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Biomedical subjects

S E Hallgren

Publications and source records attributed to S E Hallgren.

5 recordsLinked to original sources
PubMed1991

Effects of verapamil and diltiazem on gastric emptying in normal subjects.

It has been suggested that calcium-channel blockers may delay gastric emptying by inhibiting gastric smooth muscle contraction. Most reports in man, however, reveal no significant delay in gastric emptying after using nifedipine; other calcium-channel blockers have not been studied in humans to date. We studied the effects of verapamil and diltiazem on solid-phase gastric emptying in 10 healthy volunteers. Each subject underwent a radionuclide gastric emptying determination (1) without preadministered medication, (2) after verapamil 80 mg orally every 6 hr for 10 doses, and (3) after diltiazem 60 mg by mouth given as one dose. Results revealed no significant difference in gastric emptying rates after pretreatment with verapamil or diltiazem when compared with no premedication (P greater than 0.37). We conclude that verapamil and diltiazem do not significantly delay gastric emptying in normal subjects. These data may be of clinical significance when prescribing calcium-channel blockers to patients with diseases associated with altered gastric emptying.

Adult↗
PubMed1989

Renal excretion of endoscopic retrograde cholangiopancreatography injected contrast. A common phenomenon.

The renal excretion of contrast injected during endoscopic retrograde cholangiopancreatography (ERCP) has been described as an uncommon event. Patients with this phenomenon have been considered at increased risk of acute pancreatitis, but idiosyncratic reactions from this intravascular contrast have been discounted as nonexistent. Thirteen patients underwent noncontrast abdominal computed tomography (CT) before ERCP and noncontrast CT plus abdominal radiography immediately after ERCP. Renal excretion of ERCP-injected contrast was seen in two patients on abdominal films and in nine patients by CT. All patients had normal renal function and none developed clinical pancreatitis. Renal excretion of ERCP-injected contrast is much more common than previously suspected. Iodine allergy and possible reaction should be considered when performing this procedure.

Adult↗
PubMed1987

Gallstones: a comparison of real-time ultrasonography and cholecystography with surgical correlation.

Real-time ultrasonography is more accurate and technically more efficient than gray scale ultrasonography in establishing the diagnosis of cholecystolithiasis. In prospective studies accuracy may be as high as 96%, and reflects the use of specific sonographic diagnostic criteria. Retrospective studies, however, reveal a lower accuracy rate of 90%, suggesting that practicing radiologists are not ready to accept these restricting criteria. On the other hand, oral cholecystography (OCG) is well tolerated and gives a reproducible, reliable result independent of technical expertise. It is 96% accurate in detecting the presence of gallstones and carries a sensitivity of .97. Both studies are prone to overinterpretation, which skews specificity and adversely affects diagnostic accuracy. In this retrospective review of 234 consecutive cases of cholecystectomy, real-time ultrasound was 90% accurate with a sensitivity of .96 in determining the presence of cholecystolithiasis. Oral cholecystography was 95% accurate with a sensitivity of .97.

Administration, Oral↗
PubMed1982

Bond strength of orthodontic direct-bonding cement-bracket systems as studied in vitro.

Tensile bond strength and failure location were evaluated in vitro for three types of direct bonding cements (unfilled, low filled, and highly filled) with three types of brackets (polycarbonate, stainless steel, and ceramic) using natural teeth and plastic as substrates. An unfilled acrylic cement gave the highest values of bond strength for both the plastic and ceramic brackets, whereas a highly-filled diacrylate cement gave the highest bond strength for the metal brackets. Bond failures occurred at the bracket-cement interface with the stainless steel brackets with each cement, whereas failure locations occurred at the bracket-cement interface, within the cement, and within the bracket for the plastic and ceramic brackets. There were no significant differences in bond strength nor failure location between tooth and plastic substrates.

Dental Bonding↗