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Biomedical subjects

S E Knight

Publications and source records attributed to S E Knight.

8 recordsLinked to original sources
PubMed1978

The effect of highly selective vagotomy on the relationship between gastric mucosal blood flow and acid secretion in man.

Previous work has shown that the duodenal ulcer population can be defined by a lower ratio between gastric mucosal blood flow and acid secretion (during pentagastrin stimulation) than is found in normal subjects. The results of the present investigation have shown that the ratio is restored to normality by highly selective vagotomy. This suggests that increased tonic activity of the vagus on the parietal cell is one of the important disorders in duodenal ulceration.

Adult↗
PubMed1976

Decreased liver and lung drug-metabolizing activity in mice treated with Corynebacterium parvum.

Injections of killed suspensions of Corynebacterium parvum (i.p.) in young male mice were followed by time- and dose-dependent decreases in the drug-metabolizing activity of liver microsomes and lung homogenates. In vitro assays with model substrates [aminopyrine, aniline, p-nitroanisole, and benzo(a)pyrene] were used to quantitate drug-metabolizing activity. It is likely that such decreases in mixed function oxidases activity will act to significantly alter the pharmacokinetics of concurrently or subsequently administered drugs. The results provide a possible mechanism to explain several previously reported immunochemotherapeutic interactions.

Animals↗
PubMedDate not supplied

The effect of footwear on venous pressure at the ankle.

The response to exercise of venous pressure at the ankle was measured in two groups of normal subjects when barefoot, wearing normal shoes and in exercise sandals. The results demonstrate a significantly greater fall in venous pressure in exercise sandals than in shoes approximating to that of barefoot walking. In patients with superficial varices, the fall in venous pressure during exercise when wearing exercise sandals was again highly significant when compared to walking in shoes, approximating to normal values, and the possible therapeutic application of this finding is discussed.

Adult↗