PubMed Health⌕ Search

Biomedical subjects

S E Hovius

Publications and source records attributed to S E Hovius.

18 recordsLinked to original sources
PubMed1992

Acute effects of cigarette smoking on microcirculation of the thumb.

The acute effect of smoking on the microcirculation of the skin of the thumb was investigated in healthy volunteers. Twenty-two were smokers and 10 were non-smokers. The flow was assessed by means of laser Doppler flowmetry. The smokers inhaled 2 cigarettes. During smoking of their first and second cigarette respectively, a mean decrease in laser Doppler flow of 23.8% and 29.0% was seen (p = 0.03; p = 0.01). Ten minutes after smoking this decrease was recovered by half. This experiment confirms that one should prohibit smoking of cigarettes pre- and postoperatively for optimal wound healing conditions.

Adolescent↗
PubMed1992

Replantation of the radial side of the hand in the rhesus monkey: anatomical and functional aspects. A preliminary study to composite tissue allografting.

Before human hand transplantation can even be considered, an appropriate research model must be studied in a non-human primate. The first ray of the hand, augmented with a radial forearm flap, was chosen as a functional composite tissue graft. Four technically successful replantation of the radial unit have been carried out. One monkey died on the first post-operative day due to cardiac arrythmia. Normal wound healing occurred in the other three animals. In three monkeys, functional sensory and motor recovery was almost complete. The monkeys were able to pick up small particles of food with the index finger and thumb. It is suggested that this model could be used for allogeneic composite tissue transplantation in a non-human primate.

Animals↗
PubMed1992

The acute effect of cigarette smoking on the microcirculation of a replanted digit.

Thirty-one patients who had undergone digital replantation or revascularization volunteered to participate in a study of the acute effect of smoking on the microcirculation of the skin of replanted fingers. Fourteen were smokers and 17 were nonsmokers at the time of the study. Blood flow was assessed by means of the laser Doppler flowmeter under standard conditions. Each smoker inhaled 2 cigarettes. During smoking of the first and second cigarettes a mean decrease in laser Doppler flow of 8% and 19%, respectively, was found, whereas the nonsmokers showed a slight increase of 4% and 4%, respectively. Ten minutes after the last cigarette almost no recovery could be detected. The negative effect of smoking on the microcirculation in replanted digits proved to be more pronounced in the patients operated on more recently. This experiment confirms that smoking after replantation surgery should be prohibited to guarantee optimal circulation.

Adult↗
PubMed1992

Results of small-joint arthrodesis: comparison of Kirschner wire fixation with tension band wire technique.

In a retrospective study the results of 203 interphalangeal and metacarpophalangeal arthrodeses performed between 1977 and 1990 were reviewed. Eighty-three percent of the cases involved severe hand injuries. Two fixation techniques were used. During the early period, 143 arthrodeses were performed with percutaneous Kirschner wires, combined with either interosseous wiring or plaster of Paris. From 1987 to 1990, 60 arthrodeses were performed with the use of tension band fixation. In the Kirschner wire group 18% of the patients had pin-track infections, and in 15% rearthrodeses were necessary. In the tension band group 2% of the patients had an infection, and in 5% rearthrodeses were performed. Both the infection rate and the rearthrodeses rate were significantly lower in the tension band group than in the Kirschner wire group. Judging from this study, the tension band fixation technique is the method of choice for arthrodeses of the small finger joints.

Adolescent↗
PubMed1992

Allogeneic transplantation of the radial side of the hand in the rhesus monkey: I. Technical aspects.

Since allogeneic transplantation of extremities can only be considered if uneventful long-term survival and functional recovery can be achieved, a series of 12 transplantations of the radial side of the hand were performed in rhesus monkeys so that these factors could be assessed. The transplant incorporated the first ray of the hand in conjunction with the radial forearm flap. Graft survival times varied from 21 to 179 days. Ten of 12 transplants showed rejection. In 2 of the 10, rejection could be reversed. Immunosuppressive therapy consisted of cyclosporin A, prednisone, monoclonal antibodies, and preoperative third-party blood transfusions. Monitoring of the microcirculation of the allograft could not provide a predictive value for transplant rejection. The first clinical signs of sensory and motor function recovery were detected after an average of 42 and 44 days, respectively. Indefinite uneventful allograft survival could not be established. Major complications such as sepsis, shock, and lymphoma development leading to death were encountered. The model, however, is technically feasible, and the results for functional recovery under immunosuppression are promising.

