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Biomedical subjects

S E Koonin

Publications and source records attributed to S E Koonin.

3 recordsLinked to original sources
PubMed2004

Changes in Earth's reflectance over the past two decades.

We correlate an overlapping period of earthshine measurements of Earth's reflectance (from 1999 through mid-2001) with satellite observations of global cloud properties to construct from the latter a proxy measure of Earth's global shortwave reflectance. This proxy shows a steady decrease in Earth's reflectance from 1984 to 2000, with a strong climatologically significant drop after 1995. From 2001 to 2003, only earthshine data are available, and they indicate a complete reversal of the decline. Understanding how the causes of these decadal changes are apportioned between natural variability, direct forcing, and feedbacks is fundamental to confidently assessing and predicting climate change.

Journal Article↗
PubMed2003

Vector space classification of DNA sequences.

Revisiting the problem of intron-exon identification, we use a principal component analysis (PCA) to classify DNA sequences and present first results that validate our approach. Sequences are translated into document vectors that represent their word content; a principal component analysis then defines Gaussian-distributed sequence classes. The classification uses word content and variation of word usage to distinguish sequences. We test our approach with several data sets of genomic DNA and are able to classify introns and exons with an accuracy of up to 96%. We compare the method with the best traditional coding measure, the non-overlapping hexamer frequency count, and find that the PCA method produces better results. We also investigate the degree of cross-validation between different data sets of introns and exons and find evidence that the quality of a data set can be detected.

Animals↗