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Biomedical subjects

S E Handfield-Jones

Publications and source records attributed to S E Handfield-Jones.

32 records · Page 2Linked to original sources
PubMed1992

Juvenile colloid milium: clinical, histological and ultrastructural features.

We report the clinical, histological and ultrastructural features of juvenile colloid milium affecting a brother and sister. In this rare condition, translucent papules develop on sun-exposed areas of skin, with onset in childhood. Histologically and ultrastructurally, the papules consist of amyloid-like material derived from epidermal keratonocytes. A review of the literature suggests a possible genetic abnormality that leads to sun-induced degeneration of keratinocytes.

Adolescent↗
PubMed1992

Acrokeratosis paraneoplastica of Bazex.

Bazex disease is one of the rarer cutaneous paraneoplastic syndromes. It is characterized by psoriasiform changes on the digits, and in some patients spread to the ears, nose and in later stages to the limbs and trunk. The associated malignancy is typically a squamous cell carcinoma of the upper aerodigestive tract. We review the literature regarding acrokeratosis paraneoplastica of Bazex and report three cases which illustrate both the typical and some of the less common changes that are seen in the condition.

Aged↗
PubMed1991

Vascular nevi.

Vascular nevi occur in up to 70% of infants. The term includes hemangiomas, of which the majority involute, and vascular malformations, such as port wine stains which tend to persist. The appearance, and in some cases rapid growth of the lesion, may be alarming to the parents and may cause great distress to the patient. In rare cases systemic involvement and associated abnormalities may be life threatening or permanently disabling. Correct diagnosis of the type of lesion is vital to know the prognosis of the lesion, the likelihood of complications and whether investigations and treatment are indicated.

Hemangioma↗
PubMed1989

Vulval lymphangiectasia.

Three cases of lymphangiectasia of the vulva are reported. One case followed Wertheim's hysterectomy for carcinoma of the cervix; two other cases had Crohn's disease with perineal involvement. Lymphangiectasia is a secondary phenomenon resulting from obstruction of previously normal lymphatics. This is in contrast with lymphangioma which is an anatomical abnormality. A review of the literature suggests that the vulval skin may be particularly susceptible to the formation of lymphangiectasia, and our patients' experiences suggest that they are easily mis-diagnosed.

Adult↗
PubMed1988

Comparison of a hydrocolloid dressing and paraffin gauze in the treatment of venous ulcers.

In-patients with venous leg ulcers showed increased healing rates with a hydrocolloid dressing (Granuflex), as compared with a traditional paraffin gauze dressing (Jelonet), in a randomized sequential crossover trial, although the difference was not statistically significant. Bacteriological studies showed that the hydrocolloid dressing favoured growth of both aerobes and anaerobes in significantly greater numbers compared with paraffin gauze. Heavy bacterial colonization had no effect on the healing rates of the ulcers. Granuflex is said to produce an anaerobic environment--survival of Pseudomonas aeruginosa, a strict aerobe, under Granuflex dressings, makes this seem unlikely.

Aged↗