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S Falsini

Publications and source records attributed to S Falsini.

3 recordsLinked to original sources
PubMed1991

Exogenous glutathione increases endurance to muscle effort in mice.

Many data suggest an involvement of toxic oxygen radicals in the termination of endurance to muscle fatigue. Being reduced glutathione (GSH), an efficient intracellular physiological antioxidant, experiments have been performed to discover whether exogenous GSH modifies endurance to exhaustive swimming in mice. GSH was administered to mice as a single dose (250, 500, 750 or 1000 mg/kg i.p.) or as repeated doses (250 mg/kg i.p. once a day during 7 days) 10 min before a swimming test to exhaustion. GSH 500, 750 and 1000 mg/kg, increased endurance to swimming by respectively 102.4%, 120.0% and 140.7%. GSH 250 mg/kg did not affect endurance when injected in a single dose but increased it by 103.7% when injected once a day for 7 days.

Animals↗
PubMed1990

Spin-trappers and vitamin E prolong endurance to muscle fatigue in mice.

The involvement of free radicals in endurance to muscle effort is suggested by experimental and clinical data. Therefore, experiments have been performed to observe the effect of trapping free radicals on endurance to swimming in mice. Animals were injected intraperitoneally with each of three spin-trappers [N-tert-Butyl-alpha-Phenyl-Nitrone (PBN),alpha-4-Pyridyil-1-Oxide-N-tert-Butyl-Nitrone (POBN) and 5,5-Dimethyl-1-Pirrolyn-N-Oxide (DMPO): 0.2 ml of 10(-1) molar solution]. Each mouse was submitted to a swimming test to control resistance to exhaustion a) without any treatment, b) after administration of each spin-trapper in a random order c) after saline. Control experiments were performed with saline and with vitamin E. Endurance to swimming was greatly prolonged by pretreatment with all the spin-trappers (DMPO less than 0.0001; POBN less than 0.0001; PBN less than 0.001) and with Vitamin E. Experiments state that compared to treatment with spin-trappers or Vitamin E, administration of saline alone did not enhance time to exhaustion so that the increase in time to exhaustion with the various free radical scavengers was not the effect of training. Therefore, free radicals could be considered as one of the factors terminating muscle effort in mice.

Animals↗