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Biomedical subjects

S E Levin

Publications and source records attributed to S E Levin.

At least 37 records · Page 2Linked to original sources
PubMed1987

Systolic blood pressure differences in black, colored, and white infants.

Systolic blood pressure was measured in a random cluster sample of three-month-old black (n = 532), colored (n = 496), and white (n = 637) infants in Johannesburg, South Africa, by means of a Parks Doppler ultrasound device with a random zero sphygmomanometer. The study was conducted during a nine-month period in 1981. Major predictors of systolic pressure measurements were which fieldworker had taken the measurement and whether the child was quiet or agitated. After adjustment for predictors as necessary, the mean systolic blood pressure of black infants was about 2 mmHg higher than that of coloreds, which was statistically significant, with suggestive evidence that coloreds have a systolic pressure about 1 mmHg higher than that of whites. Findings at age three months may represent ethnic differences in blood pressure distributions of genetic origin.

Black People↗
PubMed1985

The upper limb-cardiovascular syndrome (Holt-Oram syndrome) in a South African family.

The upper limb-cardiovascular syndrome is reported for the first time in a South African family. There were 6 affected members in 3 generations. Infradiaphragmatic total anomalous pulmonary venous drainage, with obstruction, was found in 1 child. This rare cardiac abnormality, which constitutes only 8,5% of all cases of total anomalous pulmonary venous drainage, itself an unusual abnormality, has not previously been reported in association with the Holt-Oram syndrome.

Adult↗
PubMed1985

Asymmetric septal hypertrophy and hypothyroidism in children.

Any echocardiographic study of two children with hypothyroidism demonstrated the presence of asymmetric septal hypertrophy. One child died aged 11 months, and pronounced thickening of the interventricular septum was confirmed at necropsy. There was also hypertrophy of the left ventricular free wall. Histological examination showed only slight muscle fibre disarray, but there was striking vacuolation and hypertrophy of muscle fibres. In the second case, a child aged five years, the asymmetric septal hypertrophy disappeared after 18 months' treatment with L-thyroxine. Furthermore, other indices of myocardial function also returned to normal. The mechanism producing asymmetric septal hypertrophy in hypothyroidism is unknown. These are the youngest cases in which this association has been reported.

Cardiomegaly↗
PubMed1984

Hypertension as the major problem of idiopathic arterial calcification of infancy.

We describe two infants with severe hypertension associated with idiopathic arterial calcification of infancy. In both children, blood pressure control was refractory to aggressive antihypertensive therapy. There was radiologic and laboratory evidence of renovascular disease requiring the use of specific renin antagonists and later nephrectomy, resulting in moderate improvement of hypertension. Although on occasion there is a familial incidence, in the vast majority of cases the diagnosis hinges on a high index of suspicion.

Arteries↗
PubMed1983

Patch graft aortoplasty for repair of coarctation of the aorta in infants under 1 year of age.

Patch graft angioplasty for symptomatic coarctation of the aorta was carried out in 34 infants aged from 6 days to 9,5 months (mean 49,4 days). Congestive cardiac failure was present in 32 and severe hypertension alone in 2 patients. Of the 34 children, 21 (61,8%) had significant associated cardiac lesions and 25 (73,5%) were less than 6 weeks of age. Systolic blood pressures were recorded by the Doppler technique before and after the operation. There were 6 hospital deaths (17,6%) and 3 late deaths, giving a total mortality of 26,5%. Pre-operative systolic pressure gradients between upper and lower limbs ranged from 20 to 92 mmHg (mean 54,5 mmHg). Of the 28 early survivors, 1 was lost to follow-up. Duration of follow-up ranged from 3,5 to 62 months (mean 24,5 months). Postoperative residual gradients of less than 20 mmHg were found in 19 of the 27 cases followed up (70,4%), while 8 patients had significant residual gradients (40 - 90 mmHg). Of these 8, 7 had undergone surgery when less than 6 weeks old, and 6 of them have subsequently undergone a second corrective operation. It is concluded that while patch graft angioplasty is a life-saving procedure for the correction of symptomatic coarctation of the aorta in early infancy, a significant proportion of the patients develop a recurrence of coarctation necessitating further surgery later.

Aorta↗
PubMed1983

Infective endocarditis due to non-toxigenic Corynebacterium diphtheriae in a child. A case report.

