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Biomedical subjects

S Durán García

Publications and source records attributed to S Durán García.

At least 19 recordsLinked to original sources
PubMed2005

[Pioglitazone. Review of its metabolic and systemic effects].

Type 2 diabetes mellitus has become a true epidemic and significant growth is expected in the next decades. Thus it could be expected that the impact it may have on the incidence and prevalence of cardiovascular morbidity-mortality will have considerable magnitudes. It has been demonstrated that adequate metabolic control (glycemic and lipid) of these patients, beginning with diet and exercise programs and then with drug measures, decreases the risk of complications. However, several studies have shown that metabolic control deteriorates over time regardless of the treatment used. In recent years, a new drug family has been incorporated into the therapeutic armamentarium to treat type 2 diabetes mellitus. These are thiazolidinediones or glitazones, which have differential aspects regarding other drugs. In this article, the metabolic and systemic effects of pioglitazone, that have recently demonstrated a positive effect in the secondary prevention of cardiovascular episodes in the PROactive study have been reviewed.

Cardiovascular Diseases↗
PubMed1992

[A glucose tolerance study in the 12 months postpartum in patients with gestational diabetes].

BACKGROUND: It has been reported that patients with gestational diabetes have a considerable long term risk of developing diabetes mellitus. METHOD: Glucose tolerance was studied in the 12 months following birth in 155 patients diagnosed by the authors as having gestational diabetes and followed during pregnancy. RESULTS: It was observed that in 48% of the patients alterations persisted (33% glucose intolerance and 15% diabetes mellitus). Glucose tolerance during gestation and the perinatal results were retrospectively analyzed with a relation with the postpartum reclassification being observed. CONCLUSIONS: It was estimated that the percentage of alterations in glucose tolerance persisting postpartum is extremely high, suggesting the need for this test with a double objective: the reclassification of gestational diabetes and the early detection of glucose intolerance and diabetes mellitus.

Adult↗
PubMed1990

[The dawn phenomenon in diabetic pregnancy].

The possible development of the dawn phenomenon in three gestational stages was investigated in 9 pregnant women with type I diabetes mellitus and 10 with gestational diabetes. To this end, the overnight intravenous insulin infusion was evaluated with the artificial pancreas (Biostator). In none of the two clinical conditions and in none of the three gestational stages an increased insulin infusions during the second period of the night was found under the experimental conditions of our study. This finding may we related with the timing of the last food intake.

Adolescent↗
PubMed1989

[Evaluation of the insulin requirements with an artificial pancreas in gestational diabetes].

The evolution of insulin requirements in 10 patients with gestational diabetes mellitus was evaluated with the use of an artificial pancreas. We found that intravenous insulin requirements showed a definite tendency to decline, the greatest reduction being found between gestational weeks 27 and 37. Postprandial requirements after lunch were significantly higher in the weeks 15 and 27, with a tendency to become equal to those corresponding to breakfast and dinner in week 37. We found a lack of lineal correlation between the intravenous and subcutaneous requirements. We conclude that the artificial pancreas is a useful instrument to examine in detail the temporal evolution of insulin requirements in gestational diabetes. The artificial pancreas facilitates the adjustment of insulin therapy and plays a major role in the understanding of the pathophysiological abnormalities in these patients.

Adult↗
PubMed1989

[Evaluation of the insulin requirements with an artificial pancreas in the pregnant woman with gestational insulin-dependent diabetes (type I)].

The evolution of insulin requirements in 9 pregnant women with insulin-dependent diabetes mellitus (type I) was evaluated. Requirements were increased between weeks 11 and 24 and remained stable between weeks 24 and 35. Those corresponding to breakfast in the two initial connections were significantly higher, while those corresponding to breakfast, lunch and dinner became equal in the last connection (35 gestational weeks). We found a significant lineal correlation between the intravenous and the subcutaneous requirements. We conclude that the artificial pancreas is a useful instrument, which permits a detailed analysis of the time course of intravenous insulin requirements during pregnancy in the insulin-dependent pregnant woman and facilitates the adjustment of insulin therapy.

Adolescent↗