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Biomedical subjects

S E Borgesen

Publications and source records attributed to S E Borgesen.

8 recordsLinked to original sources
PubMed1977

Spinal tumours associated with increased intracranial pressure. Report of two cases and a discussion on the pathophysiology.

Two cases of increased intracranial pressure associated with lumbar intraspinal tumours are reported. On the basis of protein investigations and constant flow infusion manometric tests, the pathophysiology of the increased intracranial pressure is discussed. It is demonstrated that protein macromolecules leak from the tumour into the cerebrospinal fluid and suggested that these are responsible for mechanical obstruction of the outflow channels for the cerebrospinal fluid.

Adult↗
PubMed1976

Treatment of migraine with propranolol.

Thirty patients suffering from intractable, repetitive migraine took part in a double-blind single-crossover trial to compare the effect of propranolol (at 120 mg per day) with that of placebo. During propranolol treatment the frequency of migraine attacks was reduced significantly, by more that 50% in 9 patients and by less that 50% in a further 9. In the remainder propranlol showed no advantage over placebo. It is concluded that, as propranolol has only few and mild side effects, it is a useful drug for preventing migraine attacks. As the pathogenesis of migraine is not completely understood, the mode of action of propranolol in preventing attacks cannot be fully explained. It has been possible, however, to relate some of the effects of beta-receptor antagonism to current knowledge of the condition.

Clinical Trials as Topic↗