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Biomedical subjects

S F Worrall

Publications and source records attributed to S F Worrall.

At least 19 recordsLinked to original sources
PubMed2001

An audit of general dental practitioners' referral practice following the distribution of third molar guidelines.

Oral and maxillofacial surgery waiting lists are amongst the longest of any surgical specialty. The majority of patients on these waiting lists have been referred for removal of their third molars (wisdom teeth). With increasing pressure to reduce the size of both out-patient and surgical waiting lists, it is important to ensure that only those patients with a recognised clinical need are referred and accepted for treatment. In April 1998, local general dental practitioners were issued guidelines for the management of patients with impacted third molars. This paper describes an audit that assessed the impact of this intervention. The results suggest that referral guidelines are an effective means of changing general dental practitioners' referral practice and that, used along with other strategies, could be effective in reducing oral and maxillofacial surgery out-patient and surgical waiting lists.

Communication↗
PubMed1999

Cyclin D1, glutathione S-transferase, and cytochrome P450 genotypes and outcome in patients with upper aerodigestive tract cancers: assessment of the importance of individual genes using multivariate analysis.

GST, CYP, and CCND1 genotypes have been associated with outcome in several cancers. Accordingly, we have examined, in patients with one squamous cell carcinoma (SCC) of the head and neck, associations between GSTM1, GSTT1, GSTM3, GSTP1, CYP2D6, CYP1A1, CYP2E1, and CCND1 genotypes and the outcome parameters, tumor extension, histological grade, and presence of nodes. We used logistic regression to study, first, each gene individually and, second, in a step-wise model that included all of the genes. Different genes were associated with each outcome parameter. Thus, GSTT1 null was associated with T3/T4 lesions in the oral cavity/pharyngeal (P = 0.029), but not laryngeal, SCC cases. GSTT1 null was also associated with histological differentiation (G3) in the oral cavity/pharyngeal, but not laryngeal, SCC cases, although this association only approached significance (P = 0.069). CCND1 GG was associated with G3 tumors in the oral cavity/pharyngeal (P = 0.011), but not laryngeal, SCC cases. The combination of GSTT1 null/CCND1 GG was also associated with G3 tumors. CYP2D6 PM and HET were associated with lymph node involvement in the laryngeal, but not oral/pharynx, SCC cases. Genes that were individually associated with outcome were also associated with the parameter in the step-wise routine. The GSTT1 null frequency was greater in 39 patients with second primary tumors than in those with one lesion (P = 0.014). The data demonstrate site-dependent associations between GSTT1 null, CCND1 GG, and CYP2D6 PM and tumor extension, differentiation, and nodes.

Carcinoma, Squamous Cell↗
PubMed1998

UK National Third Molar project: the initial report.

The National Third Molar (NTM) project was set up to assess current clinical practice in the UK concerning the management of third molar teeth. Patients were recruited from both hospital and general dental practice. During the one month study period 9248 patients with 26,577 third molars were recruited. In this report we present the findings in the 8298 patients with 25,001 third molars who were referred to hospital for assessment. Over half of all patients referred for assessment had either no extractions or a single third molar extracted. Less than a quarter of all patients referred underwent removal of all four third molars. Twenty per cent of all third molars assessed were not extracted. Of all lower third molars listed for extraction, 9574 (78%) were associated with symptoms or disease. Pericoronitis was the commonest indication for extraction and was cited in 39.5% of all extractions. Almost 70% of third molar extractions were done under general anaesthesia while less than a quarter were performed under local anaesthesia alone.

Adult↗
PubMed1998

The glutathione S-transferase GSTP1 polymorphism: effects on susceptibility to oral/pharyngeal and laryngeal carcinomas.

We have examined the hypothesis that the polymorphic, glutathione S-transferase GSTP1 gene is a susceptibility candidate for squamous cell cancer of the oral/pharynx and larynx. We describe GSTP1 genotype frequencies in 380 cases and 180 controls. We found a lower frequency of GSTP1 AA in the oral/pharyngeal cases compared with controls (p = 0.003, odds ratio = 0.47) after correction for age and gender. We used an immunohistochemical approach to show widespread expression of the GSTP1 subunit throughout the pharynx and larynx. In uninfiltrated tissue, strong positivity was found throughout the squamous cell epithelium with the exception of the basal cell layer. The cilia of the respiratory epithelium of the larynx also showed positivity for GSTP1. In tumour tissue, expression of GSTP1 was similar in pharyngeal and laryngeal samples. These data are the first to show that polymorphism at GSTP1 mediates susceptibility to squamous cell cancer of the upper aerodigestive tract. No significant interactions were identified between GSTP1 and GSTM1, GSTM3, GSTT1 and the cytochrome P450 CYP1A1, CYP2D6 and CYP1A1 genotypes.

Alcohol Drinking↗
PubMed1998

Susceptibility and outcome in oral cancer: preliminary data showing an association with polymorphism in cytochrome P450 CYP2D6.

