Maternal to fetal movement of creatinine as a measure of perfusion efficiency and diffusional transfer in the isolated human placental lobule.
A method employing the maternal to fetal transfer of the slowly diffusing molecule creatinine in the closed-circuit dual perfusion of a term human placental lobule is described. This molecule provides an alternative to the use of antipyrine and is a useful tool in determining the overlap of the two circulations and the available exchange area in this preparation.
Antipyrine↗