[Pericardial effusion in the neonate: a complication of umbilical catheters].
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Cardiac Tamponade↗
Biomedical subjects
S E Karam
Publications and source records attributed to S E Karam.
Element-specific localization of Drosophila retrotransposon Gag proteins occurs in both nucleus and cytoplasm.
Many Drosophila non-long terminal repeat (LTR) retrotransposons actively transpose into internal, gene-rich regions of chromosomes but do not transpose onto chromosome ends. HeT-A and TART are remarkable exceptions; they form telomeres of Drosophila by repeated transpositions onto the ends of chromosomes and never transpose to internal regions of chromosomes. Both telomeric and nontelomeric, non-LTR elements transpose by target-primed reverse transcription, and their targets are not determined simply by DNA sequence, so it is not clear why these two kinds of elements have nonoverlapping transposition patterns. To explore roles of retrotransposon-encoded proteins in transposition, we analyzed intracellular targeting of Gag proteins from five non-LTR retrotransposons, HeT-A, TART, jockey, Doc, and I factor. All were expressed as green fluorescent protein-tagged proteins in cultured Drosophila cells. These Gag proteins have high levels of sequence similarity, but they have dramatic differences in intracellular targeting. As expected, HeT-A and TART Gags are transported efficiently to nuclei, where they show specific patterns of localization. These patterns are cell cycle-dependent, disappearing during mitosis. In contrast, only a fraction of jockey Gag moves into nuclei, whereas neither Doc nor I factor Gag is detected in the nucleus. Gags of the nontelomeric retrotransposons form characteristic clusters in the cytoplasm. These experiments demonstrate that closely related retrotransposon Gag proteins can have different intracellular localizations, presumably because they interact differently with cellular components. We suggest that these interactions reflect mechanisms by which the cell influences the level of transposition of an element.
Animals↗
Nursing home staff--nursing student partnership.
A partnership between a nursing home and a school of nursing provides both staff and students with creative opportunities for solving clinical problems. Through collaborative efforts of senior baccalaureate students and the staff administration of a long-term care facility in eastern Virginia, a successful bowel management program was developed and implemented.
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Student/staff collaboration: a pilot bowel management program.
1. Poor bowel elimination and constipation plague many individuals with advanced age. Moreover, the use of laxatives as the panacea for these concerns is far too common. 2. A successful bowel management program was implemented at the study facility through the collaborative efforts of baccalaureate nursing students and nursing home staff members. 3. The bowel management protocol involved increasing the amount of fiber, fluids, and exercise for each resident in the study. 4. The program demonstrated a definite decrease in the number of laxatives used by the subjects as well as an increase in the number of spontaneous bowel movements.
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