Members of the cytochrome P450 and glutathione S-transferase supergene families are candidates for susceptibility and outcome in oral squamous cell cancer. We determined GSTM1, GSTM3, GSTT1, CYP1A1 and CYP2D6 genotypes in 100 Caucasian cases and 467 control individuals. The frequency of homozygosity for mutant CYP2D6 alleles was higher in the cases (P = 0.001, OR = 3.2, 95% CI = 1.6-6.5) than control individuals. In the cases, the frequency of homozygosity for mutant alleles was greater and that of homozygosity for wild-type CYP2D6 alleles was lower in those diagnosed at > or = 65 years (P = 0.009) than in those diagnosed at < or = 64 years. The older cases included relatively more women and patients who did not consume tobacco or alcohol. The association of CYP2D6 with outcome was assessed using the Cox's proportional hazards model. The time to first cervical node metastasis was shorter in heterozygotes and homozygotes for mutant CYP2D6 alleles compared with homozygotes for wild-type alleles after correction for age at diagnosis, gender, alcohol and tobacco consumption and tumour differentiation (P = 0.04, hazard ratio 3.6, 95% CI 1.1-12.5). The mechanism for the association of CYP2D6 alleles with susceptibility and outcome is unclear though the data are compatible with the view that homozygosity for mutant alleles confers impaired detoxication of an unknown carcinogen. No associations between GSTM1, GSTM3, GSTT1 or CYP1A1 genotypes and susceptibility or, time to node metastases were identified. We previously showed that CYP2D6 genotypes were not associated with susceptibility to squamous cell cancer in the pharynx or larynx. Therefore, the data presented suggest that susceptibility to squamous cell cancer in the various parts of the upper aerodigestive tract is associated with different genes and allelic variants.

Adult↗
PubMed1998

Polymorphism in cytochrome P450 CYP2D6, CYP1A1, CYP2E1 and glutathione S-transferase, GSTM1, GSTM3, GSTT1 and susceptibility to tobacco-related cancers: studies in upper aerodigestive tract cancers.

Glutathione S-transferase GSTM1, GSTM3 and GSTT1 and cytochrome P450 CYP2D6, CYP1A1 and CYP2E1 loci are susceptibility candidates for cancers of the upper aerodigestive tract because putatively protective and risk genotypes have been identified from studies in other diseases associated with alcohol and tobacco consumption. We describe genotype frequencies in 398 oral, pharyngeal and laryngeal squamous cell carcinoma patients and 219 control individuals. Of the genotypes presumed to be protective, only GSTM1 A/B influenced susceptibility; the GSTM1 A/B frequency was lower in the patients than the control individuals both before [odds ratio = 0.3, 95% confidence interval (CI) 0.1-0.7] and after correction for imbalances in age, sex, smoking and alcohol consumption (odds ratio = 0.2, 95% CI 0.1-0.5). Of the putatively risk genotypes, GSTM3 AA, previously associated with susceptibility to skin cancer, was higher in the cases (odds ratio = 1.6, 95% CI 1.1-2.4). Dividing cases into oral/pharyngeal and laryngeal squamous cell carcinoma showed the GSTM3 AA frequency was higher in laryngeal squamous cell carcinoma than control individuals (odds ratio = 1.6, 95% CI 1.1-2.5) and the difference between control individuals and oral/pharyngeal squamous cell carcinoma approached significance (odds ratio = 1.7, 95% CI 1.0-2.8). The putatively protective GSTM3 BB genotype was lower in patients with glottic (1.0%) than supraglottic (3.0%) squamous cell carcinoma. We identified no differences between patients and control individuals in the frequencies of presumed risk genotypes (e.g. CYP2D6 EM, CYP1A1 m1/m1, CYP1A1 Ile/Ile, CYP2E1 DD, CYP2E1 c1c1, GSTT1 null) or, interactions between genotypes and smoking or alcohol consumption. We conclude, first, that mu class glutathione S-transferase influence risk of upper aerodigestive tract cancers thereby complementing studies in skin cancer patients showing GSTM1 A/B is protective, while GSTM3 AA moderately increases risk. The influence of GSTM1 A/B, but not GSTM1 A or GSTM1 B (mostly heterozygotes with GSTM1*0) suggests that two expressed alleles may attenuate risk. While we found immunohistochemical evidence of GSTM3 expression in the cilia lining the larynx, the biochemical consequences of the polymorphism are unclear. Indeed, the influence of the gene may reflect linkage disequilibrium with another gene. However, we did not find an association with GSTM1 genotypes. Second, we conclude that the CYP2D6, CYP2E1, CYP1A1 and GSTT1 alleles studied, although putatively good candidates, either do not determine the effectiveness of detoxification of tobacco-derived carcinogens in the upper aerodigestive tract or, that chronic consumption of tobacco and alcohol overwhelms enzyme defences, irrespective of genotype.

Aged↗
PubMed1996

Are postoperative review appointments necessary following uncomplicated minor oral surgery?

