Biomedical subjects

S E Vernon

Publications and source records attributed to S E Vernon.

23 records · Page 2Linked to original sources

PubMedDate not supplied

Sézary cells in ascitic fluid.

Sézary's syndrome is a neoplasm of T-lymphocytes characterized by skin lesions histologically typical of mycosis fungoides together with the presence of malignant (Sézary) cells in the peripheral blood. These cells have a characteristic appearance in tissues, peripheral blood and body fluids, and their presence in large numbers in ascitic fluid is an indicator of disseminated disease. A patient with Sézary's syndrome was found to have the distinctive malignant lymphocytes in ascitic fluid. We believe that this report is the first to document the appearance of the cells in a body cavity fluid. Treatment modalities in Sézary's syndrome may be determined by the stage of the disease, and the presence of the distinctive "convoluted" or "cerebreform" lymphocytes should be noted.

Ascitic Fluid↗

PubMedDate not supplied

Nodular pulmonary sarcoidosis. Diagnosis with fine needle aspiration biopsy.

A case of sarcoidosis presenting as multiple pulmonary nodules and investigated by transthoracic fine needle aspiration biopsy is presented. Cohesive clusters of epithelial cells as well as multinucleated giant cells were observed. Special stains performed on the cell-block preparation were useful in ruling out an infectious etiology. The case demonstrates the value of fine needle aspiration biopsy in the investigation of pulmonary parenchymal disease and illustrates the cytologic findings in this unusual presentation of sarcoidosis.

Adult↗

PubMedDate not supplied

Cytologic features of nonfatal herpesvirus tracheobronchitis.

Herpesvirus infections of the lower respiratory tract have most commonly been reported in patients with severe burns, immunosuppression or malignancies. Two patients without any of these underlying conditions developed severe herpetic tracheobronchitis, diagnosed by cytologic examination and confirmed by serologic studies. Serial examination of sputum, bronchial brushings and bronchial washings permitted observation of the evolution and progression of cellular changes found in herpesvirus infection of the lower respiratory tract. both patients recovered without specific antiviral therapy, but both developed superinfection with gram-negative organisms, requiring intensive antibiotic therapy. The distinctive features of herpesvirus infection in the tracheobronchial tree are similar to those recognized elsewhere in the body. Early findings include a variety of nonspecific changes in nuclear chromatin configurations; multinucleated cells may be common but do not often contain the central intranuclear inclusion bodies seen in later stages. These distinctive central intranuclear inclusions disappear in a few days, leaving only reparative changes in the surface epithelium. Herpesviruses are increasingly being reported in the literature as an etiologic agent of acute tracheobronchitis in otherwise healthy individuals.

Bronchi↗

PubMedDate not supplied

Immunoglobulin light chain staining of lymph node biopsies: an interlaboratory comparison.

In recent years, the demonstration of cell surface or cytoplasmic monoclonal immunoglobulin kappa or lambda light chains in lymphoid tissues has been considered evidence of their B-cell origin. In an effort to evaluate the reproducibility of results among various laboratories performing immunoperoxidase immunostaining of lymph node specimens, 12 lymph node biopsies were similarly fixed and processed, and serial sections submitted to four laboratories for staining by the unlabelled antibody (peroxidase-antiperoxidase conjugate) technique. Seven of these were malignant lymphomas four were negative, and one was metastatic carcinoma. Participants were not told the diagnosis and were asked to evaluate each specimen for the presence of monoclonal light chain staining. While the overall agreement in results were good, one of four laboratories differed from the other three in four out of the 12 cases. The significance of this finding and its implications are discussed.

Carcinoma↗

PubMedDate not supplied

Cytodiagnosis of "signet-ring"-cell lymphoma.

An unusual case of malignant lymphoma with vacuolated cells was discovered during examination of pulmonary cytologic specimens. The diagnosis was confirmed by light and electron microscopic study of biopsy specimens. This variant of malignant lymphoma could be mistaken for adenocarcinoma or carcinoid tumor, but certain cytologic features common to malignant lymphomas should help to differentiate these neoplasms. The histologic, immunohistochemical and electron microscopic findings confirm the diagnosis. As more pathologists and cytologists become aware of this entity, additional cases will probably be reported. The significance of the morphologic findings is as yet uncertain.

Aged↗