Animals↗
PubMed1991

Acute management of traumatic forequarter amputations: case reports.

Traumatic forequarter amputation is a rare and very devastating injury. The arm, including the scapula, clavicle, and pectoral muscle, is torn from the body by a tremendous traction force, usually combined with a counteracting force from the body. The cases of three patients are presented. One patient was caught by the axle of a harvesting machine, resulting in a forequarter amputation of his right extremity and amputation of his left arm at the level of the upper arm. The other two patients had their arms caught in conveyer belts. All patients survived. Closure of the defect was performed acutely using a local pedicled musculocutaneous flap in one case and free vascularized musculocutaneous flaps from the amputated limbs in the two other cases.

Accidents, Occupational↗
PubMed1991

A protective thermoplast splint for the forearm and hand in nonhuman primates.

A custom-made thermoplastic splint was developed for the protection of the upper extremity after experimental surgery. It was used in 39 cases for a duration of 12-79 days. Complications were minimal and transient. The cast was easy to make, in one piece and inexpensive. Frequent removal for wound inspection was simple. This splint provides a good immobilization and protection of the arm and hand in the nonhuman primate.

Animals↗
PubMed1989

Results of treatment of 48 ring avulsion injuries.

A retrospective study of 48 patients with ring avulsion injuries was performed. Patients were grouped according to severity of damage. Revascularization with interposition grafts was performed in all patients where indicated. In contrast to the experience of others, even class III lesions (total avulsion) were salvaged.

Finger Injuries↗
PubMed1988

Experiences with the lateral calcaneal artery flap.

A chronic ulcer of the posterior heel or lateral ankle can be a large problem for the patient. The lateral calcaneal artery flap is a reliable neurovascular local skin flap that can cover the defect after excision of the ulcer in this area. The flap includes the lateral calcaneal artery, sural nerve, and lesser saphenous vein. We performed seven lateral calcaneal artery flaps from 1974 to 1986 for chronic ulcers of the heel or lateral malleolus. None failed. All patients can wear closed shoes. Two donor sites showed secondary healing. One donor site showed hyperkeratosis resulting from inappropriate planning of the flap.

Adult↗
PubMed1988

Postoperative monitoring of allogeneic limb transplantation in rats.

Allogeneic limb transplantation with and without immunosuppression has been successfully reported. We used the experimental model described by Fritz and colleagues to investigate the value of different factors in the rejection phase. Twenty rats of inbred strains sustained an allogeneic limb transplantation without immunosuppression. In 6 rats an isologous limb transplantation was performed as a control group. Factors investigated in the transplanted limb were glucose, lactic acid, and blood gases of the peripheral blood, as well as laser Doppler flowmeter (LDF) recordings and histology. All factors were compared with the normal contralateral limb of the rat. All rats were killed between days 2 to 14 following operation. In the allogeneic limb transplantation model in the rat, clinical and histological examination as well as LDF measurements (p less than 0.0001) are good factors for rejection. In contrast, peripheral blood gases, glucose, and lactate were not useful as factors for rejection. In this model, however, LDF values cannot predict an initial onset of the rejection before clinical signs are evident, presumably because of the impossibility of continuous measurements.

Animals↗
PubMed1988

The radial forearm flap.

The radial forearm flap or 'Chinese' flap, originally used as a fasciocutaneous flap based on the radial artery, is extremely versatile and can be employed as free vascularized or island flap with or without skin, vascularized nerve, tendons or bone. The radial forearm flap was performed in 21 patients (16 free and 5 as a distally based island flap) for head and neck as well as for hand and foot reconstruction. All flaps survived. Indications and complications are discussed.

Adolescent↗
PubMedDate not supplied

Degloving injuries. A retrospective study at the University Hospital Rotterdam.

Degloving injuries are severe and frequently underestimated lesions. In a retrospective study, 65 patients treated between 1985 and 1991 were reviewed. Therapy consisted of surgical exploration as soon after injury as possible, with defatting of the avulsed skin and its replacement on the most functionally important sites. The remaining raw areas were covered with split skin grafts (SSG). This technique reduced morbidity, hospital stay and work incapacity, as compared with patients treated by other methods.

Adolescent↗