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Biomedical subjects

S E Lieblich

Publications and source records attributed to S E Lieblich.

14 recordsLinked to original sources

Leiomyosarcoma presenting as a mandibular gingival swelling: a case report.

We report a case of primary low-grade leiomyosarcoma of the mandible in an otherwise healthy young woman. The neoplasm presented as a painful, pericoronal gingival swelling that mimicked an acute periodontal infection. It was managed accordingly, with curettage, debridement, and antibiotics. When the lesion failed to respond to this treatment approach, a biopsy was performed. Microscopy revealed a malignant mesenchymal neoplasm which, on immunohistochemistry analysis, demonstrated reactivity for smooth muscle actin (SMA) and vimentin. This established the diagnosis of leiomyosarcoma; subsequently, an en bloc resection of mandibular bone and overlying soft tissue was performed. Close follow-up for over 10 years has revealed no evidence of recurrent or metastatic disease. Since the patient was taking oral contraceptives prior to the onset of the lesion, a possible link between estrogen and smooth muscle tumors is considered.

Adult↗

Sialorrhea.

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Cholinergic Antagonists↗

Neurologic emergencies.

Neurologic emergencies are rare, and they usually occur in easily identifiable patients, provided that a thorough medical history has been previously obtained. Rare as these may be, however, they occur without warning and are potentially life threatening. Consequently, the dentist should be prepared by virtue of knowledge of the pathophysiology and therapy and by formal training and certification in basic life support.

Brain Diseases↗

Attenuation of anxiety in ambulatory oral surgery patients with oral triazolam.

The purpose of this investigation was to determine if the preoperative administration of an oral anxiolytic agent (triazolam) is beneficial in reducing the cardiovascular response to stress and anxiety. Twelve consecutive patients, six who received the drug and six who received a placebo, were monitored from the night before surgery at home until the morning with a Holter monitor. On presentation for surgery, levels of anxiety as well as heart rate and presence of cardiac arrhythmias were determined for the two groups. Patients who received the study medication had an anxiety level on the day of surgery similar to that recorded at an earlier consultation visit, whereas the placebo group showed a tendency toward an increase in anxiety on the day of surgery. There was a significant difference for resting heart rate between the two groups at various intervals associated with the preparation for the surgery. There were no complications related to the medication and, therefore, on the basis of this study, it appears that the administration of an oral anxiolytic agent prior to the patient presenting for surgery is beneficial in reducing the stress and anxiety associated with the operation as well as in reducing some of the cardiac manifestations of this stress.

Administration, Oral↗

Accidental intra-arterial injection.

The potential for an accidental intra-arterial injection is present whenever an intravenous route of drug administration is used. Because of the serious nature of the morbidity associated with this iatrogenic injury, and its preventability, this article is presented to update the available information on the etiology, diagnosis, treatment, and prevention of this problem.

Anesthesia, Intravenous↗

Origin of abscess.

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Brain Abscess↗

Changes in bone strength after augmentation with hydroxylapatite or hydroxylapatite/bone.

Adult, male New Zealand white rabbits had one humerus augmented with hydroxylapatite (HA) and one femur augmented with hydroxylapatite and autogenous, cortico-cancellous bone (HA-B). Contralateral bones were not augmented and used for controls. After periods of six and 16 weeks the animals were killed and the load sustained by the test and control bones at fracture was determined using three point loading. A significant increase in the load at fracture was noted in the bones augmented with either HA or HA-B.

Animals↗

The syndrome of inappropriate secretion of antidiuretic hormone in the maxillofacial trauma patient.

The maxillofacial trauma patient whose neurologic status undergoes a rapid and serious deterioration may have a severe hyponatremia secondary to the inappropriate secretion of antidiuretic hormone (SIADH). Other causes of hyponatremia must be ruled out, especially posttraumatic cerebral salt wasting, which necessitates a different mode of therapy. A case of SIADH is reported, and the work-up and differential diagnosis of posttraumatic hyponatremia are discussed.

Adolescent↗

Peripheral nerve injury during anesthesia.

A case is presented where a peripheral nerve injury occurred due to the pressure of a restraint buckle causing a postoperative motor and sensory deficit. Because these are iatrogenic injuries it is useful to review the mechanism of injury and means of prevention.

Adult↗