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Biomedical subjects

S F Grebe

Publications and source records attributed to S F Grebe.

12 recordsLinked to original sources
PubMed1989

[The use of modern scintigraphic methods for the control of thyroid gland function in small laboratory animals].

In the present investigation modern scintigraphic methods like scanner- and gamma camera-techniques have been used for the first time to diagnose the thyroid function of small laboratory animals. Both methods have been tested on completely or partially iodine-resected rats. Because the results concerning the gamma camera could be quantified they could be compared to those of the gamma counter as a reference method. Assuming a linear relationship between both methods a correlation coefficient of r = 0.97 (n = 32) could be calculated. The capacity of both the scanner and the gamma camera was high enough to show even small amounts of residual thyroid tissue. Therefore both methods are extremely suitable for the diagnosis of the thyroid function. Using them as a control of the iodine-resection of the thyroidea a control group of animals is not necessary and, therefore, less animals are required. With regard to the narcosis of heavily hypothyroid animals it must be noted that the usually pentobarbital dosage must at least be reduced by one third.

Animals↗
PubMed1978

The use of gallium-67 in pulmonary disorders.

Imaging of the chest cage with gallium-67 (67Ga) citrate is relatively easier to perform and interpret than imaging of the abdomen, because normally pulmonary concentration is low after 48 hr and physiologic accumulation in bones and breast can be recognized by its distribution. Modern scintillation detectors, particularly large field cameras with multiple pulse-height analyzers, give substantially better gallium images than those available in the past. Because of the nonspecific affinity of gallium through neoplastic and inflammatory processes, its value in the differential diagnosis of pulmonary diseases is limited. However, based on the literature and our own observations in over 1100 patients with established diagnosis of a variety of pulmonary diseases, we feel that the judicious use of 67Ga in selected patients is helpful in answering specific questions. These include preoperative evaluation of hilar and mediastinal involvement in pulmonary neoplasms, differential diagnosis of pulmonary infarctions and bacterial pneumonias, evaluation of pulmonary infiltrates regarding infectious etiology, follow-up of sarcoidosis on corticosteroid treatment, assessment of inflammatory activity in interstitial fibrosis and, in selected cases, early detection of neoplastic and inflammatory diseases before radiography becomes abnormal, such as diffuse carcinomatosis and Pneumocystis carinii infection. Potential large-scale application of pulmonary gallium imaging could be found in the screening of subjects exposed occupationally to noxious dust and in long-term serial follow-up of pulmonary tuberculosis patients for treatment response and reactivation. However, it remains to be seen whether gallium imaging statistically provides essential additional information in these indications when compared to cheaper conventional techniques.

Diagnosis, Differential↗
PubMed1978

[Results of quantitative radionucleid investigations in acute testicular disease (author's transl)].

All publications dealing with tortion of the testis stress the difficulty of diagnosis and the frequency of errors. This has suggested to us the need to develop a radio-isotope testiculogram corresponding to the radioisotope nephrogram used for renal functional diagnosis. The substance for the timeactivity curve is 99mTc pertechnitate which is taken up by the tubular epithelium of the testis and epididymis. A scan at 20 minutes proved highly diagnostic and produced a small amount of radiation only. Six quantitative parameters described the shape of the curve. These have been determined for the normal and related to age and point of measurement. It is then possible to differentiate partial and total tortion from acute epididymoorchitis. It is no longer necessary to subject every patient with acute testicular disease to surgery. With partial tortion, a conservative operation with fixation of the testis can be recommended instead of semicastration.

Acute Disease↗
PubMed1976

Gallium-67 scintigraphy of pulmonary diseases as a complement to radiography.

Gallium chest scans of 575 patients were analyzed for their clinical usefulness in conjunction with chest radiographs. The series included patients with pulmonary carcinoma, lymphoma, tuberculosis, sarcoidosis, pneumoconiosis, and interstitial fibrosis. Gallum scintigraphy does not aid in the differential diagnosis of pulmonary diseases but is helpful in determining (a) the degree of activity of a known disease process: (b) treatment response, dosage, and duration; (c) the spatial extent of the disease; and (d) the presence of unsuspected disease foci hidden radiographically in the mediastinum, behind the heart, or in pleural or parenchymal scars.

Gallium Radioisotopes↗
PubMed1976

[User-oriented programs for semi-automated evaluation of radio in vitro tests].

Most of the programmes for the evaluation of radio in vitro tests proceed from the anticipation that the best method should give an approximation of standard values by a curve as perfect as possible. According to our experiences this demand, however, is not decisive for a good standard curve, as in principle all standard values can be incorrect. The application of relatively simple linearising transformations and an additional curve (recovery of a normal serum) guarantees the necessary precision in the programme described. After a short description of the contents of the system, the programme for the assessment of CPBA - methods is shown, by help of which the sample changer - calculator-system determines the absolute concentration of the substance to be measured. This makes the starting point for the more complex RIA programme which methodologically takes into consideration the special problems of these tests.

Diagnosis, Computer-Assisted↗
PubMed1975

[Scintigraphy. 2].

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Bone Diseases↗
PubMed1975

[Scintigraphy. 1].

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Biological Transport↗