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Biomedical subjects

S Eckert

Publications and source records attributed to S Eckert.

52 records · Page 3Linked to original sources

[Use of the laryngeal mask in difficult intubation].

Although the incidence of difficult airway is very low, involving less than 1% of all patients, failed air-way management is the main cause of mortality or serious morbidity during anaesthesia. Successful management of a difficult airway starts with recognition of the potential problem. A careful preoperative history and clinical examination should elicit obvious problems to allow prediction of a potentially difficult airway. Besides the introduction of different instruments and techniques, the laryngeal mask (LMA) has been suggested to be effective both in when difficult airway is known in advance to be present and after failed intubation. CASE REPORT. The use of the LMA in a patient scheduled for endoscopic resection of a ureteral stone as day surgery is described. The patient presented reduced mobility of the atlanto-occipital joint, temporomandibular ankylosis (mouth opening of 1.9 cm), dislocated teeth, and kyphosis of the thoracic spine. Due to deformation of the spine, the patient was placed in a half-sitting position (30 degrees). Anaesthesia was induced with fentanyl (1.5 micrograms.kg-1) and propofol (2 mg.kg-1). Although the conditions made it difficult to manage the patient's airway, the LMA was inserted without complications or trauma. Anaesthesia was maintained with isoflurane and nitrous oxide in oxygen. After 1.5 h of assisted ventilation the LMA was removed when the patient opened his mouth on request. DISCUSSION. Significant advances in the management of the difficult airway have been achieved in recent years. However, avoidable deaths on intubation have been attributed to unexpected difficulties and poorly managed situations. Thus every anaesthetist should be prepared for potential difficulties by training and be able to follow a rational plan of action. If despite all manoeuvres a tracheal tube cannot be passed, a failed intubation drill must be instituted, and if oxygenation is still not possible a failed ventilation drill must be followed. The LMA is a new device developed to provide an airway for anaesthesia. However, since the LMA can be inserted quickly and blind, it can be used as an alternative airway in patients in whom the trachea is difficult to intubate. The lower incidence of post-operative complications than with endotracheal intubation is a further advantage, particularly during anaesthesia for day surgery.

Aged↗

Hydroxyurea: effects on hemoglobin F production in patients with sickle cell anemia.

Patients with sickle cell anemia were treated with daily doses of hydroxyurea, to assess pharmacokinetics, toxicity, and increase in fetal hemoglobin (Hb) production in response to the drug. Plasma hydroxyurea clearances were not a useful guide to maximum tolerated doses of the drug. The mean daily single oral dose that could be maintained for at least 16 weeks was 21 mg/kg (range, 10 to 35 mg/kg). Among 32 patients, last HbF levels were 1.9% to 26.3% (mean, 14.9%) with increases in HbF over initial values of 1.4% to 20.2% (mean, 11.2%). The most significant predictors of last HbF were last plasma hydroxyurea level, initial white blood count and initial HbF concentration. Last HbF was not related to beta globin haplotype or alpha globin gene number. No serious toxicity was encountered. Clinically significant bone marrow depression was avoided, and chromosome abnormalities after 2 years of treatment were no greater than those observed before treatment. The period of observation has been too short to evaluate the risk of carcinogenesis. Patient's red cells developed striking macrocytosis. Median red cell Hb concentrations did not change. Hb concentrations increased, on average 1.2 g/dL, but serum erythropoietin levels increased. Patients' body weights increased, and some returned to work or school, but no conclusions regarding therapeutic efficacy could be drawn from this uncontrolled open-label study.

Adult↗

Percutaneous transluminal angioplasty of aortocoronary venous bypass grafts and effect of the caliber of the grafted coronary artery on graft stenosis.

The influence of morphologic parameters on the recurrence of stenosis after percutaneous transluminal coronary angioplasty of 49 stenoses in aortocoronary venous bypass grafts of 41 patients was investigated. Vessel dimensions were measured quantitatively. Angioplasty was successful in 46 stenoses (94%) of 38 patients (93%). In 35 patients (92% of successfully treated patients) with 42 stenoses, control angiography was performed after a mean interval of 189 +/- 186 days. In 9 patients (26%), 9 stenoses (21%) had recurred. The diameter of the grafted coronary artery distal to the anastomosis was significantly smaller in grafted arteries with than without recurrent stenoses (1.92 +/- 0.52 vs 2.45 +/- 0.50 mm; p less than 0.01). Recurrence also correlated with the ratio between graft diameter and coronary artery diameter greater than 1.35 (p less than 0.02) and with the stenosis length greater than 10 mm before angioplasty (p less than 0.01). Graft age, graft diameter and stenosis location in the graft had no significant influence on recurrence. Thus, the diameter of the grafted coronary artery and the length of the critical stenosis are parameters for recurrence after angioplasty of graft stenoses and should be considered in the selection of patients for this intervention.

