[Experience with using washed, thawed erythrocytes in operations with artificial circulation].
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Biomedical subjects
Publications and source records attributed to S F Leonova.
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Acid-base balance and lactate concentration in the arterial blood and spinal liquor have been studied in 32 patients after air embolism of the brain vessels developed during cardiopulmonary bypass surgery. It has been shown that an increase of lactate concentration in the spinal liquor over 3.5 mmol/l after air embolism of the brain vessels is indicative of severe hypoxic brain damage, in which the prospect of stable consciousness recovery is doubtful. In lactate concentration 4.5-5 mmol/l and higher as well as in metabolic acidosis of liquor (sodium hydrocarbonate concentration less than 20 mmol/l) the intensive care procedures used were not effective. It is believed that these parameters are of prognostic value in the condition under study.
Doppler echographic criteria were developed to define the anaerobic threshold and to detect lower extremity ischemia. Multi-stage treadmill test provided the criteria involving impairments in the time course of recovery of continuous diastolic blood flow in the lower extremity arteries. The criteria allow the anaerobic threshold to be defined in the range of low and high exercises and the severity of ischemia of the saved and amputated limb to be assessed in arterial occlusions. The diagnostic sensitivity of the criteria is 82-87%, its specificity and predictive value are 95-100%.
The program is based on measuring the parameters determining the relationships between oxygen, blood acid-base, and blood and urine water-electrolyte balance in 150 patients after cardiopulmonary bypass surgery. Three degrees of homeostasis were distinguished: normal, hypoxic complications, and fatal hypoxic complications. The most informative laboratory tests reflecting the oxygen status and acid-base and water-electrolyte balance and indicating the presence and severity of hypoxic complications of homeostasis were selected. Graphic presentation of the probability scale predicting the hypoxic disorders helps more rapidly (than with the digital values) assess the severity of oxygen homeostasis disorders in patients. The PROGNOZ computer program may be used for the diagnosis and prediction of hypoxic disorders in intensive care units for cardiological and cardiosurgical patients.