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S F Berndt

Publications and source records attributed to S F Berndt.

7 recordsLinked to original sources
PubMed1978

[Botulism].

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Adolescent↗
PubMed1976

Influence of papaverine derivatives on phosphodiesterase activity, cyclic 3',5'-AMP levels and relaxing effect on rabbit ileum.

The correlations between the relaxing effect of papaverine derivatives, inhibition of low Km-phosphodiesterase (cAMP-PDE = EC 3.1.4.17) activity and cyclic 3',5'-AMP (cAMP) levels in isolated rabbit ileum were investigated. There was a strong correlation between the relaxing effect, inhibition of PDE activity and cAMP content for eupaverine, ethylpapaverine and papaverine. Eupaverine was the most effective relaxing agent (I50 = 7.5 muM) and the most potent inhibitor of PDE activity (Ki = 0.6 muM), followed by ethylpapaverine (I50 = 10 muM;Ki 0.8 muM) and papaverine (I50 = 20 muM;Ki = 2 muM). In contrast, there was a strong relaxing effect (I50 = 6 muM) but only slight inhibition of PDE activity (Ki = 350 muM) by tetrahydropapaveroline (THP). The adenylate cyclase stimulating effect of THP which was shown by others is most likely the reason for comparatively higher cAMP levels, which were found to be elevated about seven times over basal levels of 0.35 nmoles/g wet weight, and effective relaxation. Relaxation could be induced by exogenously added cAMP (I50 = 45 muM) and dibutyryl-cAMP (I50 = 450 muM). Our results support the assumption that smooth muscle relaxation in rabbit ileum is mediated by cAMP. Some of these observations have been published in abstract form (Schulz and Berndt, 1972).

3',5'-Cyclic-AMP Phosphodiesterases↗
PubMed1976

[Continuous EEG monitoring and clinical chemical findings in poisoning from Death cap (Amanita phalloides) (author's transl)].

The changes in the EEG were put in relation to the clinical course and liver function tests in 3 cases of acute poisoning by Amanita phalloides. Within discrete disturbances of liver function, distinct paroxysmal changes and increased interspersion of epsilon waves in the EEG are already found on the second day after taking the fungi. The liver dystrophy developing in the later course, recognisable by Quick values below 2%, at first only produces a small increase in the EEG changes. On the 5th or 6th day, severe general changes in the EEG appear along with symptoms of confusion to delirium. At this time, no further deterioration of the laboratory findings were demonstrable, but on the contrary we already even found a distinct improvement in the liver function. With further continuous increase in the clotting factors, the EEG becomes increasing slower in the next 4 days and after surviving this stage, improves very quickly thereafter. Our findings show that in poisoning with Amanita phalloides, EEG changes may become manifest even before the appearance of psycho-pathological changes and do not correlate directly with the tangible technical liver function tests of the laboratory.

Adult↗