Aged↗

[Percutaneous, transluminal angioplasty of aortocoronary venous bypass grafts--acute success, angiography and clinical follow-up].

In 41 consecutive patients with 49 stenoses of aorto-coronary venous bypass (ACVB) grafts percutaneous transluminal angioplasty (PTA) was attempted. PTA was successful, i.e., the percent area stenosis was reduced by greater than 20% to less than 70% (quantitative measurement with a precision magnifying lens from two orthogonal angiographic views) in 46 stenoses (94%) of 38 patients (93%). In 35 patients (92%) with 42 stenoses control coronary angiography was performed after a mean interval of 189 +/- 186 days. Recurrence, defined as an increase of percent area stenosis to greater than or equal to 70%, was found in nine stenoses (21%) of nine patients (26%). Recurrence correlated with a stenosis length greater than 10 mm before PTA (5/8 vs 4/32 stenoses: p less than 0.01). In recurrent stenoses, the average diameter of the grafted native coronary artery was significantly smaller than in recurrence-free stenoses (1.92 +/- 0.52 mm vs 2.45 +/- 0.50 mm; p less than 0.01). Clinical data were collected from all 38 patients with successful PTA after an average of 30 +/- 17 months following PTA. In this interval, 11 patients had undergone re-angioplasty and eight patients were re-operated; in addition, there were three cardiac deaths. In the 27 surviving patients without re-operation (71%), angina pectoris had improved from a mean of 3.0 +/- 0.7 before PTA to 1.8 +/- 1.0 (CCS-classification) (p less than 0.001). In 19 of the 27 patients (70%) the exercise stress test was negative, in contrast to only three patients (11%) before PTA. Thus, in the majority of patients PTA of ACVB-graft stenoses improves quality of life.(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗

Measurement of atactic and paretic gait in neuropathies of rats based on analysis of walking tracks.

In 23 Lewis rats 2 forms of neuropathy both with atactic gait were studied by morphometric analysis of walking tracks. In one group of animals experimental allergic neuritis (EAN) was induced which leads to both sensory and motor dysfunction. Clinical symptoms are atactic gait and hindlimb paresis. In another group pyridoxine (vitamin B6) neuropathy was induced which is a purely sensory neuropathy clinically presenting with gait ataxia, too. Track analysis is a simple method that requires no visualisation process and produces significant and reproducible data. The findings were compared with the clinical scores and electrophysiological data. In EAN, toe spreading was impaired early, and at a later stage stride width, print length and outward rotation of the hind feet changed. Pyridoxine-induced neuropathy produced only an increase in stride width. Track analysis correlated well with clinical grading and electrophysiological recordings. We propose track analysis as a reliable and accurate indicator of neuropathy symptoms in rats.

Animals↗

[Bradycardia factitia].

Repeated intake of 240-400 mg non-retard verapamil by a 26-year-old male nurse brought about interference dissociation resulting from extreme sinus bradycardia, passive AV nodal rhythm and hypotension. Because of a history of myocarditis a recurrence was suspected and an organic cause of the arrhythmia assumed at first, until its self-inflicted origin was discovered. The case demonstrates the need to consider self-medication, even if at first denied, in the differential diagnosis of arrhythmias even in the absence initially of any clear-cut pointers towards it.

Adult↗

Assessment of left ventricular function during angina pectoris from the mitral valve echogram.

The echocardiographic motion pattern of the anterior mitral valve (aMV) has been shown to be related to left ventricular function. In an attempt to quantify the changes of aMV motion in patients during myocardial ischemia, the following motion phases of the aMV echo were determined in 12 patients with coronary artery disease: DE slope, EF slope, the closure slope of the aMV, as determined by joining points B and C (or in the absence of a clearly definable B point the AC slope), and the systolic motion pattern. Following coronary angiography, measurements of the aMV echo were performed in the resting state and during angina pectoris immediately after rapid atrial pacing at comparable heart rates. DE slope and EF slope showed only minor and insignificant changes during angina in the post-pacing period. The aMV closing velocity (BC or AC slope) was significantly reduced from 225.9 +/- 56 mm/sec during the control period to 177.9 +/- 43 mm/sec during angina (p < 0.01). After recovery from anginal pain measurements of the final closing velocity revealed a return to the control values with an average slope of 240.4 +/- 40 mm/sec. In 3 of 12 patients there was evidence of systolic mitral valve prolapse during the post-pacing anginal episode. Our results suggest that final mitral valve closing velocity reflects changes in left ventricular function during myocardial ischemia in the early isovolumetric phase of ventricular systole. In some patients mitral valve prolapse during angina may indicate ischemic dysfunction of the papillary muscles during the ejection of phase of systole.

