Biomedical subjects
Publications and source records attributed to S Farooqi.
In this review we discuss the physiological effects of somatostatin, which are mediated by specific receptor subtypes on different tissues. These observations have suggested new therapeutic possibilities for the use of the synthetic somatostatin analogues in the treatment of acromegaly as well as a number of other endocrine and non-endocrine disorders.
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Certain infant care practices have consistently been shown to play an important role in the aetiology of the sudden infant death syndrome (SIDS). In the UK, the incidence of SIDS amongst Asians is less than half that of whites. We conducted a questionnaire-based survey of 374 multiparous mothers from a multiracial community in Birmingham. We found that the majority of Asian infants slept in the parental bedroom at night, 94% compared to 61% of whites, whilst 33% of white infants slept alone compared to 4% of Asians. Three times as many white mothers as Asians placed infants prone (31% vs. 11%). We, therefore, observed marked differences in the infant care practices of Asians compared to whites in the UK, which may partly account for the low incidence of SIDS amongst infants of Asian origin.
A high cardiovascular mortality rate exists amongst people of Indo-origin in Trinidad (third generation migrants) and the United Kingdom (first generation migrants). To investigate the differences in cardiovascular risk factors in these two populations, we surveyed all male patients of Indo-origin with acute myocardial infarction, admitted over a similar 8-week period to the Coronary Care Units of a district general hospital in Birmingham, United Kingdom and a similar hospital in San Fernando, Trinidad. Nineteen patients (mean age 62.2 years +/- S.D. 2.58) were admitted to the Birmingham hospital (UK Group) and fifty-five (mean age 58.1 years +/- S.D. 1.44) to the San Fernando hospital (Trinidad Group). There was no age difference between the groups (P = 0.18). There was a significantly greater proportion of smokers in the Trinidad group (70.9% vs. 63.2%, chi 2 = 4.56, P = 0.03), which also had a higher proportion of diabetics (36.4% vs. 31.6%) and hypertensives (34.5% vs. 31.6%). Mean systolic and diastolic blood pressures were higher in hypertensives from the Trinidad group (Trinidad group 146.6 mmHg +/- 16.9/93.4 mmHg +/- 11.4 vs. UK group 120.8 mmHg +/- 25.4/75.0 mmHg +/- 13.4; P < 0.05). The mean waist to hip ratio was greater in the Trinidad group (1.01 +/- S.D. 0.06) when compared to the UK group (0.95 +/- S.D. 0.05) (paired t-test, P < 0.01). Only six Trinidadian males performed regular exercise and only four of the UK group did so.(ABSTRACT TRUNCATED AT 250 WORDS)
The aetiology of sudden infant death syndrome (SIDS) is still uncertain, although associations with overheating and the prone sleeping position have been reported. In the UK, the incidence of SIDS is considerably lower in infants of Asian origin, but as yet no explanation for this has been suggested. We have studied a group of 202 white and 172 Asian multiparous mothers attending an antenatal clinic to compare the sleeping position and home environment of infants in each ethnic group. We found that significantly more white infants (31%) than Asians (11%) were placed in the prone position at night and that 94% of Asian infants slept in their parents' bedroom, compared with 61% of whites. These observations demonstrate marked differences in the infant rearing practices favoured by Asians and whites and lend support to the concept that the prone position and separate bedrooms may be contributors to the development of sudden infant death.
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The first reported case of a patient with left internal mammary artery bypass graft dissection secondary to selective coronary and graft arteriography is presented. The intimal tear and false lumen could not be seen with flouroscopy during catheterization. This later led to antero-septal myocardial infarction.
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