Biomedical subjects

S E Morse

Publications and source records attributed to S E Morse.

10 recordsLinked to original sources

PubMed1999

Oculomotor functions and late-onset myopia.

In order to elucidate the role of optical defocus in the development of late-onset myopia (LOM), we employed both theoretical and experimental approaches. In the theoretical study, which has been reported previously, we suggested a model in which an accommodative sensory operator was added to simulate the sensory part of the accommodation system. Results derived from the model showed that the sensory part might increase the system's threshold to the accommodative error (or defocus) signal. In this study, we measured the perceptual depth-of-focus and the system's threshold to the defocus signal for three refractive error groups: emmetropic (Emm), stable myopic (S.M.), and progressing myopic (P.M.). Results show that there are no significant differences in the perceptual depth-of-focus among the three groups. However, the defocus threshold values of the P.M. group are significantly higher than the values of the other two groups. This result in combination with our previous findings, leads us to suggest that individuals susceptible of developing myopia from sustained near-work have a specific oculomotor risk profile. Although we are still trying to determine the specific sequence of changes among dark-focus, AC/A ratio, the accommodative system's defocus threshold, and refractive error, we are convinced that the changes of oculomotor parameters underlie the type of myopia associated with near-work.

Accommodation, Ocular↗

PubMed1999

Oculomotor function after virtual reality use differentiates symptomatic from asymptomatic individuals.

UNLABELLED: Some individuals who use virtual reality (VR) head-mounted displays (HMD) have adverse visual symptoms. PURPOSE: We measured oculomotor functions of symptomatic (n = 10) and asymptomatic (n = 10) individuals to determine if there were fundamental oculomotor performance differences. METHOD: Before and after 20 min of biocular VR-HMD use, we measured: phorias, fixation disparity, gradient accommodative convergence to accommodation ratio (AC/A), stereopsis, and nearpoint of convergence. RESULTS: We observed an exophoric shift in the nearpoint phoria of almost all subjects, whereas the farpoint phoria showed no trend. Interestingly, we observed that the phoric shift at far and near was highly correlated for the asymptomatic subjects but not for the symptomatic subjects. In addition, the (stimulus) AC/A ratio of symptomatic subjects was reduced after a period of VR-HMD use, whereas asymptomatic subjects' AC/A ratio was not reduced. CONCLUSION: The oculomotor changes among the symptomatic subjects (increased exophoria at near and reduced AC/A) appears consistent with a reduced accommodative response. In contrast, the asymptomatic subjects show changes (correlated change in phorias) which seem most consistent with adaptation in the tonic component of vergence and/or accommodation.

Accommodation, Ocular↗

PubMed1995

Red-green opponent channel mediation of control of human ocular accommodation.

1. It has been hypothesized, but not verified empirically, that the control of human ocular accommodation is mediated by either the red-green or yellow-blue colour channels. Our goal was to determine experimentally whether the red-green channel by itself could influence the accommodative response. 2. To find out, we isolated the red-green channel through chromatic bandpass filtering and measured accommodation under dynamic and static conditions. The effect of this filtering was to modulate the red-green channel without disturbing either the yellow-blue or luminance channels. 3. Accommodative gain (ratio of response to stimulus amplitude) declined monotonically with decreasing bandwidth under dynamic conditions. Because the outputs of both the luminance and yellow-blue colour channels did not vary with bandwidth, the only explanation is that the red-green opponent process was responsible for the effect. 4. Under static conditions, however, accommodation was independent of bandwidth. This may be attributable to the decreased sensitivity to chromatic contrast that occurs at low temporal frequencies.

Accommodation, Ocular↗

PubMed1995

Purine-purine mismatches in RNA helices: evidence for protonated G.A pairs and next-nearest neighbor effects.

Thermodynamic parameters are presented for 12 different RNA duplexes containing A.A, A.G, G.A and G.G mismatches flanked by C-G base pairs. UV melting studies were conducted under three different buffer conditions in order to evaluate the effects of salt concentration and pH on the stability of each mismatch-containing duplex. The main findings are: (i) the mismatches have a wide range of effects on duplex stability, decreasing delta G degrees 37 of denaturation by approximately 0-7 kcal/mol; (ii) the nearest-neighbor assumption commonly used to calculate helix stability breaks down for G.A mismatches; and (iii) G.A mismatches separated by 2 bp form a protonated structure.

Adenine↗

PubMed1995

The effect of perceived distance on accommodation under binocular steady-state conditions.

Spatiotopic cues, such as perceived distance, have little effect on accommodation unless blur has been reduced or eliminated. We investigated the effect of perceived distance on accommodation under binocular steady-state conditions, about which little is known. Blur was reduced but not eliminated by using a stimulus with a moderately low luminance. Accommodation was measured under two conditions: (1) when cues from perceived distance, blur, and convergence were aligned; and (2) when perceived distance was opposed by both blur and convergence. We found a significant difference in accommodation between the two conditions, which we attribute to perceived distance.

