of the disease) showed different patterns of abnormal lung elastic recoil: 1) P-V curves with normal shape but shifted to the right, which suggest an overdistension of a reduced number of functioning alveoli ("lung shrinkage") and 2) flattened P-V curves (i.e. with low static compliance) also shifted to the right, which argue for an abnormal distensibility of most alveoli or a more diffuse spreading of lesions. These patterns suggest a multifactorial genesis of the increased elastic recoil in diffuse interstitial lung disease.

Adult↗