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Biomedical subjects

S Eyanson

Publications and source records attributed to S Eyanson.

11 recordsLinked to original sources
PubMed1986

Serum amyloid A in carcinoma of the lung.

Serum concentrations of serum amyloid A protein (SAA), peripheral blood lymphocytes (PBL) mitogenic response to phytohemagglutinin (PHA) and Concanavalin A (Con A), numbers of circulating T- and B-lymphocytes and length of survival after diagnosis were measured in 50 patients with cancer of the lung. SAA levels were significantly elevated when compared to 50 control subjects (P less than 0.001), but did not correlate with state of tumor spread at the time of diagnosis. Mitogenic responses of PBL from the cancer patients to PHA and Con A were significantly depressed (P less than 0.001), but also did not predict state of metastatic spread. The percentage of circulating T-lymphocytes was also significantly depressed in cancer patients when compared to controls. In six patients who survived tumor-free for greater than 2.5 years, SAA serum concentrations returned to normal. Statistical analysis showed a significant correlation between SAA serum concentrations and PBL mitogenic response to Con A. In addition, both high SAA concentrations and depressed PBL responses to Con A correlated with shortened survival. Therefore, these parameters may be of value in evaluating prognosis in patients with lung cancer. In addition, serial monitoring of SAA concentrations may be of value in evaluating recurrence or cure of lung cancer.

Adenocarcinoma↗
PubMed1984

Osteoarthritis.

Osteoarthritis is one of the oldest and most common forms of arthritis afflicting human beings. Once thought to be a result of normal aging, it is now recognized to be a complex and dynamic event. An individualized teaching program frequently brings about satisfactory relief and gratifying improvement.

Adrenal Cortex Hormones↗
PubMed1983

Erosive arthritis in hereditary amyloidosis.

Nine patients from 2 distinct kindreds with familial amyloidosis had episodes of inflammatory arthritis and radiographic evidence of joint erosions. Histologic features from erosive lesions in both kindreds showed proliferation of synovium with erosive bone and cartilage change. No large amyloid deposits were seen. This study indicates that an erosive synovitis of unknown cause may be a feature of some forms of hereditary amyloidosis.

Aged↗
PubMed1982

Erosive temporomandibular joint disease as a feature of the spondyloarthropathy of ulcerative colitis.

A patient with ankylosing spondylitis associated with ulcerative colitis developed bilateral temporomandibular joint pain and severe restriction of jaw motion. Conventional radiographs did not show structural abnormality of the temporomandibular joints, but corrected axis tomography revealed erosions in both mandibular condyles with extensive reactive sclerosis in the subchondral bone. These findings suggest that the temporomandibular joint disease in this case was a feature of the patient's spondylitis rather than a manifestation of the peripheral joint arthritis which commonly occurs in patients with ulcerative colitis.

Adult↗
PubMed1980

Methylprednisolone pulse therapy for nonrenal lupus erythematosus.

High-dose intravenous methylprednisolone therapy has previously been shown to be efficacious in the treatment of renal lupus erythematosus. The present report presents 2 patients with life-threatening, nonrenal lupus erythematosus. One patient had coma and seizures, while the other had sever thrombocytopenia and anaemia. Both had failed to respond to oral corticosteroid therapy in high doses but had dramatic clinical responses with intravenous methylprednisolone given in 'pulses.' Possible mechanisms of clinical improvement are discussed.

Adult↗
PubMed1980

Effect of a rheumatology elective on house officers' evaluation of rheumatoid arthritis.

To ascertain whether a rheumatology elective (RE) increase the ability of house officers (HOs) to treat patients with rheumatic disease, 109 encounters involving patients with rheumatoid arthritis were audited. This permitted a comparison of 12 HOs who had had an RE with 55 HOs who had not. Results suggested that the RE led to better reporting of history and physical findings and increased the frequency with which relevant laboratory studies were ordered. During the 30-month period of the study, no increase was apparent in audit scores of HOs who had not had the elective, nor was any deterioration noted in scores of HOs who had participated in the elective with increasing length of the interval between the RE and the subsequent encounters.

Arthritis, Rheumatoid↗
PubMed1979

Systemic lupus erythematosus: association with psoralen--ultraviolet-A treatment of psoriasis.

Systemic lupus erythematosus (SLE) developed in as 23-year-old woman with psoriasis during treatment with psoralen-ultraviolet-A (PUVA). The connective tissue disease was characterized by an erythematous rash, hair loss, nephritis, splenomegaly, seizures, and coma. Serum antinuclear antibodies were present in high titer, and hypocomplementemia developed. Antibodies to native or ultraviolet-irradiated DNA were not demonstrated. While the association of psoriasis and lupus may have been fortuitous, the temporal relationships suggest that PUVA treatment in this case may have been of pathogenetic importance in the development of the connective tissue disease.

Adult↗
PubMed1979

Popliteal cyst mimicking thrombophlebitis as the first indication of knee disease.

Five patients, none of whom were previously known to have knee disease, developed leg swelling which was misdiagnosed as thrombophlebitis. Four were treated with anticoagulants and one developed a large calf hematoma requiring fasciotomy. The primary physicians failed to appreciate evidence of knee disease in these patients, although the rheumatology consultant found knee effusion, and a popliteal cyst was found by arthrography or ultrasonography in every case. The occurrence of popliteal cyst as the first sign of knee disease emphasizes the importance of careful examination of the knee in all patients with a clinical picture of thrombophlebitis.

Adult↗
PubMedDate not supplied

Some effects on house officers of an elective rheumatology rotation.

To ascertain whether a rheumatology elective (RE) increases the skills of house officers (HOs) managing patients with rheumatic disease, and whether these skills persist after the RE, medical records of 164 gouty patients, seen by 16 HOs who had had an RE and 73 who had not, were audited. The RE led to more complete documentation of history and physical examination and possibly to more frequent use of diagnostic arthrocentesis. Over the 30-month period of the study, no increase in scores of HOs not having a RE was apparent, while some deterioration, related to the interval between the RE and audit, was seen in scores of those who had an RE.

Arthritis, Rheumatoid↗