Biomedical subjects

S E Romagnoli

Publications and source records attributed to S E Romagnoli.

5 recordsLinked to original sources

PubMed1996

Luteolytic effects of prostaglandin F2alpha on day 8 to 19 corpora lutea in the bitch.

Luteolysis was induced in 5 experimental Beagle (8 cycles) and 7 client-owned bitches treated with 150 to 200 microg/kg, sc of prostaglandin F2alpha administered twice daily for 4 d, starting on Days 8 to 19 after the onset of cytological diestrus. Five experimental Beagle bitches had been mated during the estrus preceding treatment, and copulation had been confirmed in 2/7 client-owned bitches presented for termination of unwanted pregnancy. Serum progesterone concentration (mean +/- SD) declined from 26.1 +/- 66 ng/ml before treatment to 0.3 +/- 0.4 ng/ml on the fourth day of treatment One of the 7 client-owned bitches maintained her pregnancy even though serum progesterone concentrations were less than 0.5 ng/ml on the third and fourth day of treatment. Mean (+/- SEM) inter-estrous intervals before and following prostaglandin-induced luteolysis were 207.3 +/- 12.4 (n = 11 cycles in 6 bitches) and 95.5 +/- 20.0 d (n = 6 cycles in the same 6 bitches; P < 0.0001), respectively These results suggest that effective prostaglandin-induced luteolysis can be achieved with administration of 180 microg/kg during the third week of diestrus in pregnant and nonpregnant bitches.

Journal Article↗

PubMed1993

Clinical use of prostaglandin F2 alpha to induce early abortion in bitches: serum progesterone, treatment outcome and interval to subsequent oestrus.

Records of elective abortion in 27 bitches presented to the Veterinary Surgery and Reproduction Clinic of the University of Pisa were reviewed. Treatment consisted of twice-daily subcutaneous injections of 150-270 micrograms natural prostaglandin F2 alpha kg-1 for 4 consecutive days starting between cytological dioestrous days 5 and 19. None of the treated bitches whelped. Luteolysis appeared to be complete (serum progesterone < 3.2 nmol l-1) at the end of treatment in 22 of 25 bitches in which progesterone was assayed in serum obtained daily during therapy. Serum progesterone rose after treatment to a concentration consistent with pregnancy in four of 17 bitches in which progesterone was measured once between dioestrous days 23 and 51. The mean intercycle interval (pro-oestrus-pro-oestrus) of the cycle in which abortion was induced was 134 +/- 45 days for 15 dogs for which the interval could be determined, and was significantly shorter than the average preceding interoestrous intervals (210 +/- 40.0 days) for the same dogs (P < 0.001).

Abortifacient Agents↗

PubMed1991

Use of prostaglandin F2 alpha for early pregnancy termination in the mismated bitch.

Natural PGF administered at a dose of at least 250 micrograms/kg twice daily subcutaneously for at least 4 days starting no earlier than day 5 of cytologic diestrus induces luteolysis and pregnancy termination in the mated bitch. The resulting shortening of the luteal phase is associated with a shortening of the interestrous interval from 1 to 4 months. Bitches treated with PGF show emesis, diarrhea, and panting within 5 minutes and transient hypothermia which lasts 2 to 3 hours but generally have no further reaction. Bitches with cardiac or respiratory dysfunctions are not considered safe patients for early pregnancy termination with PGF because of the cardiovascular effects of this drug. Bitches treated with this regime early in diestrus resorb their conceptuses; those treated after days 35 to 40 show clinical abortion of viable fetuses.

Abortion, Induced↗

PubMed1991

Canine cryptorchidism.

Canine cryptorchidism is a congenital defect that results from sex-limited autosomal recessive gene(s). Incidence is higher in some breeds, especially in smaller and inbred ones. Parents of affected puppies are carriers. Unilateral cryptorchid dogs can be fertile, and affected individuals and their siblings should be eliminated from a breeding program to decrease incidence of the defect. Androgen and gonadotropin treatments have been tried with little or no success. Bilateral orchidectomy is the treatment of choice because of the common sequelae of testicular neoplasia and torsion.

Animals↗

PubMed1987

Multiple recurring uterocervical leiomyomas in two half-sibling Appaloosa fillies.

Two yearling, paternal half-sibling Appaloosa fillies were ovariohysterectomized for treatment of multiple uterocervical leiomyomas. The tumors recurred in both fillies, originating from cervical tissue that could not be removed at surgery. Previously reported cases of uterine leiomyoma in the mare have been of solitary tumors in older mares that were treated successfully by surgical removal.

Animals↗