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Biomedical subjects

S F Witelson

Publications and source records attributed to S F Witelson.

24 records · Page 2Linked to original sources

Developmental dyslexia: two right hemispheres and none left.

Developmental dyslexia may be associated with (i) bi-hemisphere representation of spatial functions, in contrast to the right-hemisphere specialization observed in normal children, and (ii) typical left-hemisphere representation of linguistic functions, as is observed in normal children. The bilateral neural involvement in spatial processing may interfere with the left hemisphere's processing of its own specialized functions and result in deficient linguistic, sequential cognitive processing and in overuse of the spatial, holistic cognitive mode. This pattern of cognitive deficits and biases may lead dyslexics to read predominantly with a spatial-holistic cognitive strategy and neglect the phonetic-sequential strategy. Such an approach in learning to read phonetically coded languages, such as English, many be inefficient and limited.

Adolescent↗

A computer-assisted direct-imaging system to obtain numerical densities of neurons in human cortex.

Studies of the numerical density of microscopic items in brain tissue is a time-consuming endeavor. However, such information is important for numerous issues such as the relationship between structure and function in the normal brain, individual differences, and studies of brains of neuropsychiatric patients. A computer-assisted imaging system specifically devised to obtain estimates of numerical densities in human cortex is described here. Its main advantage is that the microscopist can analyze the original image directly under the microscope, and most aspects of data acquisition and quantitative analysis are accomplished by the computer. The key features of the system are a Microvid (an electronic camera lucida) and the use of X, Y, and Z stage encoders in conjunction with three-dimensional computer software. The complete system is relatively inexpensive and is simple to set up and use. The reliability and validity of the numerical densities obtained using this system are documented.

Cell Differentiation↗