This paper reports the results of a postal survey of all current BAOMS Fellows concerning their practice and opinion on the usefulness and desirability of reviewing all patients following uncomplicated minor oral surgery. It also reports the results of a separate postal survey of 500 patients who had recently undergone third molar removal. The overwhelming majority of Fellows routinely review all their patients following third molar removal and apicectomy but not after simple exodontia. There was no excess morbidity in patients who were not offered a follow-up appointment compared to those who had been seen postoperatively after removal of their third molars. Patients not followed up in hospital postoperatively did not seek help from their doctor or dentist more frequently than patients who were followed-up. Despite the lack of evidence showing objective benefit to patients from postoperative follow-up, given the choice the majority of patients wish to be reviewed postoperatively.

Anesthesia, Dental↗
PubMed1995

An audit of one surgeon's experience of oral squamous cell carcinoma using computerised malignancy database.

The results of an audit of a single surgeon's experience of oral squamous cell carcinoma over a 5-year period is reported and the benefits of adopting a prospective computerized malignancy database outlined. Oral cancer occurred mainly in the 7th decade of life, women were on average 5 years younger than men at presentation. Men were affected 1.7 times as often as women and presented with more advanced disease than women. The mean delay from referral to histological diagnosis was 6.4 days and the mean delay from diagnosis to treatment was 25.8 days. The majority of patients consumed alcohol and smoked tobacco, but a significant minority were lifelong nondrinkers and non-smokers. While the incidence of most site-specific oral cancers were similar to the national averages the incidences of alveolar and floor of mouth cancers were higher than expected. The TNM stage at presentation was an unreliable prognostic indicator of future disease progression and outcome. Auditing treatment and outcome is a major component of the recent proposals to centralise the provision of cancer services in dedicated cancer centres and units (1). Audit can only be effective if it is based on current, reliable and accurate data and this can only be achieved by the use of a computerised malignancy database.

Adult↗
PubMed1994

Changes in weight and body composition after orthognathic surgery and jaw fractures: a comparison of miniplates and intermaxillary fixation.

OBJECTIVES: To compare the changes in postoperative weight and body composition following orthognathic surgery or jaw fractures treated by intermaxillary fixation (IMF) or miniplate osteosynthesis. DESIGN: A 4-month non-randomised prospective pilot study. Body composition was assessed using the 4 site skinfold thickness technique. The fixation method used in each case was dependent on clinical criteria alone. SETTING: Oral and maxillofacial surgery units at St James's University Hospital and the General Infirmary at Leeds. SUBJECTS: All patients were eligible for inclusion in the study if they had sustained a jaw fracture or had undergone orthognathic surgery. Patients were excluded if they had sustained polytrauma, if their sole orthognathic surgery procedure was a genioplasty and if the author was not directly involved in their management. The final study group consisted of 22 patients, 18 following surgical correction of jaw fractures and 4 following elective orthognathic surgery. Thirteen patients were managed with intermaxillary fixation and 9 patients were treated with miniplate osteosynthesis. MAIN OUTCOME MEASURES: Weight, lean body mass, total body water, fat and water free lean body mass, 1 week and 6 weeks postoperatively. RESULTS: There was no significant difference in weight loss or body composition changes between the plated and non plated groups at 1 week postoperatively. However, by 6 weeks postoperatively the IMF group had lost significantly more weight (4.5 kg) than the plated group (1.1 kg). In the plated group this weight loss resulted entirely from a loss of lean body mass (77% water), whereas in the other group it resulted from a fat loss of 1.2 kg plus a lean body mass loss of 3.3 kg (73% water). Estimated protein losses were 0.9 kg for the IMF group and 0.3 kg for the plated group. CONCLUSIONS: Intermaxillary fixation compromises nutritional status in the early postoperative period leading to loss of water, fat and protein. The results of this pilot study suggest that further investigation of postoperative weight and body composition changes after oral and maxillofacial operations is indicated.

Adipose Tissue↗
PubMed1994

Closure of large orocutaneous fistulas in end-stage malignant disease.

Expanding Silastic foam was used to close and dress a large orocutaneous salivary fistula secondary to a massive local recurrence of squamous cell carcinoma. The technique is simple, rapid, and effective. The patient found the dressing superior in every way to the traditional absorbent dressings previously supplied. We recommend this technique for the closure of large defects in the head and neck.

Bandages↗
PubMed1992

Recurrent odontogenic keratocyst within the temporalis muscle.

Recurrence following treatment of odontogenic keratocysts is not infrequent. However, recurrence within soft tissues is rarely reported. A case of an odontogenic keratocyst recurring within the temporalis muscle is described with a brief review of the literature concerning cyst recurrence.

Humans↗
PubMed1991

Mechanisms, pattern and treatment costs of maxillofacial injuries.

Facial contact with the steering wheel was the most common source of maxillofacial injuries sustained by vehicle occupants. Maxillofacial injuries to non-restrained occupants, especially children, most commonly resulted from contact with the vehicle's seats. In contrast to previous studies, contact with the windscreen by non-restrained occupants produced only a small number of minor facial injuries. Serious fractures of the facial skeleton were rare and no maxillofacial injury was fatal. A relationship between impact speed and the severity of facial injury sustained was demonstrable. Total compliance with seat belt legislation could be expected to save the National Health Service in excess of 5 pounds million/year from the reduction in maxillofacial injuries alone.

Accidents, Traffic↗