A case of infective endocarditis (IE) in a 5 1/2-year-old boy in whom blood and bone marrow cultures yielded an unusual organism, a non-toxigenic strain of Corynebacterium diphtheriae, is reported. This proved fatal, and at autopsy congenital valvar aortic stenosis was found, but the vegetations occurred on an anatomically normal mitral valve. Organisms such as C. diphtheriae should not be ignored when isolated from blood cultures in suspected cases of IE.

Cardiomegaly↗
PubMed1983

Significance of hypertension in children.

This article does not consider the secondary causes of high blood pressure in children. Essential hypertension is a major factor in the morbidity and mortality from cardiovascular disease among adult populations throughout the world. The possibility that a raised blood pressure may have its origins in childhood or even in infancy is being extensively explored. Accurate measurement of blood pressure--especially systolic--is now feasible, by the Doppler technique, in very young children. The concept of "tracking" of blood pressure has been investigated. In addition, factors such as familial aggregation, genetic aspects, and the role of obesity in the etiology of hypertension have been considered. The reason for differences in the severity of manifestation of hypertension in black and white populations has not been satisfactorily elucidated, despite a number of childhood population studies. With an increased number of blood pressure measurements more children are being discovered with labile or even essential hypertension. The exact level above which to consider therapy is somewhat controversial. Nevertheless, even with mild persistent elevations, nonpharmacologic measures such as control of obesity, reduction in salt intake, regular exercise, potassium supplementation, and relaxation therapy, seem warranted. These measures should also be seriously considered in the prevention of hypertension in young urban populations.

Age Factors↗
PubMed1982

Surgical correction of combined supravalvular and valvular aortic stenosis in homozygous familial hypercholesterolaemia.

Although premature coronary atherosclerosis is a well-recognized complication of homozygous familial hypercholesterolaemia, involvement of the aortic root and valve has not been recognized frequently during life. Two cases of supravalvular and valvular aortic stenosis due to familial hypercholesterolaemia are described. Both patients underwent successful surgical correction of these lesions. The importance of relieving left ventricular outflow tract obstruction by a technique of aortic root enhancement and oblique insertion of a prosthesis is stressed.

Aortic Valve↗
PubMed1982

Hypoplasia or absence of the depressor anguli oris muscle and congenital abnormalities, with special reference to the cardiofacial syndrome.

An asymmetrical crying facies due to hypoplasia or absence of the depressor anguli oris muscle (DAOM) was observed in 23 infants and children. The cases were divided into two groups. Group 1 consisted of 12 patients who had associated cardiac abnormalities. In group 2 were 11 patients who either had other non-cardiac abnormalities (6) or no other abnormalities (5). The associated cardiac anomalies recorded in the literature are reviewed and 2 infants in this series are reported with abnormalities not previously described. The results of chromosomal analysis have generally been found to be normal, although a patient in our series was found to have trisomy E (18). The incidence of hypoplasia of the DAOM in newborn infants in a maternity hospital hospital is assessed and was found to be lower than reported in other studies. It is concluded that a detailed and careful examination for congenital abnormalities should be carried out on every child with an asymmetrical crying facies.

Child, Preschool↗
PubMed1982

Intracranial arteriovenous fistulas in infancy--haemodynamic considerations.

The clinical, electrocardiographic and radiological features and cardiac catheterization findings in 3 young infants with large intracranial arteriovenous fistulas are presented. In addition to the congestive cardiac failure, the haemodynamic disturbances which give rise to central cyanosis, pulmonary hypertension and, in some instances, poor peripheral pulses, are discussed. The cyanosis in these children may have been the result of a combination of right-to-left shunting at atrial or ductal level, as well as intrapulmonary shunting in association with pulmonary engorgement. Left ventricular dysfunction, with elevated end-diastolic pressures, appeared to be most marked in those cases in which poor peripheral pulses were present. Increased pulmonary arterial pressures (considerably greater than systemic arterial pressure in 2 of the cases) are considered to be due to a combination of the obligatory left-to-right shunt which results from the fistula, and to the super-added effect of altitude (1765 metres) with resultant pulmonary vasoconstriction.

Female↗
PubMed1981

Choanal atresia and congenital heart disease.

The association of congenital heart disease with choanal atresia is described in 6 infants (2 White, 3 Black and 1 Coloured). The literature is reviewed and 46 similar cases are analysed. The combination of choanal atresia and congenital heart abnormality generally carries a poor prognosis.

Female↗