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Biomedical subjects

S E Efem

Publications and source records attributed to S E Efem.

14 recordsLinked to original sources

Clinical and bacteriological study on childhood empyema in south eastern Nigeria.

Forty-eight children with empyema thoracis were seen over a seven-year period (December, 1982 to November 1989) in the University of Calabar Teaching Hospital, Calabar, Nigeria. This number accounted for 0.2% of all paediatric admissions during the period. The peak age incidence was 2 years and under. Pneumonia was the antecedent illness in about all cases, but surprisingly, measles played an insignificant role. Late consultation and severe morbidity were constant feature with anaemia and cardiac failure as frequent complications of the disease. Staphylococcus aureus, the predominant causative organism was resistant to penicillin and ampicillin but sensitive to gentamicin, cloxacillin and erythromycin. The initial use of the parenteral gentamicin or cloxacillin in treating children with empyema is therefore recommended. This study demonstrates the rarity and low fatality (6%) of childhood empyema in Calabar, but protracted hospitalisation and exorbitant medication involved make it an important disease. Perhaps, it can be completely eliminated if parents are educated enough to avoid late reporting of childhood respiratory disease.

Adolescent

The effects of fresh palm wine on human gastric acid secretion.

The effect of fresh palm wine on gastric acid secretion was studied using human volunteers. Basal acid output for seven subjects used for the study with palm wine was 1.05 +/- 0.14 mMol/hr (mean and SEM). Peak acid output following the administration of 200 ml of the palm wine was 1.21 +/- 0.20 mMol/hr, and was not statistically different from the basal. Basal acid output for six subjects used for the study with ethanol (a constituent of palm wine) was 0.95 +/- 0.13 mMol/hr and following the administration of 200 ml of 5% ethanol the peak acid output was 5.85 +/- 0.32 mMol/hr. This peak acid output was higher in the ethanol group than the palm wine group (p less than 0.001). Fresh palm wine is not ulcerogenic as might be thought despite its content of ethyl alcohol (5%).

Adult

Clinical observations on the wound healing properties of honey.

Fifty-nine patients with wounds and ulcers most of which (80 per cent) had failed to heal with conventional treatment were treated with unprocessed honey. Fifty-eight cases showed remarkable improvement following topical application of honey. One case, later diagnosed as Buruli ulcer, failed to respond. Wounds that were sterile at the outset, remained sterile until healed, while infected wounds and ulcer became sterile within 1 week of topical application of honey. Honey debrided wounds rapidly, replacing sloughs with granulation tissue. It also promoted rapid epithelialization, and absorption of oedema from around the ulcer margins.

Administration, Topical

The antimicrobial spectrum of honey and its clinical significance.

The antimicrobial spectrum of honey was investigated by placing two drops into each of the wells made on culture media on which pure cultures of various organisms obtained from surgical specimens were grown. The organisms were grown under both aerobic and anaerobic environments. Fungal cultures of common fungi causing surgical infections or wound contaminations were mixed with 100%, 50% and 20% unprocessed honey. Growth inhibition was complete in the media containing 100%, partial in media containing 50% and no inhibition was produced by 20% honey. Unprocessed honey inhibited most of the fungi and bacteria causing wound infection and surgical infection except Pseudomonas aeruginosa and Clostridium oedematiens. Apart from Streptococcus pyogenes which is only moderately inhibited, golden syrup, a sugar syrup with similar physical properties as honey, did not inhibit any of the bacteria or fungi tested, demonstrating that honey is superior to any hypertonic sugar solution in antimicrobial activity. Honey is thus an ideal topical wound dressing agent in surgical infections, burns and wound infections.

Bacterial Infections