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Biomedical subjects

S E Milne

Publications and source records attributed to S E Milne.

5 recordsLinked to original sources
PubMed1998

Future applications for TCI systems.

Infusion pumps incorporating 'Diprifusor' for the administration of propofol by target controlled infusion are now commercially available and are becoming more widely used. This paper considers possible future applications of target controlled infusion and summarises results obtained using prototype systems as a component of other control techniques and with other drugs. These include studies with patient-controlled systems for the administration of analgesia or sedation and a closed loop control system for the administration of propofol. Among currently available analgesic drugs, alfentanil and remifentanil are considered to be the most suitable for administration by target controlled infusion, but commercial systems for these agents are not yet available.

Analgesia↗
PubMed1989

Factors affecting the accuracy of position matching at the proximal interphalangeal joint in human subjects.

1. The ability of normal subjects to match finger position at the proximal interphalangeal (PIP) joint was tested under a number of different conditions. One finger (target finger) was passively displaced in a pseudorandom manner whilst the other (matching) finger was actively positioned by the subject. 2. Digital nerve block of the target finger resulted in the matching finger only being displaced through a small range ('range compression') whilst anaesthesia of the matching finger produced the opposite effect ('range expansion'). 3. When the finger is unanaesthetized, the velocity of displacement of the target finger from one position to the next does not affect the accuracy of position matching. However, during digital nerve block of the target finger, matching errors increase with decreasing velocity. 4. The impairment of matching performance during digital nerve block is due specifically to loss of input from receptors in and around the PIP joint, as anaesthesia of the tip of the finger to produce any significant decrement in matching accuracy. 5. The results show that muscle receptors contribute to position sense at this joint but are not the exclusive source of proprioceptive sensations.

Fingers↗
PubMed1978

Incomplete anaerobiosis as a cause of metronidazole 'resistance'.

Clostridium welchii, used as a control, was found to grow well in a microaerophilic jar used for campylobacters but appeared resistant to a metronidazole disc although the campylobacter was sensitive. Minimum inhibitory concentrations for six strains of Cl. welchii were up to 64-fold higher in these conditions than when grown anaerobically. Zones of inhibition with both Cl. welchii and Bacteroides fragilis varied with the amount of air admitted to anaerobic jars.

Anaerobiosis↗