Biomedical subjects
Publications and source records attributed to S F Serov.
Electron-microscopy examination of 13 soft tissue tumors in human subjects has revealed in four of them, diagnosed histologically as polymorphous-cellular sarcoma, fibrosarcoma, monophase and biphase synovioma, the ultrastructural features allowing them to be classified as rhabdomyosarcomas.
The study is based on the authors' personal material (81 patients). It was found that malignant endometrioid ovarian tumors invade metastatically the greater omentum more rarely than serous carcinomas--in 42% according to our findings, versus 60--80% as reported in the literature with regard to serous neoplasms. Metastases of endometrioid carcinoma into the omentum are more frequently observed in patients over 40. Ascitic fluid is found in 38% of the patients, that is twice as rare as in serous cystic adenocarcinomas.
Using electron microscopy the authors have studied the operation material of 15 patients with serous (9 cases) and endometrioid (6 cases) ovarian neoplasms. It was demonstrated that the epithelium of endometrioid neoplasms differs from that of serous ones by less polymorphism, the absence of cilia, the signs of secretory activity and more intense development of tonofibrils in the cytoplasm.
Use of the complex of morphological methods (histological, morphometric, electron microscopy and tissue culture technic) in examining the operation material enabled a more precise and full idea to be formulated of the principal stages of the morphogenesis of serous ovarian cystomas and also allowed the validation of their differentiation between benign, boundary (intermediate) and malignant types.
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Based on histomorphological study of over 200 observations, the author suggests the morphological characteristics of basic varieties of secondary ovarian tumors. Some aspects of the nomenclature are discussed, and the classification of neoplasms under consideration is presented. Among epithelial secondary tumors of the ovaries special attention is given to Krukenberg tumor and metastases of cancer with "functioning stroma". The classification also takes into account mesenchymal, neurogenic, hemopoietic and other tumors.
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