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Biomedical subjects

S Eriksen

Publications and source records attributed to S Eriksen.

24 records · Page 2Linked to original sources
PubMed1977

Effects of precurarization on the heart measured by systolic time intervals.

The effects of precurarization, with or without prior atropine medication, on heart rate, systolic time intervals (preejection period (PEP) and left ventricular ejection time (LVET)) and derivatives from these were studied in 80 healthy patients before minor surgery. Atropine (0.5-0.7 mg i.v.) exerted a vagolytic action with no changes in systolic time intervals. D-tubocurarine (0.5 mg/kg b.w.) did not affect heart rate or systolic time intervals. Both gallamine (0.3 mg/kg b.w.) and pancuronium (0.015 mg/kg b.w.) increased heart rate due to the inherent vagolytic effect. Furthermore, a short-lasting decrease in PEP and an increase in LVET were demonstrated. Consequently, a fall in PEP/LVET and a rise in 1/PEP2 were induced, indicating an increase in cardiac pump performance. These changes were blocked by prior atropine medication, a result which is not easily explainable. Possible clinical implications are discussed.

Adolescent↗
PubMed1975

Cleaning hydrophilic contact lenses: an overview.

The composition of the major, critical component of the amorphous deposits forming on hydrophilic lenses during wear was identified and reported by Karageozian as basically proteinaceous in nature. The research surrounding the identification has produced animal and laboratory models for testing the parameteres involved in the protein deposition, as well as in its removal. A standardized system for classifying the protein deposits during and after formation, along with the experimental animal and laboratory models allows a relatively complete development of the predictive tests required for a compound or a product intended for use as a cleaner of hydrophilic lenses. These predictive tests have been run on several available cleaning systems as well as on a new one; the results indicate clearly that, unlike the available systems, the new system will safely remove deposits from hydrophilic lenses. The laboratory predictive test results have been borne out by clinical trial; the clinical results indicate the suitability of the new formulation and the predictive capability of the test models developed.

Animals↗
PubMedDate not supplied

A multiattribute-utility-function approach to weighing the risks and benefits of pharmaceutical agents.

Both the selection of doses of pharmaceutical agents and comparisons between pharmaceutical agents have long been based on the nonquantified concept of the risk-benefit ratio. Though useful, this concept implies a data comparison that is difficult to make: the toxicity versus the efficacy of a drug compound. This research demonstrates an approach for weighing risks and benefits by combining utility functions for human efficacy and toxicity with animal and laboratory toxicity information to develop an overall multiattribute utility function for an ophthalmic pharmaceutical agent, I-bunolol, intended for the treatment of glaucoma. With this multiattribute function and a small portion of the published data available for this drug, the expected utilities for six doses (including a control) could be compared and the value of this approach in drug-dosage selection demonstrated.

Decision Making↗