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S Farkas

Publications and source records attributed to S Farkas.

66 records · Page 4Linked to original sources
PubMed1978

Study of pancreatic tissue pH in the early stage of experimental acute pancreatitis.

Pancreatic pH was measured electrometrically over a period of 3 h in 34 dogs with acute necrotic pancreatis. The disease had been induced with sunflower oil in 10, with Na-taurocholate in 10 and with hen's egg yolk in 10 animals. Four dogs served as controls. The pH of the pancreatic tissue changed differently in the different groups, in accordance with the different pathomechanisms. Injection of sunflower oil was followed by a protracted acidosis of pancreatic tissue, that of taurocholate by a transitory moderate decline of pH. Egg-yolk produced an evanescent, slight fall in pancreatic pH, followed by complete normalization within a few minutes. The differences between the initial and the 3-h values attain the level of significance only in case of sunflower-oil pancreatitis.

Acute Disease↗
PubMedDate not supplied

Conditioning of liver grafts with prostaglandins improves bile acid transport.

INTRODUCTION: Conditioning of liver grafts by bolus pretreatment with prostaglandins has been previously demonstrated to improve hepatic bile flow. However, the underlying mechanisms have not been investigated. To elucidate whether improved bile flow after prolonged ischemia is due to maintained bile acid secretion or due to increased paracellular permeability, we performed a study using increasing doses of the marker acid taurocholate in the isolated perfused rat liver system. METHODS: Livers were harvested from adult Lewis rats and stored for 24 hours in UW solution. Pretreatment of livers was performed 1 minute before preservation. One group received prostaglandin I2, the second group received prostaglandin E1, and the control group was treated with saline. After 24 hours of cold storage the grafts were investigated in the isolated perfused rat liver system by perfusion with an oxygenated Krebs-Ringer-Henseleit buffer. Increasing doses of the radiolabeled marker bile acid taurocholate were infused to investigate bile acid transport. RESULTS: Bile flow and bile acid output were increased by pretreatment of the livers with prostaglandin I2 and prostaglandin E1, as compared to the control group. More specifically, the maximum transport rate was tripled by prostaglandin I2 and by prostaglandin E1 preconditioning of liver grafts, in comparison to the control group (P < .01 vs prostaglanin I2 and E1). CONCLUSION: The results clearly demonstrate that increased bile flow after conditioning of liver grafts with prostaglandins is not due to increased paracellular permeability but is based on markedly improved bile acid output.

Adenosine↗
PubMedDate not supplied

Enhanced antibacterial effect of erythromycin in the presence of 3,5-dibenzoyl-1,4-dihydropyridines.

Fifteen 3,5-dibenzoyl-1,4-dihydropyridines (BzDHP, GB1-GB15) (nifedipine (NP) analogs) were tested on three different E. coli strains. The compounds had relatively high MIC values on these strains. In combination with erythromycin (Er), compounds (G1,3,4,6,7,10,12) reduced MIC values of Er. When the BzDHPs were tested on E. coli Gy-1/Apsen.Erres strain isolated from a clinical specimen, the reduction of MIC values were similar to the previous strains, but not identical. In the polyresistant clinically isolated E. coli Gy-2/Apres.Erres strain, the MIC values of Er were slightly reduced in the presence of GB1-GB7. Compound GB12 was the most effective in enhancing the activity of Er, and was selected for plasmid elimination studies. However, GB12 itself had no antiplasmid effect and did not alter the promethazine induced plasmid elimination.

Anti-Bacterial Agents↗