Adult↗

Synchronous independent lung ventilation.

Ventilated patients with unilateral lung disease present a unique challenge because each lung requires independent FiO2, PEEP, and mode settings. With early implementation of Synchronous Independent Lung Ventilation, each lung is treated individually and chances for survival may increase. Critical care nurses face new challenges in assessing and preventing complications for these patients.

Critical Care↗

Surgical-prosthodontic reconstruction of advanced maxillary bone compromise with autogenous onlay block bone grafts and osseointegrated endosseous implants: a 12-year study of 32 consecutive patients.

During a 12-year period (1984 to 1997), 32 consecutive patients with advanced maxillary bone compromise received surgical-prosthodontic rehabilitation. The most frequent procedure used was maxillary augmentation with a free nonvascularized autogenous onlay block bone graft, and the average time of prosthesis function was 67 months. Twenty-eight patients underwent a 1-stage procedure, in which endosseous implants were placed simultaneously for internal rigid skeletal fixation of the onlay bone graft, and 4 patients underwent a 2-stage procedure, in which endosseous implants were placed secondarily 6 months after complete healing of the previously placed onlay bone graft, which initially was stabilized by titanium miniplates and lag screws. Treatment success was evaluated separately for the first 7 consecutively treated patients (developmental group) and for the next 25 consecutive patients (routine group). Assessment was made of implant survival relative to etiology of bone loss, implant type and length, type of prosthesis, type of opposing occlusion, type of surgical procedure, and presence of discontinuity. The implant survival rate was 91% in the 25 routine patients and 65% in the 7 developmental patients. Implant type and length, prosthesis type, opposing occlusion, and the presence or absence of discontinuity significantly impacted treatment outcome. Onlay block bone graft success (96%) in all 32 treated patients and prosthetic success (96%) in the last 25 patients was recorded.

Adolescent↗

TGF-beta isoforms and fibroblast growth factor exhibit analogous indirect antioncogenic activity through triggering of intercellular induction of apoptosis.

TGF-beta-1 has recently been shown to trigger nontransformed effector cells to induce apoptosis specifically in transformed cells. This intercellular induction of apoptosis has been discussed as a potential control step in oncogenesis. Here we show that triggering of intercellular induction of apoptosis is not a non-specific growth factor effect, but is restricted to the TGF-beta and FGF family of growth factors. Within the TGF-beta family, all isoforms triggered the intercellular induction of apoptosis with the same efficiency. This finding illustrates that these effects observed have been conserved throughout evolution, which thus points to their potential biological significance. The parallel action of TGF-beta and FGF in the intercellular induction of apoptosis correlates with the role of both families of factors in the establishment and maintenance of the transformed state. Autocrine loops of either growth factor seem to be recognized by the surrounding nontransformed cells and to evoke an apoptosis- inducing effect which thus prevents the survival and outgrowth of potential tumor cells.

Animals↗

Endosseous implant and autogenous bone graft reconstruction of mandibular discontinuity: a 12-year longitudinal study of 31 patients.

Surgical, medical, and prosthodontic records of 61 consecutively treated patients with mandibular discontinuity were reviewed retrospectively. All 61 patients had undergone discontinuity reconstruction with autogenous bone grafts; 31 of 61 had also received endosseous dental implants and a dental osseoprosthesis. Of these 31 implant-reconstructed patients, 23 had free autogenous nonvascularized and 8 had vascularized bone grafts. The surgical-prosthetic protocol consisted primarily of secondary, free autogenous nonvascularized bone graft reconstruction and secondary root-form endosseous implant and fixed prosthesis dental reconstruction. Vascularized bone (8 patients) or soft tissue (4 patients) grafts were utilized selectively for severely compromised patients after extensive oncologic resection, avulsive trauma, or after previous radiation treatment. Endosseous implant survival (95.5% in 31 patients), autogenous bone graft success (98.4% in 61 patients), and dental osseoprosthesis success (100% in 31 patients) were favorable. A high incidence (9.1%) of nonfunctioning (sleeping) implants was recorded for this patient population. The need to remove the titanium mesh tray for various reasons (17.6%) and the need to reconstruct soft tissue in the irradiated patient (12%) were noteworthy.

Adolescent↗