Accommodation, Ocular↗

PubMed1995

Oculomotor responses with aviator helmet-mounted displays and their relation to in-flight symptoms.

Previous experiments have raised the possibility that abnormal oculomotor functioning could be the substrate for visual problems among aviators who use helmet-mounted displays. However, until the present investigation, no direct evidence linked the two. In our experiments, experienced Apache helicopter pilots, using the same helmet-mounted display that they use in flight, viewed Apache symbology and sensor imagery while we measured their accommodation and vergence eye movements in the laboratory. We found three circumstances that frequently occur in flight in which aviators with visual symptoms had different oculomotor responses than did asymptomatic aviators. Further work needs to be done to determine why symptomatic aviators respond differently from asymptomatic ones.

Accommodation, Ocular↗

PubMed1995

Optical compensation for night myopia based on dark focus and CA/C ratio.

PURPOSE: To determine whether individual differences in dark focus and convergence accommodation to convergence (CA/C) ratio can be used to prescribe the best optical correction for night myopia. METHODS: The best correction for night myopia was obtained by measuring visual acuity and contrast sensitivity across a range of lens powers and luminances. Dark focus was measured with an infrared optometer, and CA/C ratio was measured with an infrared optometer and eyetracker. Only young subjects were used (mean age = 25.4 years). RESULTS: Optimal lens power was significantly correlated with dark focus, regardless of CA/C ratio. However, the slope of the regression line relating lens power to dark focus was steeper for subjects with CA/C ratios less than 0.4 diopters/meter angle (D/MA, n = 7) than for subjects with CA/C ratios greater than 0.4 D/MA (n = 9). The mean CA/C ratio for the entire sample (n = 16) was 0.59 D/MA. The mean optimal lens power and dark focus were -0.79 and 0.74 D, respectively, for the low CA/C group, and -0.60 and 0.91 D, respectively, for the high CA/C group. CONCLUSIONS: Visual performance in night myopia can be optimized by taking into account intersubject differences in dark focus and CA/C ratio. Best visual performance was found with a lens roughly equaling the full dark focus for subjects with low CA/C ratios and half the dark focus for subjects with high CA/C ratios.

Accommodation, Ocular↗

PubMed1994

The effect of knowledge of object distance on accommodation during instrument viewing.

We present data in which instrument accommodation was measured while knowledge of object distance was varied. The accommodative feedback loop was 'semiopen'--an intermediate state between the closed-loop and open-loop conditions of previous experiments. The semiopen-loop situation mimicked the degraded-image conditions which are frequently encountered during instrument viewing. The results show that for some subjects knowledge of object distance is a more powerful cue for instrument accommodation than is the optical distance of the object; however, for the majority of subjects this is not the case. We also found that subjects whose accommodation is influenced by knowledge of object distance tend to have a more proximal dark focus than those whose accommodation is independent of knowledge of object distance. We propose that the Mandelbaum effect, in which involuntary accommodation occurs when a transparency is superimposed between the observer and the object of regard, could account for the accommodative behavior of all subjects. However, the Mandelbaum effect would have to be interpreted more broadly than before. In the broader interpretation, the transparency could be cognitive (ie known distance) rather than physical.

Accommodation, Ocular↗

PubMed1994

Relationship among accommodation, focus, and resolution with optical instruments.

We studied instrument myopia as an overall effect consisting of interactions among the observer's accommodation and resolution during instrument viewing and the manner in which the instrument is focused. Previous investigations of instrument myopia generally have been limited to only one of these variables. Our results are consistent with the dark-focus-bias theory of accommodation, which holds that accommodation tends to seek its resting point, or dark focus, whether or not the observer is viewing through an optical instrument. The amount of accommodation measured during instrument viewing was found to be dependent on instrument design features that modulate the bias of accommodation for the dark focus.

Accommodation, Ocular↗

PubMed1994

Focus adjustment effects on visual acuity and oculomotor balance with aviator night vision displays.

Sixteen U.S. Army aviators, who were given training on focus adjustment technique with aviator night vision goggles (NVG), showed an improvement in visual acuity with focus adjustment compared to a fixed infinity focus control. The long-term effect of focus adjustment on vision was not measured; however, adjustment accuracy was found to be generally within acceptable limits based on computer modeling and available physiologic data. Fixed focus eyepieces that are set to a low minus power may partially compensate for instrument myopia, but they may not optimize visual acuity to the extent that adjustable focus eyepieces do. Eyepiece adjustment proficiency with present night vision devices can be improved through training that emphasizes focusing to the least possible minus dioptric power. Future night vision displays can minimize focus misadjustment by providing a tactile zero marking, a limited dioptric adjustment range, and a focusing knob capable of finer adjustment than is available with current NVG's.

Aerospace Medicine↗